Precision modulation of dysbiotic adult microbiomes with a human-milk-derived synbiotic reshapes gut microbial composition and metabolites.

Autor: Button JE; Prolacta Bioscience, Duarte, CA 91010, USA., Cosetta CM; Prolacta Bioscience, Duarte, CA 91010, USA., Reens AL; Prolacta Bioscience, Duarte, CA 91010, USA., Brooker SL; Prolacta Bioscience, Duarte, CA 91010, USA., Rowan-Nash AD; Prolacta Bioscience, Duarte, CA 91010, USA., Lavin RC; Prolacta Bioscience, Duarte, CA 91010, USA., Saur R; Prolacta Bioscience, Duarte, CA 91010, USA., Zheng S; Prolacta Bioscience, Duarte, CA 91010, USA., Autran CA; Prolacta Bioscience, Duarte, CA 91010, USA., Lee ML; Prolacta Bioscience, Duarte, CA 91010, USA; Department of Biostatistics, University of California Los Angeles, Fielding School of Public Health, Los Angeles, CA 90095, USA., Sun AK; Prolacta Bioscience, Duarte, CA 91010, USA., Alousi AM; Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA., Peterson CB; Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA., Koh AY; Department of Pediatrics, Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA; Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Rechtman DJ; Prolacta Bioscience, Duarte, CA 91010, USA., Jenq RR; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA., McKenzie GJ; Prolacta Bioscience, Duarte, CA 91010, USA. Electronic address: gmckenzie@prolacta.com.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2023 Sep 13; Vol. 31 (9), pp. 1523-1538.e10. Date of Electronic Publication: 2023 Aug 31.

Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome.

Autor: Swaminathan G; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Citron M; Infectious Diseases and Vaccine Research, MRL, Merck & Co., Inc., West Point, PA 19486, USA., Xiao J; Infectious Diseases and Vaccine Research, MRL, Merck & Co., Inc., West Point, PA 19486, USA., Norton JE Jr; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Reens AL; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Topçuoğlu BD; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Maritz JM; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Lee KJ; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, MRL, Merck & Co. Inc., Rahway, NJ 07065, USA., Freed DC; Infectious Diseases and Vaccine Research, MRL, Merck & Co., Inc., West Point, PA 19486, USA., Weber TM; Infectious Diseases and Vaccine Research, MRL, Merck & Co., Inc., West Point, PA 19486, USA., White CH; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Kadam M; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Spofford E; Safety Assessment and Laboratory Animal Research, MRL, Merck & Co. Inc., Boston, MA 02115, USA., Bryant-Hall E; Safety Assessment and Laboratory Animal Research, MRL, Merck & Co. Inc., Boston, MA 02115, USA., Salituro G; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, MRL, Merck & Co. Inc., Rahway, NJ 07065, USA., Kommineni S; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Liang X; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Danilchanka O; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Fontenot JA; New Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA 70503, USA., Woelk CH; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Gutierrez DA; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Hazuda DJ; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA.; Infectious Diseases and Vaccine Research, MRL, Merck & Co., Inc., West Point, PA 19486, USA., Hannigan GD; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2021 Nov 17; Vol. 9 (11). Date of Electronic Publication: 2021 Nov 17.

Salmonella enterica Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice.

Autor: Reens AL; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, USA., Nagy TA; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, USA., Detweiler CS; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, USA detweile@colorado.edu.

Publikováno v: Infection and immunity [Infect Immun] 2019 Dec 17; Vol. 88 (1). Date of Electronic Publication: 2019 Dec 17 (Print Publication: 2019).

A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load.

Autor: Reens AL; Department of Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America., Crooks AL; Department of Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America., Su CC; Department of Pharmacology, Case Western Reserve, Cleveland OH, United States of America., Nagy TA; Department of Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America., Reens DL; Department of Physics, University of Colorado Boulder, Boulder, CO, United States of America.; JILA, National Institutes of Standards and Technology and University of Colorado Boulder, Boulder, CO, United States of America., Podoll JD; Department of Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America., Edwards ME; Department of Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America., Yu EW; Department of Pharmacology, Case Western Reserve, Cleveland OH, United States of America., Detweiler CS; Department of Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2018 Jun 07; Vol. 14 (6), pp. e1007115. Date of Electronic Publication: 2018 Jun 07 (Print Publication: 2018).