Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Regina Mirgayazova"'
Autor:
Raniya Khadiullina, Regina Mirgayazova, Damir Davletshin, Elvina Khusainova, Vitaly Chasov, Emil Bulatov
Publikováno v:
Life, Vol 13, Iss 1, p 31 (2022)
The p53 protein is a transcription factor that preserves the integrity of the genome. The TP53 gene has inactivating mutations in about 50% of all human cancers. Some missense mutations lead to decreased thermal stability in the p53 protein, its unfo
Externí odkaz:
https://doaj.org/article/04499f76dc52404cae4f9ab0b9ebbdd9
Autor:
Georgiy Korenev, Sergey Yakukhnov, Anastasia Druk, Anastasia Golovina, Vitaly Chasov, Regina Mirgayazova, Roman Ivanov, Emil Bulatov
Publikováno v:
Cancers, Vol 14, Iss 22, p 5539 (2022)
Ubiquitin-specific protease 7 (USP7) regulates the stability of a plethora of intracellular proteins involved in the suppression of anti-tumor immune responses and its overexpression is associated with poor survival in many cancers. USP7 impairs the
Externí odkaz:
https://doaj.org/article/3adfe8a3b9d34eddb790197f77a115ac
Autor:
Vitaly Chasov, Mikhail Zaripov, Regina Mirgayazova, Raniya Khadiullina, Ekaterina Zmievskaya, Irina Ganeeva, Aigul Valiullina, Albert Rizvanov, Emil Bulatov
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Transcription factor and oncosuppressor protein p53 is considered as one of the most promising molecular targets that remains a high-hanging fruit in cancer therapy. TP53 gene encoding the p53 protein is known to be the most frequently mutated gene i
Externí odkaz:
https://doaj.org/article/015ab42fba0640eaaca97c4a71907b72
Autor:
Vitaly Chasov, Regina Mirgayazova, Ekaterina Zmievskaya, Raniya Khadiullina, Aygul Valiullina, Joseph Stephenson Clarke, Albert Rizvanov, Matthias G. J. Baud, Emil Bulatov
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The transcription factor p53 is a key tumor suppressor that is inactivated in almost all cancers due to either point mutations in the TP53 gene or overexpression of its negative regulators. The p53 protein is known as the “cellular gatekeeper” fo
Externí odkaz:
https://doaj.org/article/bd5dac044856409a9eb9ccd1aa8db9b8
Autor:
Regina Mirgayazova, Raniya Khadiullina, Vitaly Chasov, Rimma Mingaleeva, Regina Miftakhova, Albert Rizvanov, Emil Bulatov
Publikováno v:
Genes, Vol 11, Iss 6, p 704 (2020)
The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence. In many cases, alterations (e.g.
Externí odkaz:
https://doaj.org/article/6d53e6899b884bc88087d5d02a3e7b41
Granulocyte-Macrophage Colony-Stimulating Factor and CAR-T Technology for Solid Tumors in Experiment
Autor:
Regina Mirgayazova, Daniil Zaytsev, Emil Bulatov, A.S. Golovkin, A.V. Petukhov, A.Kh. Valiullina, A.Yu. Zaritskey, Alexandra Daks, Ekaterina Zaikova
Publikováno v:
Kliničeskaâ onkogematologiâ, Vol 13, Iss 2, Pp 115-122 (2019)
Background. Cytokines are considered as important factors that enhance the efficacy of CAR-T cell therapy. Besides, they are key elements of the pathogenesis of cytokine release syndrome and neurotoxicity in applying the CAR-T technology. However, cy
Autor:
Mikhail M. Zaripov, Albert A. Rizvanov, Regina Mirgayazova, Emil Bulatov, Ekaterina Zmievskaya, Raniya Khadiullina, Irina Ganeeva, V. V. Chasov, Aigul Valiullina
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Transcription factor and oncosuppressor protein p53 is considered as one of the most promising molecular targets that remains a high-hanging fruit in cancer therapy. TP53 gene encoding the p53 protein is known to be the most frequently mutated gene i
Autor:
Regina Mirgayazova, Joseph Richard Stephenson Clarke, Albert A. Rizvanov, V. V. Chasov, Emil Bulatov, Aygul Valiullina, Matthias G. J. Baud, Raniya Khadiullina, Ekaterina Zmievskaya
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
The transcription factor p53 is a key tumor suppressor that is inactivated in almost all cancers due to either point mutations in the TP53 gene or overexpression of its negative regulators. The p53 protein is known as the “cellular gatekeeper” fo
Autor:
Emil Bulatov, Regina R. Miftakhova, V. V. Chasov, Albert A. Rizvanov, Rimma N. Mingaleeva, Raniya Khadiullina, Regina Mirgayazova
Publikováno v:
Genes, Vol 11, Iss 704, p 704 (2020)
Genes
Genes
The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence. In many cases, alterations (e.g.