Zobrazeno 1 - 10
of 374
pro vyhledávání: '"Regis J, O'Keefe"'
Autor:
Julie Jin, MD, Zachery Hong, MD, MPHS, Lee Rhea, PhD, Douglas J. McDonald, MD, Regis J. O’Keefe, MD, PhD, Cara A. Cipriano, MD, MSc
Publikováno v:
JBJS Open Access, Vol 8, Iss 3 (2023)
Background:. The Toronto Extremity Salvage Score (TESS) and the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) are both utilized to measure patient-reported outcomes in adults with musculoskeletal onco
Externí odkaz:
https://doaj.org/article/c66b4405af664ee59dae77f1c46b0754
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Glucose metabolism is fundamental for the functions of all tissues, including cartilage. Despite the emerging evidence related to glucose metabolism in the regulation of prenatal cartilage development, little is known about the role of gluco
Externí odkaz:
https://doaj.org/article/bb34989454114b979a69de69e5dd06c0
Autor:
Manoj Arra, Gaurav Swarnkar, Ke Ke, Jesse E. Otero, Jun Ying, Xin Duan, Takashi Maruyama, Muhammad Farooq Rai, Regis J. O’Keefe, Gabriel Mbalaviele, Jie Shen, Yousef Abu-Amer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Chondrocytes have altered cellular metabolism in the context of osteoarthritis, but whether and how these changes are associated with inflammation is a controversial area. Here the authors show that inflammatory NF-κB signalling drives a glycolytic
Externí odkaz:
https://doaj.org/article/85329ba61e30432694e6760ca1cad04a
Publikováno v:
Journal of Orthopaedic Translation, Vol 23, Iss , Pp 132-139 (2020)
Osteoarthritis (OA) is the most common form of arthritis, is the leading cause of impaired mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain. As a degenerative joint disorder, OA affects the whole joint an
Externí odkaz:
https://doaj.org/article/58bfbf7c22e243c688a84afd1c5773c5
Publikováno v:
Arthroplasty Today, Vol 4, Iss 4, Pp 431-435 (2018)
Intra-articular malignant lesions of the hip present significant challenges. Resection often requires large resection of the acetabular bone and pelvic columns. Concurrent reconstruction options after intra-articular hip tumors are challenging and ma
Externí odkaz:
https://doaj.org/article/70e260dd42384ded8f685405d1d4aa43
Publikováno v:
Journal of Orthopaedic Translation, Vol 27, Iss , Pp A1- (2021)
Externí odkaz:
https://doaj.org/article/07adbcda196b43bb8ae25f47ffae07a6
Publikováno v:
Clinical Orthopaedics & Related Research. 481:935-944
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5d10ddd57725414fbb876598ecaec04
https://doi.org/10.1097/corr.0000000000002555
https://doi.org/10.1097/corr.0000000000002555
Publikováno v:
Journal of Orthopaedic Translation, Vol 12, Iss C, Pp 66-73 (2018)
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles. At the cellul
Externí odkaz:
https://doaj.org/article/66eae1b173d14c1eacc896b517ded512
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Tendon injuries heal via scar tissue rather than regeneration. This healing response forms adhesions between the flexor tendons in the hand and surrounding tissues, resulting in impaired range of motion and hand function. Mechanistically, in
Externí odkaz:
https://doaj.org/article/930aa5bc24584e0e8f7273072e04ab6d
Autor:
Tomoyuki Kamenaga, Masahiko Haneda, Robert H. Brophy, Regis J. O’Keefe, John C. Clohisy, Cecilia Pascual-Garrido
Publikováno v:
Am J Sports Med
Background: Femoroacetabular impingement (FAI) is a leading cause of hip pain in young adults and often leads to degenerative osteoarthritis (OA). A small animal model of hip deformities is crucial for unraveling the pathophysiology of hip OA seconda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a471634bf50a1b43dd22b0916a6ed86a
https://doi.org/10.1177/03635465221090645
https://doi.org/10.1177/03635465221090645