Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage

Autor: Alkmini A. Papadopoulou, Walter Stelzer, Mara Silber, Christine Schlosser, Charlotte Spitz, Martina Haug-Kröper, Tobias Straub, Stephan A. Müller, Stefan F. Lichtenthaler, Claudia Muhle-Goll, Dieter Langosch, Regina Fluhrer

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Abstract Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl protease that causes secretion of extracellular domains from type-II transmembrane proteins. Numerous Golgi-localized glycosidases and glucosyltransferases have be

Externí odkaz: https://doaj.org/article/9faad70949594762948f92ade4978291

Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis

Autor: Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert, Rebekka Wehner, Antje Tunger, Valentin Schatz, Patrick Neubert, Ann-Christine Gradtke, Janina Wolf, Stefan Rose-John, Paul Saftig, Alexander Dalpke, Jonathan Jantsch, Marc Schmitz, Regina Fluhrer, Ilse D. Jacobsen, Bernd Schröder

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response b

Externí odkaz: https://doaj.org/article/f2acefb3574e4b9da6fd801ea20dcfc5

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix

Autor: Charlotte Spitz, Christine Schlosser, Nadja Guschtschin-Schmidt, Walter Stelzer, Simon Menig, Alexander Götz, Martina Haug-Kröper, Christina Scharnagl, Dieter Langosch, Claudia Muhle-Goll, Regina Fluhrer

Publikováno v: iScience, Vol 23, Iss 12, Pp 101775- (2020)

Summary: Ectodomain (EC) shedding defines the proteolytic removal of a membrane protein EC and acts as an important molecular switch in signaling and other cellular processes. Using tumor necrosis factor (TNF)α as a model substrate, we identify a no

Externí odkaz: https://doaj.org/article/c3b63148f6c64088b959a5bd718b3a1c

Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model

Autor: Sophie C F Mauritz, Florian Röder, Christoph Westerhausen, Achim Wixforth, Stefan C Gerlach, Regina Fluhrer, Kathrin Baumgartner, Manuel S. Brugger, Christine Schlosser

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America 117(50), 31603-31613 (2020). doi:10.1073/pnas.2005203117

We report on in vitro wound-healing and cell-growth studies under the influence of radio-frequency (rf) cell stimuli. These stimuli are supplied either by piezoactive surface acoustic waves (SAWs) or by microelectrode-generated electric fields, both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c4fb0c1abda8393df3909d44223684
https://doi.org/10.1073/pnas.2005203117

Antigen Glycosylation Is a Central Regulator of CAR T Cell Efficacy

Autor: Katharina E. Hayer, Balraj Doray, Marco Ruella, Amanda Heard, Jufang Chang, Matthew D. Weitzman, Saar Gill, John Lattin, Nathan Singh, Regina Fluhrer, Jack Landmann, Mehmet Emrah Selli, Helen Ha, Abby M. Green

Publikováno v: Blood. 138:1721-1721

Chimeric antigen receptor-engineered T cells targeting CD19 (CART19) have revolutionized the management of relapsed and refractory B cell malignancies. Despite high initial response rates, many patients with acute lymphoblastic leukemia (ALL) ultimat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa8d5a31dd2ad49424e14d7113732bbe
https://doi.org/10.1182/blood-2021-146651