Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Reginald Davies"'
B2 SINE retrotransposon causes polymorphic expression of mouse 5-aminolevulinic acid synthase 1 gene
Publikováno v:
Biochemical and Biophysical Research Communications. 377:515-520
5-Aminolevulinic acid synthase 1 (ALAS1) is the key enzyme in the homeostasis of nonerythroid heme and of fundamental importance in respiration, the metabolism of drugs, chemicals and steroids and cell signalling. The regulation of ALAS1 in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce8ce9a7afc5cf2902d793984b69386
https://doi.org/10.1016/j.bbrc.2008.10.020
https://doi.org/10.1016/j.bbrc.2008.10.020
Autor:
John Ashby, Helen Tinwell, Nicola Doherty, George Orphanides, Fei Ling Lim, Ian Kimber, Reginald Davies, Andrew G. Smith, Ruth Stuckey, David J. Moore, Jonathan G. Moggs, Tom Aldridge
Publikováno v:
Molecular and Cellular Endocrinology. 253:22-29
We have previously used genome-wide transcript profiling to investigate the relationships between changes in gene expression and physiological alterations during the response of the immature mouse uterus to estrogens. Here we describe the identificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986c9e73be10f09c7a22a0ecb4a5c3db
https://doi.org/10.1016/j.mce.2006.03.031
https://doi.org/10.1016/j.mce.2006.03.031
Autor:
Karl W. Broman, Andrew G. Smith, Bruce Clothier, Gemma R. Grant, Susan W. Robinson, David J. Judah, R.E. Edwards, Reginald Davies
Publikováno v:
Hepatology. 44:174-185
Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5633bd2264428d5a9a75f8877593e27
https://doi.org/10.1002/hep.21233
https://doi.org/10.1002/hep.21233
Autor:
Fiona M. Higginson, Daniel W. Nebert, Peter Greaves, R.E. Edwards, Timothy P. Dalton, Bruce Clothier, Reginald Davies, Andrew G. Smith
Publikováno v:
Biochemical and Biophysical Research Communications. 331:147-152
Aryl hydrocarbon receptor ligands, such as polychlorinated biphenyls (PCBs), cause inhibition of the heme biosynthesis enzyme, uroporphyrinogen decarboxylase; this leads to uroporphyria and hepatic tumors, which are markedly enhanced by iron overload
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb44b2aa880b7c807d00a8c88d78b72e
https://doi.org/10.1016/j.bbrc.2005.03.136
https://doi.org/10.1016/j.bbrc.2005.03.136
Autor:
David J. Judah, David Dinsdale, R.E. Edwards, Bruce Clothier, Andrew G. Smith, Peter Greaves, Reginald Davies, Arenda Schuurman, Colin R. Barker, Fiona M. Higginson, Timothy W. Gant, Tatyana Chernova
Publikováno v:
The American Journal of Pathology. 166:1041-1053
BALB/c Fech(m1Pas) mice have a mutated ferrochelatase gene resulting in protoporphyria that models the hepatic injury occurring sporadically in human erythropoietic protoporphyria. We used this mouse model to study the development of the injury and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cb219fb87c97f2b0537b9b8008bb57
https://doi.org/10.1016/s0002-9440(10)62325-5
https://doi.org/10.1016/s0002-9440(10)62325-5
Publikováno v:
Cancer Letters. 171:27-35
The anti-oestrogenic drug tamoxifen has been under investigation as a breast cancer chemopreventive agent for at least a decade. However, its use for this purpose is still debatable since it is able to induce liver tumours in rats via a mechanism inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a98a8b18d014e0efd7d06e36ecbb33b
https://doi.org/10.1016/s0304-3835(01)00564-x
https://doi.org/10.1016/s0304-3835(01)00564-x
Autor:
Reginald Davies, Karen Brown, Lewis L. Smith, Elizabeth A. Martin, John E. Brown, Philip Carthew, Ian N.H. White, Jerry Styles
Publikováno v:
Carcinogenesis. 22:553-557
It is now generally accepted that activation of tamoxifen occurs as a result of metabolism to alpha-hydroxytamoxifen. In this study, alpha-hydroxytamoxifen was given to female Wistar/Han rats (0.103 or 0.0103 mmol/kg, intraperitoneally, daily for 5 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdb8133357c13db7617ab6a6707291e
https://doi.org/10.1093/carcin/22.4.553
https://doi.org/10.1093/carcin/22.4.553
Autor:
Jerry Styles, Doron Lipson, Andrew G. Smith, Joan Riley, Nicola J. Turton, Reginald Davies, David J. Judah, Timothy W. Gant
Publikováno v:
Oncogene. 20:1300-1306
The multidrug resistance (MDR) phenotype is a major cause of cancer treatment failure. Here the expressions of 4224 genes were analysed for association with intrinsic or acquired doxorubicin (DOX) resistance. A cluster of overexpressed genes related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbc9910423cf6ce28ab29e9b73a8559
https://doi.org/10.1038/sj.onc.1204235
https://doi.org/10.1038/sj.onc.1204235
Publikováno v:
British Journal of Cancer
The MCF-7 doxorubicin-resistant cell line MCF-7/Dox has been used extensively for studies of the multidrug resistance phenomenon. Using fluorescence-activated cell sorting (FACS), these cells were separated into two populations on the basis of rhodam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78b1d52c121b02aa3edf87c38b4cbc8
https://doi.org/10.1038/bjc.1996.54
https://doi.org/10.1038/bjc.1996.54
Publikováno v:
British Journal of Cancer
The potent kinase inhibitor staurosporine and its protein kinase C (PKC)-selective analogue CGP 41251 are known to sensitise cells with the multidrug resistance (MDR) phenotype mediated by P-glycoprotein (P-gp) to cytotoxic agents. Here four PKC-sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0fabd765b57fc6009c793edd4b11bc9
http://europepmc.org/articles/PMC2074394
http://europepmc.org/articles/PMC2074394