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Catalase overexpression impairs TNF-α induced NF-κB activation and sensitizes MCF-7 cells against TNF-α

Autor: Yvonni Chovolou, Regine Lüpertz, Wim Wätjen, Andreas Kampkötter, Regine Kahl

Publikováno v: Journal of Cellular Biochemistry. 103:1497-1511

The pleiotropic cytokine tumor necrosis factor alpha (TNF-alpha) can induce apoptosis but also supports cell survival pathways. Among the possible anti-apoptotic mechanisms of TNF-alpha is the activation of the transcription factor NF-kappaB. Since r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd81da88166f6d0c7b9e7462ebee0826
https://doi.org/10.1002/jcb.21538

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Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans

Autor: Andreas Kampkötter, Yvonni Chovolou, Wim Wätjen, Regine Kahl, Christiane Gombitang Nkwonkam, Claudia Timpel, Ruben Felix Zurawski

Publikováno v: Toxicology. 234:113-123

Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence is regarded as a main factor in the pathophysiology of various diseases and ageing. Many flavonoids that are present in herbal e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485439112510ecb381e5f1175baf8097
https://doi.org/10.1016/j.tox.2007.02.006

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Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells

Autor: Yvonni Chovolou, Nadine Weber, Peter Proksch, Wim Wätjen, Andreas Kampkötter, Regine Kahl, Yijia Lou, Zhiqiang Wang

Publikováno v: Food and Chemical Toxicology. 45:119-124

Antioxidative as well as cytotoxic effects of the prenylated flavonoids licoflavone C (8-prenylapigenin) and isobavachin (8-prenylliquiritigenin) were investigated in comparison to the corresponding non-prenylated flavonoids (apigenin, liquiritigenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d34b13ad4ddbc1e77d621418f25982
https://doi.org/10.1016/j.fct.2006.08.008

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The REACH concept and its impact on toxicological sciences

Autor: Jan G. Hengstler, Heidi Foth, Regine Kahl, P.-J. Kramer, W. Lilienblum, T. Schulz, H. Schweinfurth

Publikováno v: Toxicology. 220:232-239

Currently, comprehensive toxicological data are available only for a small percentage of the 30,000 substances produced in volumes of 1-100 tons per year in the EU. Substances with inadequate safety data sets may pose a risk to employees, consumers a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af3ef3d010910cbe337e425ad50b7a63
https://doi.org/10.1016/j.tox.2005.12.005

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Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis

Autor: Gudrun Michels, Regine Kahl, Wim Wätjen, Yvonni Chovolou, Bärbel Steffan, Petra Niering, Andreas Kampkötter, Quynh-Hoa Tran-Thi, Peter Proksch

Publikováno v: The Journal of Nutrition. 135:525-531

Dietary flavonoids possess a wide spectrum of biochemical and pharmacological actions and are assumed to protect human health. These actions, however, can be antagonistic, and some health claims are mutually exclusive. The antiapoptotic actions of fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243f2cf2b3f9db9a7ba1325456fa1e43
https://doi.org/10.1093/jn/135.3.525

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Polyphenols from plants used in traditional Indonesian medicine (Jamu): uptake and antioxidative effects in rat H4IIE hepatoma cells

Autor: Peter Proksch, Regine Kahl, Bärbel Steffan, Victor Wray, Petra Niering, Wim Wätjen, Gudrun Michels, Rainer Ebel, RuAngelie Edrada

Publikováno v: Journal of Pharmacy and Pharmacology. 57:233-240

Phytochemical investigation of plants used in traditional Indonesian medicine (Jamu) yielded lignans (pinoresinol, 9α-hydroxypinoresinol and salicifoliol), flavonoids (3-β-D-glucopyranosyl-(1→6)-β-d-glucopyranosylkaempferol, luteolin and apigeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1a068217fcf00b0529e880aa637a39
https://doi.org/10.1211/0022357055317

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Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells

Autor: Regine Kahl, Yvonni Chovolou, Q-H Tran Thi, Gudrun Michels, Aalt Bast, Petra Niering, Andreas Kampkötter, Bärbel Steffan, Peter Proksch, Wim Wätjen

Publikováno v: Toxicology, 206(3), 337-348. Elsevier Ireland Ltd

Polyphenols are ubiquitous substances in the diet. Their anti-oxidative, anti-inflammatory and anti-viral effects are of interest for human health, and polyphenols such as luteolin are used at high concentrations in food supplements. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c91455517a7680e6f9b3902abed69d
https://doi.org/10.1016/j.tox.2004.07.022

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Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells

Autor: Regine Kahl, Wim Wätjen, Gisela H. Degen, Keiko Iwami, Ana Laura Di Virgilio

Publikováno v: Toxicology Letters. 151:151-162

Hormonally active chemicals in the human diet, such as man-made estrogenic chemicals or plant-derived compounds (phytoestrogens), have become a matter of public concern. A significant part of human exposure to phytoestrogens is attributable to soy is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc682d454eab8811c7e6dac63a328e76
https://doi.org/10.1016/j.toxlet.2004.04.005

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