Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo

Autor: Reetobrata Basu, Yanrong Qian, Samuel Mathes, Joseph Terry, Nathan Arnett, Trent Riddell, Austin Stevens, Kevin Funk, Stephen Bell, Zac Bokal, Courtney Batten, Cole Smith, Isaac Mendez-Gibson, Silvana Duran-Ortiz, Grace Lach, Patricia Alexandra Mora-Criollo, Prateek Kulkarni, Emily Davis, Elizabeth Teaford, Darlene E. Berryman, Edward O. List, Sebastian Neggers, John J. Kopchick

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Knockdown of GH receptor (GHR) in melanoma cells in vitro downregulates ATP-binding cassette-containing (ABC) transporters and sensitizes them to anti-cancer drug treatments. Here we aimed to determine whether a GHR antagonist (GHRA) could control ca

Externí odkaz: https://doaj.org/article/d2ffbe802ebd4cbd9ac35e71d0449a98

Increased Fibrosis in White Adipose Tissue of Male and Female bGH Transgenic Mice Appears Independent of TGF-β Action

Autor: Stephen Bell, Jonathan A Young, Edward O List, Reetobrata Basu, Delaney K Geitgey, Grace Lach, Kevin Lee, Deborah Swegan, Lydia J Caggiano, Shigeru Okada, John J Kopchick, Darlene E Berryman

Publikováno v: Endocrinology. 164

Fibrosis is a pathological state caused by excess deposition of extracellular matrix proteins in a tissue. Male bovine growth hormone (bGH) transgenic mice experience metabolic dysfunction with a marked decrease in lifespan and with increased fibrosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::274334aacb277010e6e00b2a6b993d59
https://doi.org/10.1210/endocr/bqad038

Abstract 408: Novel growth hormone receptor antagonist with discrete PEGylations markedly improve response to therapy in human pancreatic and bile duct cancers in mice

Autor: Reetobrata Basu, John J. Kopchick

Publikováno v: Cancer Research. 83:408-408

Here we present a new and improved GHR antagonist candidate (compound G) with novel discrete PEGylations exhibiting marked efficacy in synergizing anti-cancer therapies. The American Cancer Society estimates the 5-year survival rates of pancreatic ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d87ed6d2da5f0b2afa939e3c4c24a82c
https://doi.org/10.1158/1538-7445.am2023-408

Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer

Autor: John J. Kopchick, Reetobrata Basu, Darlene E. Berryman, Jens O. L. Jorgensen, Gudmundur Johannsson, Vishwajeet Puri

Publikováno v: Nat Rev Endocrinol
Kopchick, J J, Basu, R, Berryman, D E, Jorgensen, J O L, Johannsson, G & Puri, V 2022, ' Covert actions of growth hormone : fibrosis, cardiovascular diseases and cancer ', Nature Reviews. Endocrinology, vol. 18, no. 9, pp. 558-573 . https://doi.org/10.1038/s41574-022-00702-6

Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have investigated its structure, how it interacts with the GH receptor and its multiple actions. These include effects on growth, substrate metabolism, body composi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d657ab88444a45e0f8b700a1157ec4
https://pubmed.ncbi.nlm.nih.gov/35750929

Growth hormone modulates Trypanosoma cruzi infection in vitro

Autor: Patricia Mora-Criollo, Reetobrata Basu, Yanrong Qian, Jaime A. Costales, Jaime Guevara-Aguirre, Mario J. Grijalva, John J. Kopchick

Publikováno v: Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 64

Chagas disease (CD) is caused by the protozoan parasite, Trypanosoma cruzi. It affects 7 to 8 million people worldwide and leads to approximately 50,000 deaths per year. In vitro and in vivo studies had demonstrated that Trypanosoma cruziinfection ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80c1484121070ae9fb23179f090b45e
https://pubmed.ncbi.nlm.nih.gov/35490602