Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Regine Heilbronn"'
Autor:
Luca Zangrandi, Barbara Fogli, Anna Mutti, René Staritzbichler, Victoria Most, Peter W. Hildebrand, Regine Heilbronn, Christoph Schwarzer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects. Dyn also bind to mu (MOPr
Externí odkaz:
https://doaj.org/article/f369c9268e654a14b335b6273d0e7f09
Autor:
Jeanette Zanker, Daniela Hüser, Adrien Savy, Sara Lázaro-Petri, Eva-Maria Hammer, Christoph Schwarzer, Regine Heilbronn
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, in vitro testing of vector-derived transgene function can be challenging when specific post-translational modifications are needed fo
Externí odkaz:
https://doaj.org/article/0008ca48e46b43d6a58a16fb4f210f2f
Autor:
Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-16 (2019)
Abstract Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges. In the quest of novel, disease
Externí odkaz:
https://doaj.org/article/480489b3db774418b348f8ecb6933d15
Autor:
Jackie Lau, Aitak Farzi, Yue Qi, Regine Heilbronn, Mario Mietzsch, Yan-Chuan Shi, Herbert Herzog
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 102-118 (2018)
Objective: The cocaine- and amphetamine-regulated transcript (CART) codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART fun
Externí odkaz:
https://doaj.org/article/c9797eabe3dc4a67bdd5670806031a4a
Autor:
Bridget Lins-Austin, Saajan Patel, Mario Mietzsch, Dewey Brooke, Antonette Bennett, Balasubramanian Venkatakrishnan, Kim Van Vliet, Adam N. Smith, Joanna R. Long, Robert McKenna, Mark Potter, Barry Byrne, Sanford L. Boye, Brian Bothner, Regine Heilbronn, Mavis Agbandje-McKenna
Publikováno v:
Viruses, Vol 12, Iss 6, p 668 (2020)
Adeno-associated viruses (AAVs) are small, non-pathogenic ssDNA viruses being used as therapeutic gene delivery vectors for the treatment of a variety of monogenic diseases. An obstacle to successful gene delivery is inefficient capsid trafficking th
Externí odkaz:
https://doaj.org/article/c53fc790c6d747268e96cc1198cbcd18
Autor:
Renáta Tóth, István Mészáros, Daniela Hüser, Barbara Forró, Szilvia Marton, Ferenc Olasz, Krisztián Bányai, Regine Heilbronn, Zoltán Zádori
Publikováno v:
Viruses, Vol 11, Iss 1, p 38 (2019)
To analyze the methylation status of wild-type adeno-associated virus type 2 (AAV2), bisulfite PCR sequencing (BPS) of the packaged viral genome and its integrated form was performed and 262 of the total 266 CG dinucleotides (CpG) were mapped. In vir
Externí odkaz:
https://doaj.org/article/a795cd22baa4496184f4f9c93fb25dfa
Autor:
Catrin Stutika, Mario Mietzsch, Andreas Gogol-Döring, Stefan Weger, Madlen Sohn, Wei Chen, Regine Heilbronn
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161454 (2016)
Most DNA viruses express small regulatory RNAs, which interfere with viral or cellular gene expression. For adeno-associated virus (AAV), a small ssDNA virus with a complex biphasic life cycle miRNAs or other small regulatory RNAs have not yet been d
Externí odkaz:
https://doaj.org/article/d2713c58ea904d12a7e5e3628cdb3622
Autor:
Mark Potter, Bridget Lins, Mario Mietzsch, Regine Heilbronn, Kim Van Vliet, Paul Chipman, Mavis Agbandje-McKenna, Brian D Cleaver, Nathalie Clément, Barry J Byrne, Sergei Zolotukhin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
We describe a new rapid, low cost, and scalable method for purification of various recombinant adeno-associated viruses (rAAVs) from the lysates of producer cells of either mammalian or insect origin. The method takes advantage of two general biochem
Externí odkaz:
https://doaj.org/article/c17f51f63f434046bfc638662e57c782
Autor:
Anna Osiak, Frank Radecke, Eva Guhl, Sarah Radecke, Nadine Dannemann, Fabienne Lütge, Silke Glage, Cornelia Rudolph, Tobias Cantz, Klaus Schwarz, Regine Heilbronn, Toni Cathomen
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28911 (2011)
Gene knockout in murine embryonic stem cells (ESCs) has been an invaluable tool to study gene function in vitro or to generate animal models with altered phenotypes. Gene targeting using standard techniques, however, is rather inefficient and typical
Externí odkaz:
https://doaj.org/article/368166d969e343d6b3056ac64ca6a795
Autor:
Daniela Hüser, Andreas Gogol-Döring, Timo Lutter, Stefan Weger, Kerstin Winter, Eva-Maria Hammer, Toni Cathomen, Knut Reinert, Regine Heilbronn
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1000985 (2010)
Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration in human chromosome 19q13.42. The AAV non-structural protein Rep appears to target a site called AAVS1 by simultaneously binding to Rep-binding sites (RBS)
Externí odkaz:
https://doaj.org/article/eb0261c9c280413a82730aee381124c9