Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Reesha Solanki"'
Autor:
Sultan Ahmed, Robert. T. Johnson, Reesha Solanki, Teclino Afewerki, Finn Wostear, Derek. T. Warren
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of the aortic wall and normally exist in a quiescent, contractile phenotype where actomyosin-derived contractile forces maintain vascular tone. However, VSMCs are
Externí odkaz:
https://doaj.org/article/f6b20192be7945828e70e7a04b61a02e
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecu
Externí odkaz:
https://doaj.org/article/3d32b0334d36473a86f18126267d3d4d
Autor:
Robert Johnson, Sultan Ahmed, Finn Wostear, Reesha Solanki, Christopher Morris, Stefan Bidula, Derek Warren
Decreased aortic compliance is a precursor to numerous cardiovascular diseases. Compliance is regulated by the rigidity of the aortic wall and the vascular smooth muscle cells (VSMCs) within it. Extracellular matrix stiffening, observed during ageing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad8fb5045b90b4da8732c7ed195052ae
https://doi.org/10.22541/au.168130121.10786946/v1
https://doi.org/10.22541/au.168130121.10786946/v1
Autor:
Robert T. Johnson, Sultan Ahmed, Finn Wostear, Reesha Solanki, Chris J. Morris, Stefan Bidula, Derek T. Warren
Abstract FigureBackground and PurposeDecreased aortic compliance is a precursor to numerous cardiovascular diseases. Compliance is regulated by the rigidity of the aortic wall and the vascular smooth muscle cells (VSMCs) within it. Extracellular matr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4045d85b78022e3fd54fde4f18ffec6d
https://doi.org/10.1101/2022.11.23.517637
https://doi.org/10.1101/2022.11.23.517637
Publikováno v:
Biophysical Reviews
Arterial smooth muscle cells (ASMCs), the predominant cell type within the arterial wall, detect and respond to external mechanical forces. These forces can be derived from blood flow (i.e. pressure and stretch) or from the supporting extracellular m
Publikováno v:
Basic science.
Publikováno v:
Basic science.
Publikováno v:
Basic science.
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecu
Publikováno v:
Circulation Research. 125
Background: Protein kinase C (PKC) has been linked to cardiomyocyte hypertrophy. However, the exact role of different PKC isoforms in mediating the hypertrophic response remains controversial and both classical and novel isoforms have been suggested