Výsledky vyhledávání - "Regina W Hofland"

Akademický článek

Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q

Autor: Paula Niewold, Douwe J. Dijkstra, Yi Cai, Delia Goletti, Fabrizio Palmieri, Krista E. van Meijgaarden, Frank A. W. Verreck, Onno W. Akkerman, Regina W. Hofland, Eveline M. Delemarre, Stefan Nierkens, Marije K. Verheul, Andrew J. Pollard, Jaap T. van Dissel, Tom H. M. Ottenhoff, Leendert A. Trouw, Simone A. Joosten

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Tuberculosis (TB) is a prevalent disease causing an estimated 1.6 million deaths and 10.6 million new cases annually. Discriminating TB disease from differential diagnoses can be complex, particularly in the field. Increased levels of comple

Externí odkaz: https://doaj.org/article/571b4883ecfe424fa808ac326e39113b

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Akademický článek

Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

Autor: Eveline M. Delemarre, Laura van Hoorn, Aik W. J. Bossink, Julia Drylewicz, Simone A. Joosten, Tom H. M. Ottenhoff, Onno W. Akkerman, Delia Goletti, Elisa Petruccioli, Assunta Navarra, Brigitte T. A. van den Broek, Sanne P. A. Paardekooper, Ineke van Haeften, Leo Koenderman, Jan-Willem J. Lammers, Steven F. T. Thijsen, Regina W. Hofland, Stefan Nierkens

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

IntroductionThere is an urgent medical need to differentiate active tuberculosis (ATB) from latent tuberculosis infection (LTBI) and prevent undertreatment and overtreatment. The aim of this study was to identify biomarker profiles that may support t

Externí odkaz: https://doaj.org/article/32e9ffc238fc4966a4cd5c1d10890db9

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Akademický článek

Whole Blood Mycobacterial Growth Assays for Assessing Human Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis

Autor: Jeroen Bok, Regina W. Hofland, Carlton A. Evans

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundWhole blood mycobacterial growth assays (WBMGA) quantify mycobacterial growth in fresh blood samples and may have potential for assessing tuberculosis vaccines and identifying individuals at risk of tuberculosis. We evaluated the evidence f

Externí odkaz: https://doaj.org/article/785b7805c39740a092709ed4674b8a77

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Clinical effect of lumacaftor/ivacaftor in F508del homozygous CF patients with FEV1 ≥ 90% predicted at baseline

Autor: Harry G.M. Heijerman, S. Schotman, M.M.M. van Oirschot-van de Ven, S. Michel, Bente L. Aalbers, K.M. de Winter-de Groot, Regina W. Hofland, C.K. van der Ent, M.A. Kruijswijk, A.C. de Kiviet, H.G.M. Arets

Publikováno v: Journal of Cystic Fibrosis. 19:654-658

Objective The first available CFTR modulator combination for homozygous F508del patients, lumacaftor/ivacaftor, has not been tested in patients with percentage predicted (pp)FEV1 > 90 in the phase III trials. The objective of this study is to share r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87cab17d005fd0aa550f6058498afa28
https://doi.org/10.1016/j.jcf.2019.12.015

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Females with cystic fibrosis have a larger decrease in sweat chloride in response to lumacaftor/ivacaftor compared to males

Autor: Regina W. Hofland, C.K. van der Ent, S. Schotman, K.M. de Winter-de Groot, Harry G.M. Heijerman, M.A. Kruijswijk, M.M.M. van Oirschot-van de Ven, Bente L. Aalbers, A.C. de Kiviet, H.G.M. Arets, S. Michel, Inez Bronsveld

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 20(1)

Aim To explore which patient-related factors influence sweat test response to CFTR modulators, as well as examining the correlation between the sweat chloride response and ppFEV1 or BMI response, using systematically collected real-life clinical data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e0cafd5c744eccf9ad689a64a3d739
https://pubmed.ncbi.nlm.nih.gov/32448708

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Management of Individual Patient Expectations When Starting with Highly Effective CFTR Modulators

Autor: Harry G.M. Heijerman, Regina W. Hofland, Inez Bronsveld, Bente L. Aalbers

Publikováno v: Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 811, p 811 (2021)

Highly effective CFTR modulators such as elexacaftor/tezacaftor/ivacaftor (ELE/TEZ/IVA will become available for an increasing number of people with cystic fibrosis (pwCF) in the near future. Before the start of this therapy, many questions may arise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadedf2e619d1a0bbcc298b823edd035
https://doi.org/10.3390/jpm11080811

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Melioidosis in travelers : An analysis of Dutch melioidosis registry data 1985–2018

Publikováno v: Travel Medicine and Infectious Disease, 32. Elsevier USA
Travel Medicine and Infectious Disease, 32
Tropical medicine and infectious disease, 32:101461. Elsevier Inc.
Travel medicine and infectious disease, 32:101461. Elsevier USA

Background: Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an opportunistic infection across the tropics. Here, we provide a systematic overview of imported human cases in a non-endemic country over a 25-year period.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d253ea96be7bc15ca3ff611ebb0e23
https://dspace.library.uu.nl/handle/1874/389254

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