Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Regine C. Tölle"'
Autor:
Marina Spörrer, Ania Prochnicki, Regine C. Tölle, Alexander Nyström, Philipp R. Esser, Melanie Homberg, Ioannis Athanasiou, Eleni Zingkou, Achim Schilling, Richard Gerum, Ingo Thievessen, Lilli Winter, Leena Bruckner-Tuderman, Ben Fabry, Thomas M. Magin, Jörn Dengjel, Rolf Schröder, Dimitra Kiritsi
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 502-515 (2019)
Background: Missense mutations in keratin 5 and 14 genes cause the severe skin fragility disorder epidermolysis bullosa simplex (EBS) by collapsing of the keratin cytoskeleton into cytoplasmic protein aggregates. Despite intense efforts, no molecular
Externí odkaz:
https://doaj.org/article/47ea7f55341e4d9da82e524620743e82
Autor:
Sabrina Schroeder, Sebastian J. Hofer, Andreas Zimmermann, Raimund Pechlaner, Christopher Dammbrueck, Tobias Pendl, G. Mark Marcello, Viktoria Pogatschnigg, Martina Bergmann, Melanie Müller, Verena Gschiel, Selena Ristic, Jelena Tadic, Keiko Iwata, Gesa Richter, Aitak Farzi, Muammer Üçal, Ute Schäfer, Michael Poglitsch, Philipp Royer, Ronald Mekis, Marlene Agreiter, Regine C. Tölle, Péter Sótonyi, Johann Willeit, Barbara Mairhofer, Helga Niederkofler, Irmgard Pallhuber, Gregorio Rungger, Herbert Tilg, Michaela Defrancesco, Josef Marksteiner, Frank Sinner, Christoph Magnes, Thomas R. Pieber, Peter Holzer, Guido Kroemer, Didac Carmona-Gutierrez, Luca Scorrano, Jörn Dengjel, Tobias Madl, Simon Sedej, Stephan J. Sigrist, Bence Rácz, Stefan Kiechl, Tobias Eisenberg, Frank Madeo
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108985- (2021)
Summary: Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary
Externí odkaz:
https://doaj.org/article/39e2c2e4dbb64f9d873d1cd5180f9ef8
Autor:
Piero Dalle Pezze, Stefanie Ruf, Annika G. Sonntag, Miriam Langelaar-Makkinje, Philip Hall, Alexander M. Heberle, Patricia Razquin Navas, Karen van Eunen, Regine C. Tölle, Jennifer J. Schwarz, Heike Wiese, Bettina Warscheid, Jana Deitersen, Björn Stork, Erik Fäßler, Sascha Schäuble, Udo Hahn, Peter Horvatovich, Daryl P. Shanley, Kathrin Thedieck
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ su
Externí odkaz:
https://doaj.org/article/4a285de016fb4d67ada2a43c868dc313
Autor:
Leena Bruckner-Tuderman, Regine C Tölle, Jörn Dengjel, Julia Donauer, Christine Gretzmeier, Esther Martínez-Martínez
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology.
In recessive dystrophic epidermolysis bullosa (RDEB), loss of collagen VII, the main component of anchoring fibrils critical for epidermal-dermal cohesion, affects several intracellular signaling pathways and leads to impaired wound healing and fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b07752bc39ce9a5d18919a4ad85d1b0
https://pubmed.ncbi.nlm.nih.gov/34706254
https://pubmed.ncbi.nlm.nih.gov/34706254
Autor:
Richard Gerum, Regine C Tölle, Philipp R. Esser, Lilli Winter, Ingo Thievessen, Ioannis Athanasiou, Rolf Schröder, Eleni Zingkou, Ben Fabry, Ania Prochnicki, Jörn Dengjel, Alexander Nyström, Dimitra Kiritsi, Thomas M. Magin, Leena Bruckner-Tuderman, Marina Spörrer, Achim Schilling, Melanie Homberg
Background Missense mutations in keratin 5 and 14 genes cause the severe skin fragility disorder epidermolysis bullosa simplex (EBS) by collapsing of the keratin cytoskeleton into cytoplasmic protein aggregates. Despite intense efforts, no molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201d7baf1f3ee4ed62db4095bb786b77
http://doc.rero.ch/record/326948/files/toe_tkw_sm.pdf
http://doc.rero.ch/record/326948/files/toe_tkw_sm.pdf
Autor:
Regine C, Tölle, Jörn, Dengjel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1993
The cellular microenvironment often plays a crucial role in disease development and progression. In recessive dystrophic epidermolysis bullosa (RDEB), biallelic mutations of the gene COL7A1, encoding for collagen VII, the main component of anchoring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e02bffdcda8f54e3ce4954e97257f32
https://pubmed.ncbi.nlm.nih.gov/31148088
https://pubmed.ncbi.nlm.nih.gov/31148088
Autor:
Regine C Tölle, Jörn Dengjel
Publikováno v:
Skin Tissue Engineering ISBN: 9781493994724
The cellular microenvironment often plays a crucial role in disease development and progression. In recessive dystrophic epidermolysis bullosa (RDEB), biallelic mutations of the gene COL7A1, encoding for collagen VII, the main component of anchoring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc40cf9c40534881a8f2818daaa5272
https://doi.org/10.1007/978-1-4939-9473-1_15
https://doi.org/10.1007/978-1-4939-9473-1_15
Autor:
Kenji Maeda, Adam Cohen Simonsen, Jyoti K. Jaiswal, Stine Lauritzen Sønder, Jesper Nylandsted, Jörn Dengjel, Regine C Tölle, Marja Jäättelä, Theresa Louise Boye
Publikováno v:
Scientific Reports
Sønder, S L, Boye, T L, Tölle, R, Dengjel, J, Maeda, K, Jäättelä, M, Simonsen, A C, Jaiswal, J K & Nylandsted, J 2019, ' Annexin A7 is required for ESCRT III-mediated plasma membrane repair ', Scientific Reports, vol. 9, no. 1, 6726 . https://doi.org/10.1038/s41598-019-43143-4
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Sønder, S L, Boye, T L, Tölle, R, Dengjel, J, Maeda, K, Jäättelä, M, Simonsen, A C, Jaiswal, J K & Nylandsted, J 2019, ' Annexin A7 is required for ESCRT III-mediated plasma membrane repair ', Scientific Reports, vol. 9, no. 1, 6726 . https://doi.org/10.1038/s41598-019-43143-4
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca2+ - and phospholipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e290893812235196179f507708a5e880
https://pubmed.ncbi.nlm.nih.gov/31040365
https://pubmed.ncbi.nlm.nih.gov/31040365
Publikováno v:
Journal of proteome research. 17(8)
In vitro cell culture systems are an invaluable tool for cell biological research to study molecular pathways and to characterize processes critical in human pathophysiology. However, the experimental conditions in two-dimensional (2D) cell cultures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bca326bf4535c0c69da9dd528eedb5c
https://pubmed.ncbi.nlm.nih.gov/29989826
https://pubmed.ncbi.nlm.nih.gov/29989826
Autor:
Kathrin Thedieck, Heike Wiese, Regine C Tölle, Jörn Dengjel, Bettina Warscheid, Mostafa Zarei, Jennifer J. Schwarz
Publikováno v:
Molecular & Cellular Proteomics, 14(8), 2042-2055. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491cfe35e011c2df3dd308c9461df1b6
https://research.rug.nl/en/publications/298a37f9-aa3e-4471-ae98-67f757fcaf19
https://research.rug.nl/en/publications/298a37f9-aa3e-4471-ae98-67f757fcaf19