Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Reginald, Brys"'
Autor:
Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, Frédéric Labéguère, Christel Menet, Catherine Jagerschmidt, Frenz Ohm, Laszlo Kupcsik, Isabelle Parent, Céline Cottereaux, Florence Marsais, Line Oste, An Van de Water, Thierry Christophe, Steve De Vos, Padraic Fallon, Felix Lauffer, Philippe Clément-Lacroix, Kilian Eyerich, Reginald Brys
Publikováno v:
Science Translational Medicine. 15
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-mediated infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1ddc3b64e21e46fda5864368a152e3
https://doi.org/10.1126/scitranslmed.abj3289
https://doi.org/10.1126/scitranslmed.abj3289
Autor:
K Eyerich, Reginald Brys, Felix Lauffer, Philippe Clément-Lacroix, Padraic Fallon, Catherine Jagerschmidt, Frenz Ohm, Stéphanie Lavazais, Manja Jargosch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4ce05d977b33aebb8a37ce9aebdb3e
https://doi.org/10.26226/m.62fa009c7fa14e00183c0f8f
https://doi.org/10.26226/m.62fa009c7fa14e00183c0f8f
Autor:
Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
Publikováno v:
Journal of Medicinal Chemistry. 63:13526-13545
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272
https://doi.org/10.1021/acs.jmedchem.0c00272
Autor:
Nicolas Triballeau, Bertrand Heckmann, Nicolas Houvenaghel, Tanja Poljak, F. Marsais, Adeline Marie Elise Palisse, Emanuelle Wakselman, Mario Smehil, Mia Jans, Kathleen Sonck, Monica Borgonovi, Denis Bucher, Sandy El Bkassiny, Javier Blanc, Beatrice Coornaert, Thierry Christophe, Philippe Pujuguet, Vatroslav Letfus, M. Auberval, Lola Lecru, Laurent Saniere, Inge Duys, Reginald Brys, Line Oste, Brigitte Allart, Alex Jaunet, Maxim De Wachter, Catherine Jagerschmidt, Koen Karel Jansen, Oscar Mammoliti, Ludovic Waeckel, Giovanni Tricarico, Christel Jeanne Marie Menet, Renata Rupčić
Publikováno v:
Journal of medicinal chemistry. 64(19)
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Current treatments only slow down disease progression, making new therapeutic strategies compelling. Increasing evidence suggests that S1P2 antagonists could be effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045dde34db98ae7f215ad12e45f175db
https://pubmed.ncbi.nlm.nih.gov/34581584
https://pubmed.ncbi.nlm.nih.gov/34581584
Autor:
Thierry Christophe, Nicolas Houvenaghel, Philippe Clément-Lacroix, Reginald Brys, Line Oste, Inge Duys, Emanuelle Wakselman, Bertrand Heckmann, Caroline Joannesse, Alex Jaunet, Adeline Marie Elise Palisse, Brigitte Allart, Laurent Saniere, Mia Jans, Monica Borgonovi, Sandy El Bkassiny, Oscar Mammoliti, Beatrice Coornaert, Christel Jeanne Marie Menet, Kathleen Sonck
Publikováno v:
Journal of medicinal chemistry. 64(9)
Mounting evidence from the literature suggests that blocking S1P2 receptor (S1PR2) signaling could be effective for the treatment of idiopathic pulmonary fibrosis (IPF). However, only a few antagonists have been so far disclosed. A chemical enablemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf77a662664d4953efc380b9590624
https://pubmed.ncbi.nlm.nih.gov/33939425
https://pubmed.ncbi.nlm.nih.gov/33939425
Autor:
Frédéric, Labéguère, Sonia, Dupont, Luke, Alvey, Florilène, Soulas, Gregory, Newsome, Amynata, Tirera, Vanessa, Quenehen, Thi Thu Trang, Mai, Pierre, Deprez, Roland, Blanqué, Line, Oste, Sandrine, Le Tallec, Steve, De Vos, Annick, Hagers, Ann, Vandevelde, Luc, Nelles, Nele, Vandervoort, Katja, Conrath, Thierry, Christophe, Ellen, van der Aar, Emanuelle, Wakselman, Didier, Merciris, Céline, Cottereaux, Cécile, da Costa, Laurent, Saniere, Philippe, Clement-Lacroix, Laura, Jenkins, Graeme, Milligan, Stephen, Fletcher, Reginald, Brys, Romain, Gosmini
Publikováno v:
Journal of medicinal chemistry. 63(22)
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dca817b6050468a00027ab8ce9b149c4
https://pubmed.ncbi.nlm.nih.gov/32902984
https://pubmed.ncbi.nlm.nih.gov/32902984
Publikováno v:
Progress in medicinal chemistry. 59
Aberrant activation of mitogen-activated protein kinases (MAPKs) like c-Jun N-terminal kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human diseases. The apoptosis signal-regulating kinase 1 (ASK1) is an upstream target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40bfa91e57ce6520529dec3eaa9b2ad7
https://pubmed.ncbi.nlm.nih.gov/32362327
https://pubmed.ncbi.nlm.nih.gov/32362327
Autor:
Laurent Saniere, F. Marsais, Steve De Vos, Marlene Kohlhepp, Philippe Pujuguet, Christian Trautwein, Tobias Puengel, Philippe Clément-Lacroix, Tom Luedde, Pavel Strnad, Jana Hundertmark, M. Auberval, Frank Tacke, Reginald Brys, Kenji F. Shoji, Nurdan Guldiken
Publikováno v:
Journal of Clinical Medicine
Journal of Clinical Medicine 9(4), 1140 (2020). doi:10.3390/jcm9041140
Journal of Clinical Medicine, Vol 9, Iss 1140, p 1140 (2020)
Volume 9
Issue 4
Journal of Clinical Medicine 9(4), 1140 (2020). doi:10.3390/jcm9041140
Journal of Clinical Medicine, Vol 9, Iss 1140, p 1140 (2020)
Volume 9
Issue 4
Journal of Clinical Medicine 9(4), 1140 (2020). doi:10.3390/jcm9041140
Published by MDPI, Basel
Published by MDPI, Basel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50671b8322a3091a108efab5f8f1ed6e
http://europepmc.org/articles/PMC7231190
http://europepmc.org/articles/PMC7231190
Aberrant activation of mitogen-activated protein kinases (MAPKs) like c-Jun N-terminal kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human diseases. The apoptosis signal-regulating kinase 1 (ASK1) is an upstream target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f43d1e72e435f3fe5fb1a4690195a2
https://doi.org/10.1016/bs.pmch.2020.02.001
https://doi.org/10.1016/bs.pmch.2020.02.001
Autor:
Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman
Publikováno v:
Journal of Medicinal Chemistry. 60:7371-7392
Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bab957aedfbab6da364d90d0e33f16
https://doi.org/10.1021/acs.jmedchem.7b00647
https://doi.org/10.1021/acs.jmedchem.7b00647