Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Regina Osiecka"'
Autor:
Dolf Evenberg, Karim Bahmed, Sunny A. Anuels, Beata Kosmider, Regina Osiecka, Justyn Ochocki, Elzbieta Zyner
Publikováno v:
Arzneimittelforschung. 60:149-156
cis-DDP (cis-diamminedichloroplatinu-m(II), CAS 15663-27-1) is widely used in chemotherapy of many types of cancer. However, besides effectiveness, it gives many side effects which limit its clinical application. Therefore, nowadays studies are focus
Autor:
Justyn Ochocki, Regina Osiecka, Urszula Kalinowska-Lis, Katarzyna Eliza (Kate) Rainczuk, Ksenia Matlawska-Wasowska
Publikováno v:
Chemico-Biological Interactions. 168:135-142
The dynamic development of metal-containing anticancer drugs has started since the discovery of cis -diamminedichloroplatinum(II). For many years it was believed that trans platinum(II) compounds were non-active as antitumour agents because trans -di
Autor:
Elzbieta Zyner, Regina Osiecka, Izabela Zawlik, Justyn Ochocki, Jacek Bartkowiak, Pawel P. Liberski, Beata Kosmider
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 604:28-35
Currently cis-diamminedichloroplatinum(II) (cis-DDP) is one of the most commonly applied compounds in chemotherapy of many types of cancer. However, a drawback is that its effectiveness presents with many side effects. Therefore, human normal lymphoc
Autor:
Justyn Ochocki, Urszula Kalinowska, Lilianna Chęcińska, Małgorzata Domagała, Renata Kontek, Ksenia Matlawska, Regina Osiecka
Publikováno v:
Journal of Inorganic Biochemistry. 99:2024-2031
Preparations of cis- and trans-platinum(II) complexes of diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe) have been described. These complexes were identified and characterized by far-IR, 1H NMR, 13C NMR, 31P NMR and 195Pt NMR and microanalyses. The c
Autor:
Elzbieta Zyner, Regina Osiecka, Izabela Wojcik, Justyn Ochocki, Pawel P. Liberski, Jacek Bartkowiak, Beata Kosmider
Publikováno v:
Investigational New Drugs. 23:287-297
Lung cancer remains one of the most common causes of cancer-related death worldwide. Approximately 80% is histologically non-small cell lung carcinoma (NSCLC) and in about 70% of patients it is an unresectable type. Clinical studies indicated that ap
Publikováno v:
European Journal of Inorganic Chemistry. 2005:3109-3117
The aim of many studies is to discover new chemicals as potential antitumor agents. We have prepared novel analogues of 5-fluorouracil (5-Fu): 5-uracilmethylphosphonic acid (5umpa), dimethyl 5-uracilmethylphosphonate (5-umpm), diethyl 5-uracilmethylp
Publikováno v:
Drug and Chemical Toxicology. 28:231-244
cis-bis(3-aminoflavone)dichloroplatinum(II) [cis-Pt(II) complex of 3-aminoflavone] is an analog of cis-DDP characterized by low cytotoxicity and anticancer properties in vivo. In order to evaluate genotoxic properties of this chemical compound, the c
Autor:
Regina Osiecka, Beata Kosmider
Publikováno v:
Drug Development Research. 63:200-211
Flavonoid compounds, especially quercetin and genistein, have antitumor activity. These compounds are cytotoxic to cancer cells but have no or insignificant activity in normal cells. These beneficial properties prompted synthesis of flavonoid synthet
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 563:61-70
Non-small cell lung cancer (NSCLC) includes a group of tumors that respond poorly to drugs. cis-Diamminedichloroplatinum(II) (cis-DDP) toxicity still remains problematic, and not completely solved by the improvement of supportive care. Therefore, the
Autor:
Justyn Ochocki, Leszek Szmigiero, Regina Osiecka, Elzbieta Zyner, Ewa Ciesielska, Beata Kosmider
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 558:169-179
cis-Diamminedichloroplatinum(II) (cis-DDP) is one of the most widely administrated antitumor drugs. However, the use of cis-DDP is severely limited because of its toxic side effects. Therefore, efforts are concentrated on the development of improved