Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer

Autor: Xin Jin, Wenke Jin, Linlin Tong, Jia Zhao, Lan Zhang, Na Lin

Publikováno v: Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2815-2853 (2024)

Regulated cell death (RCD) is a controlled form of cell death orchestrated by one or more cascading signaling pathways, making it amenable to pharmacological intervention. RCD subroutines can be categorized as apoptotic or non-apoptotic and play esse

Externí odkaz: https://doaj.org/article/0881ed82ae084982ab8caa3190444a8b

Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy

Autor: Yingying Shao, Yu Wang, Ranran Su, Weiling Pu, Sibao Chen, Leilei Fu, Haiyang Yu, Yuling Qiu

Publikováno v: Heliyon, Vol 9, Iss 7, Pp e17582- (2023)

Tumor-associated macrophage (TAM) affects the intrinsic properties of tumor cells and the tumor microenvironment (TME), which can stimulate tumor cell proliferation, migration, and genetic instability, and macrophage diversity includes the diversity

Externí odkaz: https://doaj.org/article/6a48e40aee5743a2a09bc5379a92847f

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

Autor: Rui Qin, Feng-Ming You, Qian Zhao, Xin Xie, Cheng Peng, Gu Zhan, Bo Han

Publikováno v: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-49 (2022)

Abstract Regulated cell death (RCD) is a critical and active process that is controlled by specific signal transduction pathways and can be regulated by genetic signals or drug interventions. Meanwhile, RCD is closely related to the occurrence and th

Externí odkaz: https://doaj.org/article/2effabe59bb24f469761afe92af68337

Cellular Senescence and Regulated Cell Death of Tubular Epithelial Cells in Diabetic Kidney Disease

Autor: Shuang Shen, Chuanyuan Ji, Kaifeng Wei

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Cellular senescence is frequently evident at etiologic sites of chronic diseases and involves essentially irreversible arrest of cell proliferation, increased protein production, resistance to apoptosis, and altered metabolic activity. Regulated cell

Externí odkaz: https://doaj.org/article/78a29d8587d64fdfb6303ab17fc93d9a

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Autor: Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J M, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D'Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Kluck, Ruth, Krysko, Dmitri V, Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N, Lemasters, John J, Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J, Martinou, Jean-Claude, Mastroberardino, Pier G, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A, Moll, Ute M, Muñoz-Pinedo, Cristina, Murphy, Daniel J, Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T, Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M, Pentimalli, Francesca, Pereira, David M, Pervaiz, Shazib, Peter, Marcus E, Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H M, Puthalakath, Hamsa, Rabinovich, Gabriel A, Rajalingam, Krishnaraj, Ravichandran, Kodi S, Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M P, Rotblat, Barak, Rothlin, Carla V, Rubinsztein, David C, Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M, Sarosiek, Kristopher A, Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R, Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W G, Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M, Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G, Vanderluit, Jacqueline L, Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K, Vousden, Karen H, Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F, Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E, Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo

