Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content.

Autor: Rega, L. R.¹ (AUTHOR), Janssens, V.² (AUTHOR), Graversen, J. H.³ (AUTHOR), Moestrup, S. K.³ (AUTHOR), Cairoli, S.⁴ (AUTHOR), Goffredo, B. M.⁴ (AUTHOR), Nevo, N.⁵ (AUTHOR), Courtoy, G. E.⁶ (AUTHOR), Jouret, F.⁷ (AUTHOR), Antignac, C.⁵ (AUTHOR), Emma, F.¹ (AUTHOR), Pierreux, C. E.² (AUTHOR) christophe.pierreux@uclouvain.be, Courtoy, P. J.² (AUTHOR) pierre.courtoy@uclouvain.be

Publikováno v: Scientific Reports. 10/12/2023, Vol. 13 Issue 1, p1-14. 14p.

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Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis

Autor: Francesco Emma, Anna Pastore, Ester De Leo, Francesco Bellomo, Maria Antonietta De Matteis, Laura Giaquinto, Gianna Di Giovamberardino, Diego L. Medina, Laura Rita Rega, Anna Taranta, Sandro Montefusco, Diego di Bernardo

Publikováno v: International Journal of Molecular Sciences
Int J Mol Sci.
International Journal of Molecular Sciences, Vol 22, Iss 12829, p 12829 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12829

Diagnosis and cure for rare diseases represent a great challenge for the scientific community who often comes up against the complexity and heterogeneity of clinical picture associated to a high cost and time-consuming drug development processes. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1595fa757a3df4f335553826495443ca
http://europepmc.org/articles/PMC8657658