Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Reenal Pattni"'
Autor:
Agnieszka Kalinowski, Joanna Liliental, Lauren A. Anker, Omer Linkovski, Collin Culbertson, Jacob N. