Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Regine Heller"'
Autor:
Heena Doshi, Katrin Spengler, Amod Godbole, Yi Sing Gee, Jonathan Baell, Jonathan S. Oakhill, Andreas Henke, Regine Heller
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may
Externí odkaz:
https://doaj.org/article/9cbb143a3735452499080643bf1bfa2d
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2256 (2023)
Tumors are a highly heterogeneous mass of tissue showing distinct therapy responses. In particular, the therapeutic outcome of tumor hyperthermia treatments has been inconsistent, presumably due to tumor versus endothelial cell cross-talks related to
Externí odkaz:
https://doaj.org/article/0bff461abe674b299b83c5eecf039c89
Autor:
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects
Externí odkaz:
https://doaj.org/article/2a95d56d607f461daa73332371e24e27
Autor:
Julia Leonhardt, Raphael S. Haider, Christoph Sponholz, Silke Leonhardt, Julia Drube, Katrin Spengler, Diana Mihaylov, Sophie Neugebauer, Michael Kiehntopf, Nevin A. Lambert, Andreas Kortgen, Tony Bruns, Frank Tacke, Carsten Hoffmann, Michael Bauer, Regine Heller
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 25-40 (2021)
Background & Aims: Retention of bile acids in the blood is a hallmark of liver failure. Recent studies have shown that increased serum bile acid levels correlate with bacterial infection and increased mortality. However, the mechanisms by which circu
Externí odkaz:
https://doaj.org/article/f2898bb220504471a55ccd6030fbf158
Autor:
Leonie K. Stabenow, Darya Zibrova, Claudia Ender, Dario L. Helbing, Katrin Spengler, Christian Marx, Zhao-Qi Wang, Regine Heller
Publikováno v:
Cells, Vol 11, Iss 14, p 2213 (2022)
Vascular aging is based on the development of endothelial dysfunction, which is thought to be promoted by senescent cells accumulating in aged tissues and is possibly affected by their environment via inflammatory mediators and oxidative stress. Sene
Externí odkaz:
https://doaj.org/article/4e79ea5e59b34386911a38e499fdd768
Autor:
Stefanie Deinhardt-Emmer, Laura Jäckel, Clio Häring, Sarah Böttcher, Janine J. Wilden, Brigitte Glück, Regine Heller, Michaela Schmidtke, Mirijam Koch, Bettina Löffler, Stephan Ludwig, Christina Ehrhardt
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 808 (2021)
Influenza virus (IV) infections are considered to cause severe diseases of the respiratory tract. Beyond mild symptoms, the infection can lead to respiratory distress syndrome and multiple organ failure. Occurrence of resistant seasonal and pandemic
Externí odkaz:
https://doaj.org/article/8e9adfddb06a437c8fe58c7035a2da3d
Autor:
Trim Lajqi, Christian Marx, Hannes Hudalla, Fabienne Haas, Silke Große, Zhao-Qi Wang, Regine Heller, Michael Bauer, Reinhard Wetzker, Reinhard Bauer
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2578 (2021)
Microglia, the innate immune cells of the CNS, exhibit long-term response changes indicative of innate immune memory (IIM). Our previous studies revealed IIM patterns of microglia with opposing immune phenotypes: trained immunity after a low dose and
Externí odkaz:
https://doaj.org/article/341d6961a20e4a56bb9ad7b8a3a55490
Autor:
John Njeru, Falk Melzer, Gamal Wareth, Hosny El-Adawy, Klaus Henning, Mathias W. Pletz, Regine Heller, Samuel Kariuki, Eric M. Fèvre, Heinrich Neubauer
Publikováno v:
Emerging Infectious Diseases, Vol 22, Iss 12, Pp 2160-2164 (2016)
During 2014–2015, patients in northeastern Kenya were assessed for brucellosis and characteristics that might help clinicians identify brucellosis. Among 146 confirmed brucellosis patients, 29 (20%) had negative serologic tests. No clinical feature
Externí odkaz:
https://doaj.org/article/e405db4e407843e1805c303cf7932058
Autor:
Julia Leonhardt, Silke Große, Christian Marx, Fatina Siwczak, Sven Stengel, Tony Bruns, Reinhard Bauer, Michael Kiehntopf, David L. Williams, Zhao-Qi Wang, Alexander S. Mosig, Sebastian Weis, Michael Bauer, Regine Heller
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
β-Glucan derived from cell walls of Candida albicans is a potent immune modulator. It has been shown to induce trained immunity in monocytes via epigenetic and metabolic reprogramming and to protect from lethal sepsis if applied prior to infection.
Externí odkaz:
https://doaj.org/article/c2c38bd6e5574b3cba0d86f0e34270a5
Autor:
Karolin Heinze, Martin Hölzer, Martin Ungelenk, Melanie Gerth, Jürgen Thomale, Regine Heller, Claire R. Morden, Kirk J. McManus, Alexander S. Mosig, Matthias Dürst, Ingo B. Runnebaum, Norman Häfner
Publikováno v:
Cancers, Vol 13, Iss 3, p 476 (2021)
The prognosis of late-stage epithelial ovarian cancer (EOC) patients is affected by chemotherapy response and the malignant potential of the tumor cells. In earlier work, we identified hypermethylation of the runt-related transcription factor 3 gene
Externí odkaz:
https://doaj.org/article/e6718462ba774b10b367e3c0ce80add5