Výsledky vyhledávání - "Regulatory T cell differentiation"

Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β

Autor: Pyeung-Hyeun Kim, Geun-Shik Lee, Seok-Rae Park, Ha-Eon Song, Seung-Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Goo-Young Seo, Young-Saeng Jang, Tae-Gyu Kim, Hui-Won Park, Sun-Hee Park, Hyeon-Ju Jo

Publikováno v: The Journal of Immunology. 207:2456-2464

Lactoferrin (LF) is known to possess anti-inflammatory activity, although its mechanisms of action are not well-understood. The present study asked whether LF affects the commitment of inducible regulatory T cells (Tregs). LF substantially promoted F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16cf1919487074f9d8f4d4f3f90337d
https://doi.org/10.4049/jimmunol.2100326

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Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancer

Autor: Qi-rong Xu, Hong-Ying Liao, Bentong Yu, Jian Tang, Xiang-Yuan He, Sheng Liu, Yu-Zhen Zheng

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Journal of Translational Medicine

Background Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in relation to the regulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49d6714d3c096886b3b7c89823eecac
https://doaj.org/article/a34db8b7e02a4a5d93f87d03795a5002

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Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Autor: Alexandra L. Garnham, Christoph Thelemann, Lynn M. Corcoran, Kohei Kometani, Tom Sidwell, Wei Shi, David Chisanga, Christian R. Engwerda, Ajithkumar Vasanthakumar, Renee Gloury, Peggy P Teh, Gordon K. Smyth, Fabian de Labastida Rivera, Jonas Blume, Yang Liao, Tomohiro Kurosaki, Axel Kallies

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; however, molecular mechanisms that govern these processes are incompletely understood. Here we show that Bach2 is an importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e47ce84165124b7c1e9e74bdb06ee6d
https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e

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Heme-Oxygenase-1 Attenuates Oxidative Functions of Antigen Presenting Cells and Promotes Regulatory T Cell Differentiation during Fasciola hepatica Infection

Autor: Pablo Lores, Valeria da Costa, Santiago A. Rodríguez-Zraquia, Paula Carasi, Sofía Frigerio, Teresa Freire, Monique Costa, María Florencia Festari, Mercedes Landeira

Publikováno v: Antioxidants; Volume 10; Issue 12; Pages: 1938
Antioxidants
REDI
Agencia Nacional de Investigación e Innovación
instacron:Agencia Nacional de Investigación e Innovación
Antioxidants, Vol 10, Iss 1938, p 1938 (2021)

Fasciola hepatica is a fluke that infects livestock and humans causing fasciolosis, a zoonotic disease of increasing importance due to its worldwide distribution and high economic losses. The parasite regulates the host immune system by inducing a st

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Regulatory T cell differentiation is controlled by alpha KG-induced alterations in mitochondrial metabolism and lipid homeostasis

Publikováno v: Cell Reports
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)

Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of naive CD4 T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a0285e83f2c785c903977fe07dec51
https://lirias.kuleuven.be/handle/20.500.12942/691431

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BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation

Autor: Molly Javier Uyeda, Robert A. Freeborn, Brandon Cieniewicz, Rosa Romano, Ping (Pauline) Chen, Jeffrey Mao-Hwa Liu, Benjamin Thomas, Esmond Lee, Alma-Martina Cepika, Rosa Bacchetta, Maria Grazia Roncarolo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology

Type 1 regulatory T (Tr1) cells are subset of peripherally induced antigen-specific regulatory T cells. IL-10 signaling has been shown to be indispensable for polarization and function of Tr1 cells. However, the transcriptional machinery underlying h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cc5502f49f6fc1d82f536bc4298267
https://www.frontiersin.org/articles/10.3389/fimmu.2021.683680/full

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Tangeretin promotes regulatory T cell differentiation by inhibiting Notch1/Jagged1 signaling in allergic rhinitis

Autor: Rui Yang, Shan Xu, Wo-Er Jiao, Yue-Long Qiao, Yu Xu, Yonggang Kong, Shi-Ming Chen, Zezhang Tao

Publikováno v: International Immunopharmacology. 72:402-412

Background and objective Tangeretin demonstrates broad anti-inflammatory effects. The present study aimed to assess whether tangeretin functions in regulating T-regulatory cells (Tregs) and alleviating allergic rhinitis (AR). Methods An ovalbumin (OV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7c68759543e86611d9832dc94ade95
https://doi.org/10.1016/j.intimp.2019.04.039

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miR-146a enhances regulatory T-cell differentiation and function in allergic rhinitis by targeting STAT5b

Autor: Xicheng Song, Limei Cui, Liping Yang, Yujuan Yang, Jing Guo, Luo Zhang, Yu Zhang, Yakui Mou, Chuanliang Jia, Yumei Li

Publikováno v: AllergyREFERENCES. 77(2)

Background MicroRNA (miR)-146a, as an important immune regulatory factor with an anti-inflammatory effect, plays a crucial role in regulatory T cells (Tregs) differentiation and function in allergic rhinitis (AR). The present study aimed to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725510115f4a87f1f5249bde6ad3b280
https://pubmed.ncbi.nlm.nih.gov/34716993

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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation

Autor: Wei Yan, Yi-Si Zhao, Yu Xing, Ke Xie, Fang Xu

Publikováno v: Journal of Immunology Research
Journal of Immunology Research, Vol 2021 (2021)

Purpose. Aspergillus fumigatus, as an opportunistic fungus, has developed a series of escape mechanisms under the host’s immune response to obtain nutrients and promote fungal growth in the hostile environment. The immune escape of pathogens may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1863f49c62df5603e06428cee8379cc8
http://europepmc.org/articles/PMC8219420

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'Go', 'No Go,' or 'Where to Go'; does microbiota dictate T cell exhaustion, programming, and HIV persistence?

Autor: Ashish Sharma, Susan Pereira Ribeiro, Sudhanshu Shukla, Sangeeta Kumari, Saswat K. Bal, Daniela C. Monaco, Rafick-Pierre Sekaly

Publikováno v: Current opinion in HIV and AIDS. 16(4)

PURPOSE OF REVIEW People living with HIV who fail to fully reconstitute CD4+T cells after combination antiretroviral therapy therapy (i.e. immune nonresponders or INRs) have higher frequencies of exhausted T cells are enriched in a small pool of memo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10f8f7416a2613ead2deb0a40435712
https://pubmed.ncbi.nlm.nih.gov/34039845

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