Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Regina Stöber"'
1
Enhanced activation of human NK cells by drug-exposed hepatocytes
Autor: Regina Stöber, Jan G. Hengstler, Carsten Watzl, Martin Obholzer, Frank Fasbender, Sarah Metzler
Publikováno v: Archives of toxicology, 94:439-48
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new interaction between drug-exposed hepatocytes and natural killer (NK) cells. In a previous genome-wide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcf9b8ac39eb6e97b3d86c684f4f946
https://doi.org/10.1007/s00204-020-02668-8
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2
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
Autor: Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
Publikováno v: Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461
Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is presented. It details all proce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e81d40cbe9c93d9b654557d3afcabe
https://hdl.handle.net/1887/3184413
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5
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors
Autor: Nina V. Balmer, Julia Liebing, Regina Stöber, Marianna Grinberg, Stefan Schildknecht, Lisa Hoelting, Vaibhav Shinde, Eugen Rempel, Nils Blüthgen, Marcel Leist, Tanja Waldmann, Christoph van Thriel, John Antonydas Gaspar, Agapios Sachinidis, Jan G. Hengstler, Rosemarie Marchan, Jörg Rahnenführer, Johannes Meisig
Publikováno v: Archives of toxicology, 89(9): 1599–1618
Archives of Toxicology
Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ffebe4abc3c7643174833bb49c1c8c
https://doi.org/10.1007/s00204-015-1573-y
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7
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
Autor: Markus Schug, Regina Stöber, Tanja Heise, Hans Mielke, Ursula Gundert-Remy, Patricio Godoy, Raymond Reif, Meinolf Blaszkewicz, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Silvia Selinski, Georgia Günther, Rosemarie Marchan, Agapios Sachinidis, Andreas Nüssler, Axel Oberemm, Jan G. Hengstler
Publikováno v: Archives of Toxicology; Vol 87
Archives of Toxicology
Cultivated hepatocytes represent a well-established in vitro system. However, the applicability of hepatocytes in toxicogenomics is still controversially discussed. Recently, an in vivo/in vitro discrepancy has been described, whereby the non-genotox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e718a8d8ed9e8fbbb9075473c977a4d
https://doi.org/10.1007/s00204-012-0999-8
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9
A novel oxygenase from Pleurotus sapidus transforms valencene to nootkatone
Autor: Manfred Nimtz, Stephanie Johanna Luise Riemer, Holger Zorn, Marco A. Fraatz, Ralf G. Berger, Regina Stöber, Rüdiger Kaspera
Publikováno v: Journal of Molecular Catalysis B: Enzymatic. 61:202-207
A selective and highly efficient allylic oxidation of the sesquiterpene (+)-valencene to (+)-nootkatone was achieved with lyophilisate of the basidiomycete Pleurotus sapidus . The responsible enzymatic activity was biochemically characterised and pur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60552a8e8ccb8940730de63f35cf9044
https://doi.org/10.1016/j.molcatb.2009.07.001
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10
Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis
Autor: Maria de Lourdes Bastos, Marcelo Dutra Arbo, Jörg Rahnenführer, Patricio Godoy, Markus Schug, Helena Carmo, Regina Stöber, Simone Melega, Cristina Cadenas, Eugen Rempel, Raymond Reif, Jan G. Hengstler
Publikováno v: Archives of toxicology. 90(12)
The piperazine derivatives most frequently consumed for recreational purposes are 1-benzylpiperazine, 1-(3,4-methylenedioxybenzyl) piperazine, 1-(3-trifluoromethylphenyl) piperazine and 1-(4-methoxyphenyl) piperazine. Generally, they are consumed as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758e53b3906e93a01b9827d12be2985a
https://pubmed.ncbi.nlm.nih.gov/26821219
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