New approach methodologies in human regulatory toxicology – Not if, but how and when!

Autor: Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Wibke Busch, Christian Desaintes, Anne Gourmelon, Roland Grafström, Joshua Harrill, Thomas Hartung, Matthias Herzler, George E.N. Kass, Nicole Kleinstreuer, Marcel Leist, Mirjam Luijten, Philip Marx-Stoelting, Oliver Poetz, Bennard van Ravenzwaay, Rob Roggeband, Vera Rogiers, Adrian Roth, Pascal Sanders, Russell S. Thomas, Anne Marie Vinggaard, Mathieu Vinken, Bob van de Water, Andreas Luch, Tewes Tralau

Publikováno v: Environment International, Vol 178, Iss , Pp 108082- (2023)

The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance, sustainability, continued relevance for human health risk assessment and ethics of this system,

Externí odkaz: https://doaj.org/article/f976f541aefc4b4e8d0e30fa3b873d98

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Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams

Autor: Alexandra C. Cordova, William D. Klaren, Lucie C. Ford, Fabian A. Grimm, Erin S. Baker, Yi-Hui Zhou, Fred A. Wright, Ivan Rusyn

Publikováno v: Toxics, Vol 11, Iss 7, p 586 (2023)

Human cell-based test methods can be used to evaluate potential hazards of mixtures and products of petroleum refining (“unknown or variable composition, complex reaction products, or biological materials” substances, UVCBs). Analyses of bioactiv

Externí odkaz: https://doaj.org/article/f9599d4b1d4744b2b10ad3a3b4d6c3ac

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

Autor: Lola Bajard, Ondrej Adamovsky, Karine Audouze, Kirsten Baken, Robert Barouki, Joost B. Beltman, Anna Beronius, Eva Cecilie Bonefeld-Jørgensen, German Cano-Sancho, Milo L. de Baat, Filippo Di Tillio, Mariana F. Fernández, Rex E. FitzGerald, Claudia Gundacker, Antonio F. Hernández, Klara Hilscherova, Spyros Karakitsios, Eliska Kuchovska, Manhai Long, Mirjam Luijten, Sanah Majid, Philip Marx-Stoelting, Vicente Mustieles, Chander K. Negi, Dimosthenis Sarigiannis, Stefan Scholz, Iva Sovadinova, Rob Stierum, Shihori Tanabe, Knut Erik Tollefsen, Annick D. van den Brand, Carolina Vogs, Maria Wielsøe, Clemens Wittwehr, Ludek Blaha

Publikováno v: Environmental Research
Environmental Research. Elsevier BV
Bajard, L, Adamovsky, O, Audouze, K, Baken, K, Barouki, R, Beltman, J B, Beronius, A, Bonefeld-Jørgensen, E C, Cano-Sancho, G, de Baat, M L, Di Tillio, F, Fernández, M F, FitzGerald, R E, Gundacker, C, Hernández, A F, Hilscherova, K, Karakitsios, S, Kuchovska, E, Long, M, Luijten, M, Majid, S, Marx-Stoelting, P, Mustieles, V, Negi, C K, Sarigiannis, D, Scholtz, S, Sovadinova, I, Stierum, R, Tanabe, S, Tollefsen, K E, van den Brand, A D, Vogs, C, Wielsøe, M, Wittwehr, C & Blaha, L 2023, ' Application of AOPs to assist regulatory assessment of chemical risks-Case studies, needs and recommendations ', Environmental Research, vol. 217, 114650 . https://doi.org/10.1016/j.envres.2022.114650

While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1237a39508f13a4f75cb37a29540292

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