HBO1 is required for the maintenance of leukaemia stem cells

Autor: Melanie de Silva, Stewart D. Nuttall, Chen Fang Weng, Bin Ren, Paul Stupple, Mark A. Dawson, Annabelle Hoegl, Tim Thomas, Kathy Knezevic, Ian P. Street, George S. Vassiliou, Catalina Carrasco-Pozo, Yuqing Yang, Marnie E. Blewitt, Tracy A. Willson, Christopher J. Burns, Kah Lok Chan, Juliana Anokye, Linden J. Gearing, Thomas S. Peat, Janet Newman, Olan Dolezal, Oliver M. Dovey, Regina Surjadi, Miriam S. Butler, Laura MacPherson, Paul Yeh, Vicky M. Avery, Jonathan B. Baell, Enid Y.N. Lam, Yuxin Sun, Anne K. Voss, Nghi H. Nguyen, Ming Zhang, Matthew L. Dennis, Hendrik Falk, Rebecca A. Bilardi, Poh Sim Khoo, Marian L. Burr, Brendon J. Monahan, Miriam M. Yeung, Jarny Choi, Yih-Chih Chan, Chunaram Choudhary, Florian Grebien, Sarah-Jane Dawson, Joy Liu, David J. Leaver

Publikováno v: MacPherson, L, Anokye, J, Yeung, M M, Lam, E Y N, Chan, Y-C, Weng, C-F, Yeh, P, Knezevic, K, Butler, M S, Hoegl, A, Chan, K-L, Burr, M L, Gearing, L J, Willson, T, Liu, J, Choi, J, Yang, Y, Bilardi, R A, Falk, H, Nghi Nguyen, Stupple, P A, Peat, T S, Zhang, M, De Silva, M, Carrasco-Pozo, C, Avery, V M, Khoo, S, Dolezal, O, Dennis, M L, Nuttall, S, Surjadi, R, Newman, J, Ren, B, Leaver, D J, Sun, Y, Baell, J B, Dovey, O, Vassiliou, G S, Grebien, F, Dawson, S-J, Street, I P, Monahan, B J, Burns, C J, Choudhary, C, Blewitt, M E, Voss, A K, Thomas, T & Dawson, M A 2020, ' HBO1 is required for the maintenance of leukaemia stem cells ', Nature, vol. 577, no. 7789, pp. 266-270 . https://doi.org/10.1038/s41586-019-1835-6

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3bc6f449feaabadd1fab4f6f8e7cdc

Enzyme synthesis and activity assay in microfluidic droplets on a chip

Autor: Chris Abell, John G. Oakeshott, Regina Surjadi, Nan Wu, Fabienne Courtois, Yonggang Zhu, Christopher J. Easton, Thomas S. Peat

Publikováno v: Engineering in Life Sciences. 11:157-164

There is growing demand for high-throughput measurement of biochemical reactions in drug discovery and directed evolution programs. To meet this need, a powerful platform based on droplet-based bioreactors manipulated by microfluidic systems is being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7c28dd86d31286eb6a013820ba34dc1
https://doi.org/10.1002/elsc.201000043

Determination of the structure of the catabolic N-succinylornithine transaminase (AstC) from Escherichia coli

Autor: Charlotte C. Williams, Janet Newman, Del Lucent, Matthew Wilding, Thomas S. Peat, Colin Scott, Regina Surjadi, Shane A. Seabrook

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58298 (2013)
PLoS ONE

Escherichia coli possesses two acyl ornithine aminotransferases, one catabolic (AstC) and the other anabolic (ArgD), that participate in L-arginine metabolism. Although only 58% identical, the enzymes have been shown to be functionally interchangeabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ffb80bdf523167e389e31ac124596
http://europepmc.org/articles/PMC3590144?pdf=render

A double-emulsion microfluidic platform forin vitrogreen fluorescent protein expression

Autor: Yonggang Zhu, John G. Oakeshott, Thomas S. Peat, Regina Surjadi, Christopher D. Easton, Nan Wu

Publikováno v: Journal of Micromechanics and Microengineering. 21:054032

Microfluidic droplet technology has gained popularity due to the advantages over conventional emulsion techniques and capabilities for a wide range of applications. In this paper, the development of a simple microfluidic-based double-emulsion system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7354e1988f90f54235c98c25578eeecd
https://doi.org/10.1088/0960-1317/21/5/054032