Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rehan Villani"'
Autor:
Edwige Roy, Ho Yi Wong, Rehan Villani, Thomas Rouille, Basit Salik, Seen Ling Sim, Valentine Murigneux, Mitchell S. Stark, J. Lynn Fink, H. Peter Soyer, Graeme Walker, J. Guy Lyons, Nicholas Saunders, Kiarash Khosrotehrani
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: To better understand the influence of ultraviolet (UV) irradiation on the initial steps of skin carcinogenesis, we examine patches of labeled keratinocytes as a proxy for clones in the interfollicular epidermis (IFE) and measure their size v
Externí odkaz:
https://doaj.org/article/4f40b994e84b446fa257776011c077e1
Autor:
Jessica C. Kling, Margaret A. Jordan, Lauren A. Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T. K. Nguyen, Deepak Mittal, Rehan Villani, Raymond J. Steptoe, Kiarash Khosrotehrani, Stuart P. Berzins, Alan G. Baxter, Dale I. Godfrey, Antje Blumenthal
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity. Interferon gamma (IFN-γ) and IL-4 are key cytokines rapidly produced by NKT cells upo
Externí odkaz:
https://doaj.org/article/4c72b58f73b64ff4b2d43b728cc74118
Autor:
Brandon J. Wainwright, Rehan Villani, Mathias Francois, Edwige Roy, Kiarash Khosrotehrani, Seen Ling Sim
Publikováno v:
Journal of Dermatological Science. 98:179-185
Background Basal Cell Carcinoma is the most common tumour and yet much remains to be determined regarding the molecular mechanisms that leads to its development. Hedgehog signal activation is sufficient for BCC induction, but the molecular mediators
Autor:
B. Baz, Herlina Y. Handoko, Jack A. Galbraith, Graeme J. Walker, Rehan Villani, Ayaka Johnson, Kiarash Khosrotehrani
Publikováno v:
Experimental Dermatology. 29:450-461
Mouse dorsal coat hair types, guard, awl, auchene and zigzag, develop in three consecutive waves. To date, it is unclear if these hair types are determined genetically through expression of specific factors or can change based on their mesenchymal en
Autor:
Edwige Roy, Rehan Villani, Kiarash Khosrotehrani, Seen-Ling Sim, J. Lynn Fink, Michael Wagels, Sergey Nikolaev, H. Peter Soyer, Josue Alexis, Valentine Murigneux, Nicholas A. Saunders, Laurent Parmentier
Publikováno v:
The Journal of investigative dermatology. 141(10)
Little is known regarding the molecular differences between basal cell carcinoma (BCC) subtypes, despite clearly distinct phenotypes and clinical outcomes. In particular, infiltrative BCCs have poorer clinical outcomes in terms of response to therapy
Autor:
Mathias Francois, Christelle Adolphe, Cathy Pichol-Thievend, Samantha Hodgson, Ho Yi Wong, Brandon Wainwight, Julien M. D. Legrand, Jessica Greaney, Rehan Villani, Kiarash Khosrotehrani
Publikováno v:
Development. 144:1887-1895
SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear. Here, we demonstrate that Sox18 regulates the normal differentiation of the de
Autor:
Kiarash Khosrotehrani, J.Lynn Flink, Stuti Kapadia, Jack Galbraith, Christiane Malapitan, Seen Ling Sim, Valentine Murigneux, Rehan Villani, Edwige Roy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c8007963b6b5c0a06d9b4015e1d9da
https://doi.org/10.26226/morressier.5d4980d08fb7e44098e73042
https://doi.org/10.26226/morressier.5d4980d08fb7e44098e73042
Autor:
Haotian Yang, Xiaowen Liang, Rehan Villani, Michael S. Roberts, Min Tang, Haolu Wang, Matthew J. Simpson
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-10 (2018)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidati
Autor:
Rehan Villani, Kiarash Khosrotehrani
Publikováno v:
The British journal of dermatology. 177(6)
Autor:
Duncan Lambie, Rehan Villani, Brian Gabrielli, Graeme J. Walker, H. Peter Soyer, Wolter J. Mooi, Kiarash Khosrotehrani, Blake Ferguson, Pamela Mukhopadhyay, Herlina Y. Handoko, Arash Chitsazan, Grant Morahan
Publikováno v:
Journal of Investigative Dermatology, 138(4), 893-902. Nature Publishing Group
Chitsazan, A, Ferguson, B, Villani, R, Handoko, H Y, Mukhopadhyay, P, Gabrielli, B, Mooi, W J, Soyer, H P, Lambie, D, Khosrotehrani, K, Morahan, G & Walker, G J 2018, ' Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion ', Journal of Investigative Dermatology, vol. 138, no. 4, pp. 893-902 . https://doi.org/10.1016/j.jid.2017.10.032
Chitsazan, A, Ferguson, B, Villani, R, Handoko, H Y, Mukhopadhyay, P, Gabrielli, B, Mooi, W J, Soyer, H P, Lambie, D, Khosrotehrani, K, Morahan, G & Walker, G J 2018, ' Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion ', Journal of Investigative Dermatology, vol. 138, no. 4, pp. 893-902 . https://doi.org/10.1016/j.jid.2017.10.032
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a9b3eb98db326fca4cb17be074061f
https://research.vumc.nl/en/publications/95aef61f-5b2f-499e-88b1-6207ab951052
https://research.vumc.nl/en/publications/95aef61f-5b2f-499e-88b1-6207ab951052