Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Rehana K. Leak"'
Autor:
Miao Wang, Connor Dufort, Zhihong Du, Ruyu Shi, Fei Xu, Zhentai Huang, Ana Rios Sigler, Rehana K. Leak, Xiaoming Hu
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Brain microglia and infiltrating monocyte-derived macrophages are vital in preserving blood vessel integrity after stroke. Understanding mechanisms that induce immune cells to adopt vascular-protective phenotypes may hasten the de
Externí odkaz:
https://doaj.org/article/7782ed0460bd40a5babf389623251faa
Autor:
Tarun N. Bhatia, Anuj S. Jamenis, Muslim Abbas, Rachel N. Clark, Kristin M. Miner, Manisha N. Chandwani, Roxanne E. Kim, William Hilinski, Lauren A. O'Donnell, Kelvin C. Luk, Yejie Shi, Xiaoming Hu, Jun Chen, Jeffrey L. Brodsky, Rehana K. Leak
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106196- (2023)
Reactive microglia are observed with aging and in Lewy body disorders, including within the olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia in these disorders is still debated. Resetting these reactive cell
Externí odkaz:
https://doaj.org/article/9721d7f26b7b4036901bb4feac886942
Autor:
Hongjian Pu, Yangfan Wang, Tuo Yang, Rehana K. Leak, R. Anne Stetler, Fang Yu, Wenting Zhang, Yejie Shi, Xiaoming Hu, Ke-jie Yin, T. Kevin Hitchens, C. Edward Dixon, Michael V.L. Bennett, Jun Chen
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106078- (2023)
Traumatic brain injury (TBI) is commonly followed by intractable psychiatric disorders and long-term changes in affect, such as anxiety. The present study sought to investigate the effect of repetitive intranasal delivery of interleukin-4 (IL-4) nano
Externí odkaz:
https://doaj.org/article/2cc010faead44f79a9f7f797f81fd883
Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice
Autor:
Wei Cai, Ligen Shi, Jingyan Zhao, Fei Xu, Connor Dufort, Qing Ye, Tuo Yang, Xuejiao Dai, Junxuan Lyu, Chenghao Jin, Hongjian Pu, Fang Yu, Sulaiman Hassan, Zeyu Sun, Wenting Zhang, T. Kevin Hitchens, Yejie Shi, Angus W. Thomson, Rehana K. Leak, Xiaoming Hu, Jun Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Immunomodulation holds therapeutic promise against brain injuries, but leveraging this approach requires a precise understanding of mechanisms. We report that CD8+CD122+CD49dlo T regulatory-like cells (CD8+ TRLs) are among the earliest lymphocytes to
Externí odkaz:
https://doaj.org/article/6faa48ac6514477ea85a1c9ae8ac6563
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Stroke remains a major cause of long-term disability and mortality worldwide. The immune system plays an important role in determining the condition of the brain following stroke. As the resident innate immune cells of the central nervous system, mic
Externí odkaz:
https://doaj.org/article/b3c125c35c2d4c40b2b47256c6a194ab
Autor:
Rehana K. Leak, James B. Schreiber
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Many discoveries in the biological sciences have emerged from observational studies, but student researchers also need to learn how to design experiments that distinguish correlation from causation. For example, identifying the physiological mechanis
Externí odkaz:
https://doaj.org/article/dcbac27fc8144fbdbb1c5d59d8abdb9d
Autor:
Thomas Uray, Cameron Dezfulian, Abigail A. Palmer, Kristin M. Miner, Rehana K. Leak, Jason P. Stezoski, Keri Janesko‐Feldman, Patrick M. Kochanek, Tomas Drabek
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 5 (2021)
Background Current postresuscitative care after cardiac arrest (CA) does not address the cause of CA. We previously reported that asphyxial CA (ACA) and ventricular fibrillation CA (VFCA) elicit unique injury signatures. We hypothesized that the earl
Externí odkaz:
https://doaj.org/article/d62d95d93cc243bfa7def83aa2a0f282
Autor:
Tuo Yang, Yang Sun, Leilei Mao, Meijuan Zhang, Qianqian Li, Lili Zhang, Yejie Shi, Rehana K. Leak, Jun Chen, Feng Zhang
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 323-337 (2018)
Brain ischemic preconditioning (IPC) with mild ischemic episodes is well known to protect the brain against subsequent ischemic challenges. However, the underlying mechanisms are poorly understood. Here we demonstrate the critical role of the master
Externí odkaz:
https://doaj.org/article/855c95a43f974b4c9ddc4c01cb084ead
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
Abstract The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into deat
Externí odkaz:
https://doaj.org/article/a318188482ab475495017ca01732f8fa
Autor:
Tarun N. Bhatia, Deepti B. Pant, Elizabeth A. Eckhoff, Rachel N. Gongaware, Timothy Do, Daniel F. Hutchison, Amanda M. Gleixner, Rehana K. Leak
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
In order to fulfill their evolutionary role as support cells, astrocytes have to tolerate intense oxidative stress under conditions of brain injury and disease. It is well known that astrocytes exposed to mild oxidative stress are preconditioned agai
Externí odkaz:
https://doaj.org/article/44967618233b4c5fa0955b92d1a73725