Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Regina Goetz"'
Autor:
Martina Barthold, Anne Jurkutat, Regina Goetz, Lucia Schubring, Juliane Spiegler, Ann-Sophie Fries, Lucia Kiesel, Joerg Klepper
Publikováno v:
Children, Vol 10, Iss 4, p 681 (2023)
The aim of this research was to characterize cognitive abilities in patients with Glut1-Deficiency syndrome (Glut1DS) following ketogenic diet therapy (KDT). Methods: The cognitive profiles of eight children were assessed using the Wechsler Intellige
Externí odkaz:
https://doaj.org/article/f5abeb1ccaa14aefb67ad0fa4d99cf7d
Autor:
Hannes Olauson, Karolina Lindberg, Risul Amin, Tadatoshi Sato, Ting Jia, Regina Goetz, Moosa Mohammadi, Göran Andersson, Beate Lanske, Tobias E Larsson
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003975 (2013)
Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in renal secondary hyperparathyroidism. To dissect the role of parathy
Externí odkaz:
https://doaj.org/article/c03e0589a7364e2d9a3ea05f66081ee1
Autor:
Karolina Lindberg, Hannes Olauson, Risul Amin, Arvind Ponnusamy, Regina Goetz, Rebecca F Taylor, Moosa Mohammadi, Ann Canfield, Karolina Kublickiene, Tobias E Larsson
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60658 (2013)
Recent studies support a role for FGF23 and its co-receptor Klotho in cardiovascular pathology, yet the underlying mechanisms remain largely elusive. Herein, we analyzed the expression of Klotho in mouse arteries and generated a novel mouse model har
Externí odkaz:
https://doaj.org/article/2c3e4060d78a46f98c1066ca1813ecc6
Autor:
Farah Al Sabie, Justine Bacchetta, Vincent Brandenburg, Ming Chang Hu, Chang Huei Chen, Lingfeng Chen, Erica L. Clinkenbeard, Michael J. Econs, Daniela Egli-Spichtig, Reinhold G. Erben, Sarah Erem, Carlos C. Faraco, Seiji Fukumoto, Regina Goetz, Alexander Grabner, Dieter Haffner, Mark R. Hanudel, Ping He, Gunnar H. Heine, Martin Hewison, Jan-Luuk Hillebrands, Keith A. Hruska, Chou-Long Huang, Erik A. Imel, Anna Jovanovich, Stefanie Krick, Makoto Kuro-o, Seong Min Lee, Maren Leifheit-Nestler, Rik Mencke, Orson W. Moe, Moosa Mohammadi, John Musgrove, Javier A. Neyra, Hannes Olauson, Katherine Wesseling Perry, Farzana Perwad, J. Wesley Pike, Mohammed S. Razzaque, Beatrice Richter, Isidro B. Salusky, Renal Section, Sarah Seiler-Mußler, Taylor Struemph, Marc G. Vervloet, Curtis Vrabec, Matthew J. Williams, Clinton B. Wright, Allen Zinkle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c13d3f4e067b721f26d0665211b969
https://doi.org/10.1016/b978-0-12-818036-5.01002-8
https://doi.org/10.1016/b978-0-12-818036-5.01002-8
The fibroblast growth factor 23 (FGF23) hormone is a key regulator of mineral ion homeostasis. Its metabolic activity depends on α-Klotho, an aging suppressor protein. A weak binding affinity for the glycosaminoglycan heparan sulfate enables FGF23 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab3d212246f564eb57860c569eb69d7
https://doi.org/10.1016/b978-0-12-818036-5.00002-1
https://doi.org/10.1016/b978-0-12-818036-5.00002-1
Autor:
Aykut Üren, Christopher S. Wilcox, York Tomita, Marcel O. Schmidt, Xiaoting Ma, Elena Tassi, Regina Goetz, Mattias Carlström, Khaled W. Kabbara, Anton Wellstein, Khalid Garman, Moosa Mohammadi, Anna T. Riegel
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Secreted FGF binding proteins (FGFBP) mobilize locally-acting paracrine FGFs from their extracellular storage. Here, we report that FGFBP3 (BP3) modulates fat and glucose metabolism in mouse models of metabolic syndrome. BP3 knockout mice exhibited a
Autor:
Regina Goetz, Lindsay M. Coe, Onyedikachi Aligbe, Anna Montagna, Rafiou Agoro, Stefano Rivella, Despina Sitara, Gurinder Bir Singh, Moosa Mohammadi
Publikováno v:
The FASEB Journal. 32:3752-3764
Severe anemia and iron deficiency are common complications in chronic kidney disease. The cause of renal anemia is multifactorial and includes decreased erythropoietin (Epo) production, iron deficiency, and inflammation, and it is currently treated w
Autor:
Regina Goetz, Murat Bastepe, Jordan M Spatz, Cumhur Aydin, Qing He, Lauren T Shumate, Antonius Plagge, Marc N. Wein, Julia Matthias, Moosa Mohammadi, Paola Divieti Pajevic
Publikováno v:
JCI INSIGHT
Dysregulated actions of bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23) result in several inherited diseases, such as X-linked hypophosphatemia (XLH), and contribute substantially to the mortality in kidney failure. Mechanisms g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f71bc63d1468be4b67b78a12d5614d
Autor:
Makoto Kuro-o, Sachdev S. Sidhu, Henry Quiñones, Regina Goetz, Carolyn Griffith, Danielle Carranza, Moosa Mohammadi, Orson W. Moe, Jianfeng Ye, Ming Chang Hu, Sarah L. Barker, Johanne Pastor, Jianning Zhang
Publikováno v:
Nephrology Dialysis Transplantation. 30:223-233
αKlotho is the prototypic member of the Klotho family and is most highly expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its actions include regulation of ion transport, cytoprotection, anti-oxidation and anti-
Autor:
Regina Goetz, Christopher Liddle, Annette R. Atkins, Olivia Osborn, Jerrold M. Olefsky, Ronald M. Evans, Jae Myoung Suh, Ruth T. Yu, Weiwei Fan, Yun-Qiang Yin, Moosa Mohammadi, Johan W. Jonker, Maryam Ahmadian, Michael Downes, Eiji Yoshihara, Zhifeng Huang, Weilin Liu, Denise E. Lackey, Rick Havinga, Theo H. van Dijk
Publikováno v:
Nature, 513(7518), 436-439. Nature Publishing Group
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance w