Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Regina G.D.M. van Kleef"'
1
Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro
Autor: Anke M. Tukker, Misha F. Vrolijk, Regina G.D.M. van Kleef, Dick T.H.M. Sijm, Remco H.S. Westerink
Publikováno v: Toxicology Letters, 373, 53-61. Elsevier Ireland Ltd
Tetrodotoxin (TTX) potently inhibits TTX-sensitive voltage-gated sodium (Na V) channels in nerve and muscle cells, potentially resulting in depressed neurotransmission, paralysis and death from respiratory failure. Since a wide range of pharmaceutica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a8304d44fc895fe72e824d2985c38f
https://pubmed.ncbi.nlm.nih.gov/36375636
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2
Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment
Autor: Remco H.S. Westerink, Regina G.D.M. van Kleef, Anke M Tukker, Aart de Groot, Fiona M J Wijnolts
Publikováno v: ALTEX.
A sizeable proportion of drug attrition is due to drug-induced seizures. Current available animal models frequently fail to predict human seizure liability. Therefore, there is a need for in vitro alternatives, preferably based on human-derived neuro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973726e3c3cada3c569483492ea9f106
https://doi.org/10.14573/altex.1907121
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3
Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells
Autor: Åke Bergman, Henk P.M. Vijverberg, Martin van den Berg, Remco H.S. Westerink, Milou M.L. Dingemans, Regina G.D.M. van Kleef, Aart de Groot
Publikováno v: Environmental Health Perspectives
Increasing concentrations of brominated flame retardants, in particular polybrominated diphenyl ethers (PBDEs), in the environment, human food chain, and human tissues raise concern about possible neurotoxic effects. High concentrations of PBDEs and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ccc522dfdbef6b9657eb924a4f5124
http://europepmc.org/articles/PMC2367675
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4
Block of Neuronal Nicotinic Acetylcholine Receptors by Organophosphate Insecticides
Autor: Regina G.D.M. van Kleef, Tjerk J. H. Bueters, Henk P.M. Vijverberg, Silvia Vailati, Chantal J. G. M. Smulders
Publikováno v: Toxicological Sciences. 82:545-554
Chronic and acute exposure to organophosphate (OP) pesticides may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. It is suggested that other brain proteins are in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a2f406b27c9515b0ea2ea75ab4291f
https://doi.org/10.1093/toxsci/kfh269
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5
Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase
Autor: Henk P.M. Vijverberg, Regina G.D.M. van Kleef, Chantal J. G. M. Smulders, Tjerk J. H. Bueters
Publikováno v: Toxicology and Applied Pharmacology. 193:139-146
Effects of commonly used carbamate pesticides on rat neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes have been investigated using the two-electrode voltage clamp technique. The potencies of these effects have been compa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9889261b2bc029e57366bc60ef30756
https://doi.org/10.1016/j.taap.2003.07.011
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7
Additive inhibition of human α1β2γ2 GABAA receptors by mixtures of commonly used drugs of abuse
Autor: Jan Meulenbelt, Regina G.D.M. van Kleef, Remco H.S. Westerink, Sijie Tan, Elise J.P. Hermans, Laura Hondebrink
Publikováno v: Neurotoxicology. 35
Yearly, exposure to drugs of abuse results in ∼1 million emergency department visits in the US. In ∼50% of the visits, stimulant drugs like cocaine and amphetamine-like substances (e.g. 3,4-methylenedioxymethamphetamine (MDMA, the main active ing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf0b21170b235cc37897cffcd54aca8
https://pubmed.ncbi.nlm.nih.gov/23266428
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8
Characterization of Ca2+-activated K+ channels in excised patches of human T lymphocytes
Autor: M. Oortgiesen, Henk P.M. Vijverberg, Jos A. H. Verheugen, Regina G.D.M. van Kleef
Publikováno v: Pflügers Archiv. 426:465-471
Ca(2+)-activated K+ [K(Ca)] channels were studied in excised patches of resting and activated human peripheral blood T lymphocytes. The K(Ca) channel had a single-channel conductance of 50 +/- 6 pS in symmetrical high-K+ solutions in the potential ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b626c70baf036ef14e0607727b1f8883
https://doi.org/10.1007/bf00378523
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10
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes
Autor: Henk P.M. Vijverberg, M. Oortgiesen, Regina G.D.M. van Kleef
Publikováno v: Brain Research. 518:11-18
Effects of local anesthetics and anticonvulsants on the pyrethroid-modified sodium current in cultured mouse neuroblastoma cells have been investigated using the suction pipette voltage clamp technique. In the presence of 10 μM of the pyrethroid del
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0173540bef3eea1d407a26bb71d5a851
https://doi.org/10.1016/0006-8993(90)90947-a
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