Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Regina M. Carelli"'
Publikováno v:
Addiction Neuroscience, Vol 7, Iss , Pp 100097- (2023)
Substance use disorders (SUDs) are characterized by maladaptive signaling in the prefrontal cortex and associated regions, however precisely how these drug-induced abnormalities may be linked to drug seeking/taking behaviors is not well understood. H
Externí odkaz:
https://doaj.org/article/6756ebbda7cc4545bdfb97187b0353e4
Publikováno v:
The Journal of Neuroscience. 43:647-655
Distress tolerance (DT) is defined as the ability to persist in challenging goal-directed behavior in the face of stress, and individuals with low DT exhibit heightened drug-seeking behavior. However, no preclinical studies have examined the neurobio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a65ea671e761d0239bc0c9ab0b3a3eff
https://doi.org/10.1523/jneurosci.1718-22.2022
https://doi.org/10.1523/jneurosci.1718-22.2022
Autor:
Regina M. Carelli, Travis M. Moschak
Publikováno v:
Drug Alcohol Depend
Background Both drug and natural reward-seeking have been shown to increase following an extended period of abstinence, a phenomenon termed ‘incubation of craving’. Although this phenomenon involves many brain regions, the projections from the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972e2f1811c9ac7cea62ff6d61482849
https://europepmc.org/articles/PMC8595637/
https://europepmc.org/articles/PMC8595637/
Publikováno v:
The Journal of Neuroscience. 39:3108-3118
In delay discounting, individuals discount the value of a reward based on the delay to its receipt. The prelimbic cortex (PrL) is heavily interconnected with several brain regions implicated in delay discounting, but the specific contributions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a491df695771f1927b4275f8cafdb9fd
https://doi.org/10.1523/jneurosci.2532-18.2019
https://doi.org/10.1523/jneurosci.2532-18.2019
Autor:
Travis M. Moschak, Regina M. Carelli
Publikováno v:
Neuropsychopharmacology
Although impulsive action is strongly associated with addiction, the neural underpinnings of this relationship and how they are influenced by sex have not been well characterized. Here, we used a titrating reaction time task to assess differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0815f9679915a43ee9c62524c668e4b9
https://europepmc.org/articles/PMC8280154/
https://europepmc.org/articles/PMC8280154/
Autor:
Regina M. Carelli, Mark Niedringhaus, Heather K. Ortega, Rachel M. Haake, Flavio Fröhlich, Elizabeth A. West
Publikováno v:
Biol Psychiatry
Background To obtain desirable goals, individuals must predict the outcome of specific choices, use that information to direct appropriate actions, and adjust behavior accordingly in changing environments (behavioral flexibility). Substance use disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8e64f1bec2d1ad2486d0c7a97652be
https://europepmc.org/articles/PMC8106639/
https://europepmc.org/articles/PMC8106639/
Publikováno v:
The Journal of Neuroscience. 38:8463-8472
In substance use disorders, negative affect associated with drug withdrawal can elicit strong drug craving and promote relapse. One brain region implicated in those processes is the rostral agranular insular cortex (RAIC), although precisely how this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81a4a5d4b7dfa01c07e064453a2bc62
https://doi.org/10.1523/jneurosci.1195-18.2018
https://doi.org/10.1523/jneurosci.1195-18.2018
Publikováno v:
Biological Psychiatry. 82:839-846
Background Negative reinforcement theories of drug addiction posit that addicts use drugs to alleviate negative mood states. In a preclinical model developed in our laboratory, rats exhibit negative affect to a normally rewarding taste cue when it pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b6698ba2743541ec0c9dbeb6c1732a
https://doi.org/10.1016/j.biopsych.2017.05.009
https://doi.org/10.1016/j.biopsych.2017.05.009
Autor:
Regina M. Carelli, Seth W. Hurley
Publikováno v:
J Neurosci
Hedonic processing plays an integral role in directing appropriate behavior, but disrupted hedonic processing is associated with psychiatric disorders such as depression. The infralimbic cortex (IL) is a key structure in affective processing in roden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a45175c51f63f63585a9b7e12a62dac
https://pubmed.ncbi.nlm.nih.gov/32727819
https://pubmed.ncbi.nlm.nih.gov/32727819
Publikováno v:
Eur J Neurosci
Effective decision-making depends on an animal’s ability to predict and select the outcome of greatest value, and the nucleus accumbens (NAc) and its dopaminergic input play a key role in this process. We previously reported that rapid dopamine rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3f8601ebfb618d2e6c791043999615
https://europepmc.org/articles/PMC8234437/
https://europepmc.org/articles/PMC8234437/