Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Regina M. Murphy"'
Autor:
Kartik Gupta, Kyle A. Brown, Marvin L. Hsieh, Brandon M. Hoover, Jianxin Wang, Mitri K. Khoury, Vijaya Satish Sekhar Pilli, Reagan S. H. Beyer, Nihal R. Voruganti, Sahil Chaudhary, David S. Roberts, Regina M. Murphy, Seungpyo Hong, Ying Ge, Bo Liu
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 9, Pp n/a-n/a (2022)
Abstract Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and
Externí odkaz:
https://doaj.org/article/1611aac2dc7f44d6ac3e4aebb543df92
Autor:
Chandler B Est, Regina M Murphy
Publikováno v:
eLife, Vol 12 (2023)
Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent ste
Externí odkaz:
https://doaj.org/article/57915705e2544eda8b9df6573933fbac
Autor:
Isabel U. Foreman-Ortiz, Ting Fung Ma, Brandon M. Hoover, Meng Wu, Catherine J. Murphy, Regina M. Murphy, Joel A. Pedersen
Publikováno v:
Journal of Colloid and Interface Science. 615:50-58
Nanoparticle tracking analysis (NTA) is a single particle tracking technique that in principle provides a more direct measure of particle size distribution compared to dynamic light scattering (DLS). Here, we demonstrate how statistical mixture distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6757485bbba7bd39a6722704c56f9b5b
https://doi.org/10.1016/j.jcis.2022.01.141
https://doi.org/10.1016/j.jcis.2022.01.141
Autor:
Chandler B. Est, Regina M. Murphy
Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood-brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b60e30f565723d797d007a0a20fa9f8b
https://doi.org/10.1101/2023.04.11.536348
https://doi.org/10.1101/2023.04.11.536348
Autor:
Brandon M. Hoover, Regina M. Murphy
Publikováno v:
Journal of Pharmaceutical Sciences. 109:452-463
Nanoparticle tracking analysis (NTA) is an important technique for measuring hydrodynamic size of globular biological particles including liposomes and viruses. Less attention has been paid to NTA of rod-like particles, despite their considerable int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc42e6e67a05c31bc38a43b06c8e641f
https://doi.org/10.1016/j.xphs.2019.10.006
https://doi.org/10.1016/j.xphs.2019.10.006
Autor:
Reid C. Van Lehn, Regina M. Murphy, Curran G Gahan, Brandon M. Hoover, Zhizhang Shen, David M. Lynn
Publikováno v:
The journal of physical chemistry. B. 125(6)
α-Synuclein is an intrinsically disordered protein abundant in presynaptic terminals in neurons and in synaptic vesicles. α-Synuclein's interaction with lipid bilayers is important not only for its normal physiological function but also in its path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a65f9e35f4260492b089dfd6b41f1d
https://pubmed.ncbi.nlm.nih.gov/33538595
https://pubmed.ncbi.nlm.nih.gov/33538595
Autor:
Parth Mangrolia, Regina M. Murphy
Publikováno v:
Biochemistry. 57:5029-5040
β-Amyloid (Aβ) aggregation is causally linked to Alzheimer’s disease. On the basis of in vitro and transgenic animal studies, transthyretin (TTR) is hypothesized to provide neuroprotection against Aβ toxicity by binding to Aβ and inhibiting its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864a7ec0fa13db5d3f312fcac634d1c9
https://doi.org/10.1021/acs.biochem.8b00517
https://doi.org/10.1021/acs.biochem.8b00517
Publikováno v:
ChemMedChem. 13:968-979
β-Amyloid (Aβ) aggregation is causally linked to neuronal pathology in Alzheimer's disease; therefore, several small molecules, antibodies, and peptides have been tested as anti-Aβ agents. We developed two compounds based on the Aβ-binding domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4858697eee3410236b5e59455dc44c32
https://doi.org/10.1002/cmdc.201800031
https://doi.org/10.1002/cmdc.201800031
Autor:
Regina M. Murphy, Tyler J. Perlenfein
Publikováno v:
Journal of Biological Chemistry. 292:21071-21082
β-Amyloid (Aβ) aggregation is thought to initiate a cascade of neurodegenerative events in Alzheimer's disease (AD). Much effort is underway to develop strategies to reduce Aβ concentration or inhibit aggregation. Cathepsin B (CatB) proteolyticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55e9d8abc53e6eb13efdb5eab841005
https://doi.org/10.1074/jbc.m117.811448
https://doi.org/10.1074/jbc.m117.811448
Publikováno v:
Journal of Biological Chemistry. 292:11485-11498
Cystatin C (CysC) is a versatile and ubiquitously-expressed member of the cysteine protease inhibitor family that is present at notably high concentrations in cerebrospinal fluid. Under mildly denaturing conditions, CysC forms inactive domain-swapped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e164c17544323cf5bbf2a8333e1cb8a6
https://doi.org/10.1074/jbc.m117.786558
https://doi.org/10.1074/jbc.m117.786558