Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Regina, Macianskiene"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1359-1375
Objectives Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammation and pain. Most effects of NSAIDs are attributed to the inhibition of cyclooxygenases (COX). However, many NSAIDs may have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79b8906911ab0b500d0467002ac8a96
https://doi.org/10.1111/j.2042-7158.2012.01479.x
https://doi.org/10.1111/j.2042-7158.2012.01479.x
Publikováno v:
British Journal of Pharmacology. 161:416-429
BACKGROUND AND PURPOSE Interest in non-selective cation channels has increased recently following the discovery of transient receptor potential (TRP) proteins, which constitute many of these channels. EXPERIMENTAL APPROACH We used the whole-cell patc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a1a80d13da92f20ceb8c1e43d05a36
https://doi.org/10.1111/j.1476-5381.2010.00901.x
https://doi.org/10.1111/j.1476-5381.2010.00901.x
Publikováno v:
European Journal of Pharmacology. 632:52-59
Human ether a go-go related gene (hERG1) potassium channels underlie the repolarizing IKr current in the heart. Since they are targets of various drugs with cardiac side effects we tested whether the amiodarone derivative 2-methyl-3-(3,5-diiodo-4-car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f27ee1ce80c72a7f2e7ce87c455ce1b
https://doi.org/10.1016/j.ejphar.2010.01.010
https://doi.org/10.1016/j.ejphar.2010.01.010
Autor:
Bo Carlsson, Vida Gendviliene, Kanigula Mubagwa, Regina Macianskiene, Serena Viappiani, Bodo Brandts
Publikováno v:
Cardiovascular Drug Reviews. 21:216-235
KB130015 (KB015), a new drug structurally related to amiodarone, has been proposed to have antiarrhythmic properties. In contrast to amiodarone, KB015 markedly slows the kinetics of inactivation of Na(+) channels by enhancing concentration-dependentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bb7cf3bc33620c0066b92d209ec764
https://doi.org/10.1111/j.1527-3466.2003.tb00117.x
https://doi.org/10.1111/j.1527-3466.2003.tb00117.x
Autor:
Sergey I. Zakharov, Bogdan Amuzescu, Karin R. Sipido, Victoria M. Bolotina, Asfree Gwanyanya, Johan Vereecke, Kanigula Mubagwa, Regina Macianskiene
Publikováno v:
The Journal of Physiology. 559:761-776
Cardiac tissue expresses several TRP proteins as well as a Mg2+-inhibited, non-selective cation current (IMIC) that bears many characteristics of TRP channel currents. We used the whole-cell voltage clamp technique in pig and rat ventricular myocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c669f97b69a01c1987633434f9d10d16
https://doi.org/10.1113/jphysiol.2004.067637
https://doi.org/10.1113/jphysiol.2004.067637
Autor:
Ingo Wickenbrock, Rolf Borchard, V. Gendviliene, Mathias Meine, M. van Bracht, D. Dirkmann, M.W. Prull, Bodo Brandts, H.-J. Trappe, K. Mubagwa, Regina Macianskiene
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:134-142
2-Methyl-3- (3,5-diiodo-4-carboxymethoxybenzyl) benzofuran (KB130015; KB), a novel compound derived from amiodarone, has been proposed to have antiarrhythmic properties. Its effect on the G protein-coupled inward rectifying K+ current [IK(ACh) or IK(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0167a4ee2bcec794899007917d408e60
https://doi.org/10.1124/jpet.103.057646
https://doi.org/10.1124/jpet.103.057646
Autor:
Virginie Bito, Regina Macianskiene, Karin R. Sipido, Luc Raeymaekers, Kanigula Mubagwa, Bodo Brandts
Publikováno v:
British Journal of Pharmacology. 139:1469-1479
1. We have studied the acute cardiac electrophysiological effects of KB130015 (KB), a drug structurally related to amiodarone. Membrane currents and action potentials were measured at room temperature or at 37 degrees C during whole-cell patch-clamp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76edc777bc2ab19d2d4202ab1843a89e
https://doi.org/10.1038/sj.bjp.0705379
https://doi.org/10.1038/sj.bjp.0705379
Autor:
Regina Macianskiene, Victoria M. Bolotina, Tarik Smani, Kanigula Mubagwa, Endri Leno, Sergey I. Zakharov
Publikováno v:
British Journal of Pharmacology. 138:234-244
Previously we have described a monovalent cation (MC) current that could be unmasked by the removal of extracellular divalent cations in vascular smooth muscle cells (SMC) and cardiac myocytes, but specific and potent inhibitors of MC current have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a238d5fa8ccec9f90a4663f31d19d5bc
https://doi.org/10.1038/sj.bjp.0705074
https://doi.org/10.1038/sj.bjp.0705074
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:130-138
Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015 or KB) is a new drug, structurally related to amiodarone and to thyroid hormones. Its effects on cardiac voltage-dependent Na+ current (I Na) were studied in pig single ventricular myoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c942cfee8b1a503ac756685e56777d6
https://doi.org/10.1124/jpet.102.042218
https://doi.org/10.1124/jpet.102.042218
Autor:
Antanas Navalinskas, Irma Martisiene, Rimantas Treinys, Regina Macianskiene, Rimantas Benetis, Jonas Jurevičius, Mante Almanaityte
Publikováno v:
Biophysical Journal. 112:236a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2fbb9c981ca62b7893ef568a69a2a5
https://doi.org/10.1016/j.bpj.2016.11.1292
https://doi.org/10.1016/j.bpj.2016.11.1292