Publikováno v: Vitale, I, Pietrocola, F, Guilbaud, E, Aaronson, S A, Abrams, J M, Adam, D, Agostini, M, Agostinis, P, Alnemri, E S, Altucci, L, Amelio, I, Andrews, D W, Aqeilan, R I, Arama, E, Baehrecke, E H, Balachandran, S, Bano, D, Barlev, N A, Bartek, J, Bazan, N G, Becker, C, Bernassola, F, Bertrand, M J M, Bianchi, M E, Blagosklonny, M V, Blander, J M, Blandino, G, Blomgren, K, Borner, C, Bortner, C D, Bove, P, Boya, P, Brenner, C, Broz, P, Brunner, T, Damgaard, R B, Calin, G A, Campanella, M, Candi, E, Carbone, M, Carmona-Gutierrez, D, Cecconi, F, Chan, F K M, Chen, G Q, Chen, Q, Chen, Y H, Cheng, E H, Chipuk, J E, Cidlowski, J A, Ciechanover, A, Ciliberto, G, Conrad, M, Cubillos-Ruiz, J R, Czabotar, P E, D’Angiolella, V, Daugaard, M, Dawson, T M, Dawson, V L, De Maria, R, De Strooper, B, Debatin, K M, Deberardinis, R J, Degterev, A, Del Sal, G, Deshmukh, M, Di Virgilio, F, Diederich, M, Dixon, S J, Dynlacht, B D, El-Deiry, W S, Elrod, J W, Engeland, K, Fimia, G M, Galassi, C, Ganini, C, Garcia-Saez, A J, Garg, A D, Garrido, C, Gavathiotis, E, Gerlic, M, Ghosh, S, Green, D R, Greene, L A, Gronemeyer, H, Häcker, G, Hajnóczky, G, Hardwick, J M, Haupt, Y, He, S, Heery, D M, Hengartner, M O, Hetz, C, Hildeman, D A, Ichijo, H, Inoue, S, Jäättelä, M, Janic, A, Joseph, B, Jost, P J, Kanneganti, T D, Karin, M, Kashkar, H, Kaufmann, T, Kelly, G L, Kepp, O, Kimchi, A, Kitsis, R N, Klionsky, D J, Kluck, R, Krysko, D V, Kulms, D, Kumar, S, Lavandero, S, Lavrik, I N, Lemasters, J J, Liccardi, G, Linkermann, A, Lipton, S A, Lockshin, R A, López-Otín, C, Luedde, T, MacFarlane, M, Madeo, F, Malorni, W, Manic, G, Mantovani, R, Marchi, S, Marine, J C, Martin, S J, Martinou, J C, Mastroberardino, P G, Medema, J P, Mehlen, P, Meier, P, Melino, G, Melino, S, Miao, E A, Moll, U M, Muñoz-Pinedo, C, Murphy, D J, Niklison-Chirou, M V, Novelli, F, Núñez, G, Oberst, A, Ofengeim, D, Opferman, J T, Oren, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, J M, Pentimalli, F, Pereira, D M, Pervaiz, S, Peter, M E, Pinton, P, Porta, G, Prehn, J H M, Puthalakath, H, Rabinovich, G A, Rajalingam, K, Ravichandran, K S, Rehm, M, Ricci, J E, Rizzuto, R, Robinson, N, Rodrigues, C M P, Rotblat, B, Rothlin, C V, Rubinsztein, D C, Rudel, T, Rufini, A, Ryan, K M, Sarosiek, K A, Sawa, A, Sayan, E, Schroder, K, Scorrano, L, Sesti, F, Shao, F, Shi, Y, Sica, G S, Silke, J, Simon, H U, Sistigu, A, Stephanou, A, Stockwell, B R, Strapazzon, F, Strasser, A, Sun, L, Sun, E, Sun, Q, Szabadkai, G, Tait, S W G, Tang, D, Tavernarakis, N, Troy, C M, Turk, B, Urbano, N, Vandenabeele, P, Vanden Berghe, T, Vander Heiden, M G, Vanderluit, J L, Verkhratsky, A, Villunger, A, von Karstedt, S, Voss, A K, Vousden, K H, Vucic, D, Vuri, D, Wagner, E F, Walczak, H, Wallach, D, Wang, R, Wang, Y, Weber, A, Wood, W, Yamazaki, T, Yang, H T, Zakeri, Z, Zawacka-Pankau, J E, Zhang, L, Zhang, H, Zhivotovsky, B, Zhou, W, Piacentini, M, Kroemer, G & Galluzzi, L 2023, ' Apoptotic cell death in disease—Current understanding of the NCCD 2023 ', Cell Death and Differentiation, vol. 30, no. 5, pp. 1097-1154 . https://doi.org/10.1038/s41418-023-01153-w
Cell death and differentiation 30(5), 1097-1154 (2023). doi:10.1038/s41418-023-01153-w

58 p.-5 fig.-7 box.
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2b742266215ffe65e96dc332753aba
https://orbit.dtu.dk/en/publications/0f60f683-cf55-4ff1-9d52-631620c6ad87