Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Reetta, Vanhanen"'
Autor:
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila
Publikováno v:
Data in Brief, Vol 35, Iss , Pp 106751- (2021)
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive re
Externí odkaz:
https://doaj.org/article/394d75d0da81404ab6d2e1527f3d4877
Autor:
Jari Saramäki, Nelli Heikkilä, Dawit A. Yohannes, Reetta Vanhanen, T. Petteri Arstila, Ilkka P. Mattila, Iivari Kleino
Publikováno v:
Molecular Immunology. 127:112-123
A highly diverse repertoire of T cell antigen receptors (TCR) is created in the thymus by recombination of gene segments and the insertion or deletion of nucleotides at the junctions. Using next-generation TCR sequencing we define here the features o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141824122e6fd4942f2996d0acb51df
https://doi.org/10.1016/j.molimm.2020.09.003
https://doi.org/10.1016/j.molimm.2020.09.003
Autor:
Nelli Heikkilä, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila, T. Sakari Jokiranta, Silja Sormunen, Reetta Vanhanen, Seppo Meri, Dawit A. Yohannes, Päivi Saavalainen, David Hamm, Hanna Jarva
Publikováno v:
European Journal of Immunology. 50:748-751
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdcc885d2098414af350bbcb4730ddb
https://doi.org/10.1002/eji.201948404
https://doi.org/10.1002/eji.201948404
Autor:
Iivo, Hetemäki, Meri, Kaustio, Matias, Kinnunen, Nelli, Heikkilä, Salla, Keskitalo, Kirsten, Nowlan, Simo, Miettinen, Joona, Sarkkinen, Virpi, Glumoff, Noora, Andersson, Kaisa, Kettunen, Reetta, Vanhanen, Katariina, Nurmi, Kari K, Eklund, Johannes, Dunkel, Mikko I, Mäyränpää, Heinrich, Schlums, T Petteri, Arstila, Kai, Kisand, Yenan T, Bryceson, Pärt, Peterson, Ulla, Otava, Jaana, Syrjänen, Janna, Saarela, Markku, Varjosalo, Eliisa, Kekäläinen
Publikováno v:
Science immunology. 6(65)
The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::653382fc70b384af21c884f81f1d52d3
https://pubmed.ncbi.nlm.nih.gov/34826260
https://pubmed.ncbi.nlm.nih.gov/34826260
Autor:
Jaana Syrjänen, Heinrich Schlums, Yenan T. Bryceson, Iivo Hetemäki, Salla Keskitalo, Meri Kaustio, Noora Andersson, Nelli Heikkilä, Kari K. Eklund, Virpi Glumoff, Matias Kinnunen, Mikko I. Mäyränpää, Simo Miettinen, T. Petteri Arstila, Joona Sarkkinen, Kai Kisand, Johannes Dunkel, Reetta Vanhanen, Katariina Nurmi, Ulla Otava, Eliisa Kekäläinen, Kaisa Kettunen, Markku Varjosalo, Janna Saarela, Pärt Peterson
The IKAROS family transcription factors regulate lymphocyte development. Loss-of-function variants in IKZF1 cause primary immunodeficiency, but IKAROS family members IKZF2 and IKZF3 have not yet been associated with immunodeficiency yet. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de462bc93bc0f7f14249247ed95d486b
https://doi.org/10.1101/2021.08.25.21262015
https://doi.org/10.1101/2021.08.25.21262015
Autor:
Nelli, Heikkilä, Iivari, Kleino, Reetta, Vanhanen, Dawit A, Yohannes, Ilkka P, Mattila, Jari, Saramäki, T Petteri, Arstila
Publikováno v:
Data in Brief
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd039341a11ae01de11d1e409c72bb6b
https://pubmed.ncbi.nlm.nih.gov/33553521
https://pubmed.ncbi.nlm.nih.gov/33553521
Autor:
Hanna Jarva, T. Petteri Arstila, T. Sakari Jokiranta, Reetta Vanhanen, David Hamm, Ilkka Mattila, Nelli Heikkilä, Dawit A. Yohannes, Päivi Saavalainen, Jari Saramäki, Seppo Meri, Silja Sormunen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc6c1b42a651a9a38456b1f1eb004dff
https://doi.org/10.1002/eji.201948404/v2/response1
https://doi.org/10.1002/eji.201948404/v2/response1
Publikováno v:
Journal of Leukocyte Biology. 100:491-498
Although mature human FOXP3+ regulatory T cells are CD127 (IL-7Rα) negative, CD4+CD8+ FOXP3+ thymocytes express relatively high levels of CD127 and are responsive to IL-7. However, the role of IL-7 in human regulatory T cell development is poorly kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1316259ee11b6b57195b5ca68a7af310
https://doi.org/10.1189/jlb.1a0415-164r
https://doi.org/10.1189/jlb.1a0415-164r
Publikováno v:
Cellular Immunology. 347:104026
The natural CD25 + FOXP3 + regulatory T cell (Treg) population is generated as a distinct lineage in the thymus, but the details of Treg development in humans remain unclear, and the timing of Treg commitment is also contested. Here we have analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429a3acd38ef1adbe1e8af727dae3cae
https://doi.org/10.1016/j.cellimm.2019.104026
https://doi.org/10.1016/j.cellimm.2019.104026
Publikováno v:
Scandinavian journal of immunology.
Thymic commitment of human FOXP3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c5b2756c2318e9b00b787da9fe6efbc
https://pubmed.ncbi.nlm.nih.gov/29904934
https://pubmed.ncbi.nlm.nih.gov/29904934