Výsledky vyhledávání - "Regina Graul"

Akademický článek

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi

Externí odkaz: https://doaj.org/article/e994be112c3a40db87031271143e9556

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Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease

Autor: Regina Graul, Jaime L. Masferrer, Huihui Li, Sylvie G. Bernier, Paul S. Frenette, Raghunath Ramanarasimhaiah, Juli E. Jones, Xin Gao, Boris Tchernychev, Robert Feil, Guang Liu, Emmanuel S. Buys, Katherine C. Hall, Susanne Feil, Sung Kyun Lee

Publikováno v: British Journal of Pharmacology

Background and purpose Reduced nitric oxide (NO) bioavailability, a hallmark of sickle cell disease (SCD), contributes to intravascular inflammation, vasoconstriction, vaso-occlusion, and organ damage observed in SCD patients. Soluble guanylyl cyclas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea283f89e5e81d139c3fe1dd9b2b087
https://pubmed.ncbi.nlm.nih.gov/33864386

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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235faf214a0dad4f1fdd0e1ad72b1cd8
https://pubmed.ncbi.nlm.nih.gov/32322204

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Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

Autor: Regina Graul, Jennifer G. Chickering, Daniel P. Zimmer, Yueh-Tyng Chien, George Todd Milne, Jaime L. Masferrer, John R. Hadcock, Emmanuel S. Buys, Albert T. Profy

Publikováno v: Nitric Oxide. 78:72-80

Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophophate (cGMP), transduces many of the physiological effects of the gasotransmitter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b94683b3d8f60510c8bfee0cfce67b6
https://doi.org/10.1016/j.niox.2018.05.009

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The Effect of the Soluble Guanylate Cyclase Stimulator Olinciguat on Renal Function and Biomarkers of Inflammation and Renal Injury in Sickle Cell Mice

Autor: Guang Liu, Regina Graul, Boris Tchernychev, Jaime L. Masferrer, Raghunath Ramanarasimhaiah, Katherine S. Hall

Publikováno v: Blood. 134:3554-3554

Introduction: Nephropathy, one of the most common complications of sickle cell disease (SCD), shortens life expectancy and accounts for 16-18% of SCD-associated deaths. SCD nephropathy is caused by recurrent vaso-occlusions (Am. J. Hematol. 2014;89:9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4ee1597cb7239074fa72506c8748797
https://doi.org/10.1182/blood-2019-127361

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The Effect of the Soluble Guanylyl Cyclase Stimulator Olinciguat on ƴ-Globin Gene Induction in K562 Cells

Autor: Boris Tchernychev, Jaime L. Masferrer, Regina Graul, Asha Pant, Todd G Milne, Mark G. Currie, Joy Miyashiro

Publikováno v: Blood. 132:1078-1078

Induction of fetal hemoglobin (HbF: α2ƴ2) is a recognized mode of action of hydroxyurea, the sickle cell disease (SCD) standard of care in SCD, and has been shown to prevent red blood cell (RBC) sickling. Discovery of novel HbF inducers is underway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93cd5215422c8858c38177619ed87e23
https://doi.org/10.1182/blood-2018-99-116011

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