BAP1/ASXL1 recruitment and activation for H2A deubiquitination

Autor: Danny D. Sahtoe, Willem J. van Dijk, Reggy Ekkebus, Huib Ovaa, Titia K. Sixma

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The tumor suppressor BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression. Here, the authors show how BAP1’s C-terminal extension auto-recruits it to nucleosomes, where the DEUBAD domain of ASXL1 i

Externí odkaz: https://doaj.org/article/0ea8dc04cd7544a2834c03123e450572

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

Autor: Paul P. Geurink, Dennis Flierman, David Komander, Huib Ovaa, Manuela K. Hospenthal, Tycho E. T. Mevissen, Gerbrand J. van der Heden van Noort, Reggy Ekkebus

Publikováno v: Cell Chemical Biology, 23 (4)
Cell Chemical Biology

Summary Ubiquitin chains are important post-translational modifications that control a large number of cellular processes. Chains can be formed via different linkages, which determines the type of signal they convey. Deubiquitylating enzymes (DUBs) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48a6b37149f5a0c2dcb2beeb3b78fac
https://doi.org/10.1016/j.chembiol.2016.03.009

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

Autor: Huib Ovaa, Willem J. van Dijk, Danny D. Sahtoe, Titia K. Sixma, Reggy Ekkebus

Publikováno v: Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The deubiquitinating enzyme BAP1 is an important tumor suppressor that has drawn attention in the clinic since its loss leads to a variety of cancers. BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0080e2992fd29546b127133145fa4562
http://europepmc.org/articles/PMC4729829

Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes

Autor: Boris Rodenko, Rieuwert Hoppes, Laura Bies, Ton N. Schumacher, Patrick H.N. Celie, Robbert M. Spaapen, Tuna Mutis, Rimke Oostvogels, Pramila Rijal, Henk M. Lokhorst, Mireille Toebes, Julie H. Huang, Huib Ovaa, Reggy Ekkebus, Kim Wals, Maarten E. Emmelot, Jolien J. Luimstra

Publikováno v: Hoppes, R, Oostvogels, R, Luimstra, J J, Wals, K, Toebes, M, Bies, L, Ekkebus, R, Rijal, P, Celie, P H N, Huang, J H, Emmelot, M E, Spaapen, R M, Lokhorst, H, Schumacher, T N M, Mutis, T, Rodenko, B & Ovaa, H 2014, ' Altered peptide ligands revisited : Vaccine design through chemically modified hla-A2-Restricted t cell epitopes ', Journal of Immunology, vol. 193, no. 10, pp. 4803-4813 . https://doi.org/10.4049/jimmunol.1400800
Journal of Immunology, 193(10), 4803-4813. American Association of Immunologists

Virus or tumor Ag–derived peptides that are displayed by MHC class I molecules are attractive starting points for vaccine development because they induce strong protective and therapeutic cytotoxic T cell responses. In thus study, we show that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87627dc0fc7bc5e8970ad9a16eee154d
https://pubmed.ncbi.nlm.nih.gov/25311806

Technologies for MHC class I immunoproteomics

Autor: Ton N. Schumacher, Reggy Ekkebus, Rieuwert Hoppes, Huib Ovaa

Publikováno v: Journal of proteomics. 73(10)

T cell epitopes are peptides, for instance derived from foreign, mutated or overexpressed proteins, that are displayed by MHC molecules on the cell surface and that are recognized by T lymphocytes. Knowledge of the identity of epitopes displayed by M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e1d4d1e560eef24653c33e5cc593dc
https://pubmed.ncbi.nlm.nih.gov/20546957