triSPIM: light sheet microscopy with isotropic super-resolution

Autor: Manton, JD, Rees, EJ

We propose a three-objective light sheet microscopy geometry which, through a combination of skewed lattice light sheet excitation through two objectives and the computational fusion of images taken from two separate lens pairings, would allow for is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dc5d53e83aba778ec837c9f2f1006a

Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets

Autor: Gielen, F, Butz, M, Rees, EJ, Erdelyi, M, Moschetti, T, Hyvönen, M, Edel, JB, Kaminski, CF, Hollfelder, F

Fluorescence anisotropy measurements of reagents compartmentalized into individual nanoliter droplets are shown to yield high-resolution binding curves from which precise dissociation constants (K$_{d}$) for protein-peptide interactions can be inferr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da41cf3551b28bb9dd1394d3872ad38b

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Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.

Autor: Lautenschläger J; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom janin.lautenschlaeger@gmail.com; gsk20@cam.ac.uk., Wagner-Valladolid S; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Stephens AD; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Fernández-Villegas A; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Hockings C; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Mishra A; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Manton JD; Quantitative Imaging Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Fantham MJ; Laser Analytics Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Lu M; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Rees EJ; Quantitative Imaging Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Kaminski CF; Laser Analytics Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom., Kaminski Schierle GS; Molecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge, United Kingdom janin.lautenschlaeger@gmail.com; gsk20@cam.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Jul 24; Vol. 295 (30), pp. 10138-10152. Date of Electronic Publication: 2020 May 08.