Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Regina Resta"'
Autor:
Pashtoon Murtaza Kasi, Sakti Chakrabarti, Leslie Bucheit, Jason Scott Starr, Racquel Innis-Shelton, Ardaman Shergill, Hiba Dada, Regina Resta, Stephanie Wagner, Naomi Fei
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/605590a30d7b4c05973e28dd694297b5
Autor:
Sakti Chakrabarti, Leslie Bucheit, Jason Scott Starr, Racquel Innis-Shelton, Ardaman Shergill, Hiba Dada, Regina Resta, Stephanie Wagner, Naomi Fei, Pashtoon Murtaza Kasi
Publikováno v:
Journal for immunotherapy of cancer. 10(6)
Clinical trials reporting the robust antitumor activity of immune checkpoint inhibitors (ICIs) in microsatellite instability-high (MSI-H) solid tumors have used tissue-based testing to determine the MSI-H status. This study assessed if MSI-H detected
Autor:
Sakti Chakrabarti, Leslie A. Bucheit, Jason S. Starr, Racquel Innis-Shelton, Ardaman Shergill, Regina Resta, Stephanie Ann Wagner, Pashtoon Murtaza Kasi
Publikováno v:
Journal of Clinical Oncology. 40:607-607
607 Background: Immunotherapy (IO) is known to have robust anti-tumor activity in patients with MSI-H solid tumors. However, clinical trials investigating IO activity have used tissue-based testing to determine MSI-H status. Pancreatic tumor biopsy o
Autor:
Yunfei Wang, Beth A. Hellerstedt, Steven Papish, Lina Asmar, Frankie A. Holmes, Joyce O'Shaughnessy, Shrinivas M. Diggikar, Praveen K. Reddy, Regina Resta, Susan Peck, Lea Krekow, Patricia S. Fox, Rufus P. Collea, Svetislava J. Vukelja
Publikováno v:
Journal of Clinical Oncology. 34:1594-1600
Purpose This prospective study assessed the impact of 2 years of aromatase inhibitor (AI) therapy on the incidence of ovarian function recovery (OFR) in women age 40 to 49 with estrogen receptor–positive breast cancer who were premenopausal at diag
Autor:
Yoshio Yamashita, Paul W. Kincade, Regina Resta, Scott W. Hooker, Linda F. Thompson, Andrew J. Coe, Aletha B. Laurent, Kamayani Khare, Hong Jiang
Publikováno v:
European Journal of Immunology. 28:2981-2990
CD73 is a glycosyl phosphatidylinositol-anchored protein with both ecto-enzyme activity (ecto-5'-nucleotidase) and signal transducing capabilities for human T lymphocytes. We now report an analysis of the distribution and function of CD73 in murine l
Publikováno v:
Immunological Reviews. 161:95-109
CD73 or ecto-5'-nucleotidase (5'-NT) is a widely expressed ecto-enzyme which catalyzes the dephosphorylation of AMP and other nucleoside monophosphates. CD73 participates in purine salvage through this enzymatic activity, supplying cells with precurs
Autor:
Kent L. Buchanan, Glennda Smithson, Elizabeth A. Smith, Regina Resta, Carol F. Webb, Shenshen Dou
Publikováno v:
Molecular Immunology. 34:743-750
While expression of functional heavy chain immunoglobulin mRNA requires rearrangement of variable (V H ), diversity (D) and (JH) gene segments, these individual gene segments can be transcribed prior to their rearrangement. It has been proposed that
Autor:
N L Nadon, S. M. Jamshedur Rahman, M Franklin, Regina Resta, Thomas B. Knudsen, Scott W. Hooker, Linda F. Thompson, Aletha B. Laurent
Publikováno v:
Journal of Clinical Investigation. 99:676-683
The adenosine producing enzyme ecto-5'-nucleotidase (5'-NT) is not normally expressed during thymocyte development until the medullary stage. To determine whether earlier expression would lead to adenosine accumulation and/or be deleterious for thymo
Autor:
Linda F. Thompson, Regina Resta
Publikováno v:
Cellular Signalling. 9:131-139
CD73 (ecto-5′-nucleotidase), a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes, catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates
Publikováno v:
Cellular Immunology. 161:213-217
It had previously been shown that CD73 (ecto-5'-nucleotidase) expressed on 30% of normal human peripheral T-lymphocytes can mediate costimulatory signals in T cell activation. To check for a possible contribution of the catalytic property of CD73 to