Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants

Autor: Hebah A. Al-Khatib, Maria K. Smatti, Fatma H. Ali, Hadeel T. Zedan, Swapna Thomas, Muna N. Ahmed, Reham A. El-kahlout, Mashael A. Al Bader, Dina Elgakhlab, Peter V. Coyle, Laith J. Abu-Raddad, Asma A. Al Thani, Hadi M. Yassine

Publikováno v: iScience, Vol 25, Iss 11, Pp 105438- (2022)

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and unvaccinated individua

Externí odkaz: https://doaj.org/article/6562339c07ce412cafef476c342f015a

Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar

Autor: Mohammad R. Hasan, Mahesh K.R. Kalikiri, Faheem Mirza, Sathyavathi Sundararaju, Anju Sharma, Thabisile Xaba, Stephan Lorenz, Hiam Chemaitelly, Reham A. El-Kahlout, Kin Ming Tsui, Hadi M. Yassine, Peter V. Coyle, Abdullatif Al Khal, Roberto Bertollini, Mohamed H. Al Thani, Laith J. Abu-Raddad, Patrick Tang

Publikováno v: International Journal of Infectious Diseases, Vol 112, Iss , Pp 52-54 (2021)

Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves of COVID-19 in Qatar, PCR gen

Externí odkaz: https://doaj.org/article/5b92bed673c34a429f3266981bf579a9

One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar

Autor: Fatiha M. Benslimane, Hebah A. Al Khatib, Ola Al-Jamal, Dana Albatesh, Sonia Boughattas, Ayeda A Ahmed, Meryem Bensaad, Shameem Younuskunju, Yasmin A. Mohamoud, Mashael Al Badr, Abdalla A. Mohamed, Reham A. El-Kahlout, Tasneem Al-Hamad, Dina Elgakhlab, Fatima H. Al-Kuwari, Chadi Saad, Andrew Jeremijenko, Abdullatif Al-Khal, Muna A. Al-Maslamani, Roberto Bertollini, Einas A. Al-Kuwari, Hamad E. Al-Romaihi, Salih Al-Marri, Mohammed Al-Thani, Radja M. Badji, Hamdi Mbarek, Yasser Al-Sarraj, Joel A. Malek, Said I. Ismail, Laith J. Abu-Raddad, Peter V. Coyle, Asmaa A. Al Thani, Hadi M. Yassine

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected pa

Externí odkaz: https://doaj.org/article/9bc184c8503742488eed928ed0480af6

Herd Immunity against Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 10 Communities, Qatar

Autor: Abdullatif Al Khal, Mohamed Ghaith Al Kuwari, Reham Awni El Kahlout, Naseer Ahmad Masoodi, Adeel A. Butt, Riyazuddin Mohammad Shaik, Anil George Thomas, Anvar Hassan Kaleeckal, Hiam Chemaitelly, Hanaa Nafady-Hego, Nourah Younes, Mohamed H. Al-Thani, Ahmed Al-Mohammed, Moza Alishaq, Huda Mohamad Al Naomi, Ali Nizar Latif, Abdul-Badi Abou-Samra, Einas Al Kuwari, Naema Hassan Abdulla Al Molawi, Jameela Ali A.A. Al Ajmi, Zaina Al Kanaani, Laith J. Abu-Raddad, Peter Coyle, Houssein H. Ayoub, Andrew Jeremijenko, Hadi M. Yassine, Hamad Eid Al Romaihi, Roberto Bertollini, Imtiaz Gillani, Hanan F. Abdul Rahim, Nasser Ali Asad Al Ansari

Publikováno v: Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1343-1352 (2021)
Emerging Infectious Diseases

We investigated what proportion of the population acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and whether the herd immunity threshold has been reached in 10 communities in Qatar. The study included 4,970 participan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c26ac1a3a75413f9aaae85abc7797
https://doi.org/10.3201/eid2705.204365

Reporting of RT-PCR cycle threshold (Ct) values during the first wave of COVID-19 in Qatar improved result interpretation in clinical and public health settings

Autor: Peter V. Coyle, Naema Hassan Al Molawi, Mohamed Ali Ben Hadj Kacem, Reham Awni El Kahlout, Einas Al Kuwari, Abdullatif Al Khal, Imtiaz Gillani, Andrew Jeremijenko, Hatoun Saeb, Mohammad Al Thani, Roberto Bertollini, Hanan F. Abdul Rahim, Hiam Chemaitelly, Patrick Tang, Ali Nizar Latif, Saad Al Kaabi, Muna A. Rahman S. Al Maslamani, Brendan David Morris, Nasser Al-Ansari, Anvar Hassan Kaleeckal, Laith J. Abu Raddad

Publikováno v: Coyle, P V, Al Molawi, N H, Kacem, M A B H, El Kahlout, R A, Al Kuwari, E, Al Khal, A, Gillani, I, Jeremijenko, A, Saeb, H, Al Thani, M, Bertollini, R, Abdul Rahim, H F, Chemaitelly, H, Tang, P, Latif, A N, Al Kaabi, S, Al Maslamani, M A R S, Morris, B D, Al-Ansari, N, Kaleeckal, A H & Abu Raddad, L J 2022, ' Reporting of RT-PCR cycle threshold (Ct) values during the first wave of COVID-19 in Qatar improved result interpretation in clinical and public health settings ', Journal of Medical Microbiology, vol. 71, no. 5, 001499 . https://doi.org/10.1099/jmm.0.001499

Introduction. The cycle threshold (Ct) value in real-time PCR (RT-PCR) is where a target-specific amplification signal becomes detectable and can infer viral load, risk of transmission and recovery. Use of Ct values in routine practice is uncommon. G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dbe016c20f97f888a2779214ab1547
https://doi.org/10.1099/jmm.0.001499