Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Regina C. M. Whitemarsh"'
Autor:
Sabine Pellett, Marite Bradshaw, William H. Tepp, Christina L. Pier, Regina C. M. Whitemarsh, Chen Chen, Joseph T. Barbieri, Eric A. Johnson
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked
Externí odkaz:
https://doaj.org/article/aedc52e97f8748b7906c9ad8d9dcb24e
Publikováno v:
Toxicon. 107:37-42
To date, over 40 subtypes of botulinum neurotoxins (BoNTs) have been identified. BoNTs are classified into 7 serotypes distinguished primarily by their antigenic properties, but also characterized by their unique SNARE targets and cleavage sites, hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee18727429bf5e698951973ca8ad2ed
https://doi.org/10.1016/j.toxicon.2015.06.021
https://doi.org/10.1016/j.toxicon.2015.06.021
Publikováno v:
Applied and Environmental Microbiology. 80:7415-7422
Clostridium botulinum subtype A4 neurotoxin (BoNT/A4) is naturally expressed in the dual-toxin-producing C. botulinum strain 657Ba at 100× lower titers than BoNT/B. In this study, we describe purification of recombinant BoNT/A4 (rBoNT/A4) expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc1b7adf844b1a3b493475d30cf51d1
https://doi.org/10.1128/aem.01795-14
https://doi.org/10.1128/aem.01795-14
Autor:
Christina L. Pier, Guangyun Lin, Marite Bradshaw, Sabine Pellett, Eric A. Johnson, William H. Tepp, Regina C. M. Whitemarsh, Jacob M. Scherf
Botulinum neurotoxins (BoNTs) are synthesized by Clostridium botulinum and exist as seven immunologically distinct serotypes designated A through G. For most serotypes, several subtypes have now been described based on nominal differences in the amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49c6d810a0b39f26a59a0942923a5c9
https://europepmc.org/articles/PMC3811745/
https://europepmc.org/articles/PMC3811745/
Publikováno v:
Biochemical and biophysical research communications. 427(2)
Cancerous cell lines have traditionally shown low sensitivity to laboratory or pharmaceutical preparations of botulinum neurotoxin. The work presented here demonstrates that the mouse neuroblastoma/rat glioma hybrid cell line NG108-15 is capable of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2ba27a42b935c700f8bf98fe7fca37
https://pubmed.ncbi.nlm.nih.gov/23000406
https://pubmed.ncbi.nlm.nih.gov/23000406
Autor:
Regina C. M. Whitemarsh, Marite Bradshaw, Jacob M. Scherf, William H. Tepp, Sabine Pellett, Eric A. Johnson, Christina L. Pier, Guangyun Lin
Publikováno v:
Toxicon. 93:S48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88137310f03ad4d3e0112d6d299b0fb0
https://doi.org/10.1016/j.toxicon.2014.11.159
https://doi.org/10.1016/j.toxicon.2014.11.159
Autor:
L.G. Chase, Eric A. Johnson, C. Stankewicz, Regina C. M. Whitemarsh, M.J. Strathman, William H. Tepp, Sabine Pellett
Publikováno v:
Toxicon. 68:78-79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b71af3d71d9db07e7aae59e9c713f5a
https://doi.org/10.1016/j.toxicon.2012.07.064
https://doi.org/10.1016/j.toxicon.2012.07.064
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90252 (2014)
PLoS ONE
PLoS ONE
Botulinum neurotoxins (BoNTs) are the most poisonous substances known and cause the severe disease botulism. BoNTs have also been remarkably effective as therapeutics in treating many neuronal and neuromuscular disorders. One of the hallmarks of BoNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f4360074ef316d410955d3183ce7c2
https://doi.org/10.1371/journal.pone.0090252
https://doi.org/10.1371/journal.pone.0090252