Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma.

Autor: Smith NJ; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; School of Biosciences, University of Kent, Canterbury, UK., Reddin I; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; Bio-R Bioinformatics Research Facility, Faculty of Medicine, University of Southampton, Southampton, UK., Policelli P; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; Cell, Gene and RNA Therapies, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Oh S; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA., Zainal N; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Howes E; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Jenkins B; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Tracy I; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Edmond M; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Sharpe B; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Amendra D; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Zheng K; Department of Pathology, University of Cambridge, Cambridge, UK., Egawa N; Department of Pathology, University of Cambridge, Cambridge, UK., Doorbar J; Department of Pathology, University of Cambridge, Cambridge, UK., Rao A; Gilead Sciences, Research Department, 324 Lakeside Dr, Foster City, CA, 94404, USA., Mahadevan S; Gilead Sciences, Research Department, 324 Lakeside Dr, Foster City, CA, 94404, USA., Carpenter MA; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Harris RS; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Ali S; Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK., Hanley C; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Buisson R; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA., King E; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Thomas GJ; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; Institute for Life Sciences, University of Southampton, Southampton, UK., Fenton TR; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. t.r.fenton@soton.ac.uk.; Institute for Life Sciences, University of Southampton, Southampton, UK. t.r.fenton@soton.ac.uk.

Publikováno v: The EMBO journal [EMBO J] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.

The viral origins of breast cancer.

Autor: Lawson, James S.¹ (AUTHOR) James.lawson@unsw.edu.au, Glenn, Wendy K.¹ (AUTHOR)

Publikováno v: Infectious Agents & Cancer. 8/26/2024, Vol. 19 Issue 1, p1-16. 16p.

Glycan-dependent HIV-specific neutralizing antibodies bind to cells of uninfected individuals.

Autor: Blazkova J; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Refsland EW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Clarridge KE; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Shi V; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Justement JS; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Huiting ED; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Gittens KR; Critical Care Medicine Department, Clinical Center, and., Chen X; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA., Schmidt SD; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA., Liu C; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA., Doria-Rose N; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA., Mascola JR; Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA., Heredia A; Institute of Human Virology, University of Maryland, Baltimore, Maryland, USA., Moir S; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID)., Chun TW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID).

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2019 Nov 01; Vol. 129 (11), pp. 4832-4837.

Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells.

Autor: Dennis, Madeline¹ (AUTHOR), Hurley, Alyssa² (AUTHOR), Bray, Nicholas¹ (AUTHOR), Cordero, Cameron^1,2 (AUTHOR), Ilagan, Jose¹ (AUTHOR), Mertz, Tony M.^1,2 (AUTHOR), Roberts, Steven A.^1,2 (AUTHOR) steven.roberts2@wsu.edu

Publikováno v: PLoS Genetics. 5/28/2024, Vol. 20 Issue 5, p1-20. 20p.

A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection.

Autor: Sneller MC; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Justement JS; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Gittens KR; Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD 20892, USA., Petrone ME; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Clarridge KE; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Proschan MA; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD 20892, USA., Kwan R; Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD 20892, USA., Shi V; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Blazkova J; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Refsland EW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Morris DE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Xu R; Profectus BioSciences Inc., Tarrytown, NY 10591, USA., Egan MA; Profectus BioSciences Inc., Tarrytown, NY 10591, USA., Eldridge JH; Profectus BioSciences Inc., Tarrytown, NY 10591, USA., Benko E; Maple Leaf Medical Clinic, Toronto, Ontario M5G 1K2, Canada., Kovacs C; Maple Leaf Medical Clinic, Toronto, Ontario M5G 1K2, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada., Moir S; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Chun TW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. twchun@nih.gov., Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2017 Dec 06; Vol. 9 (419).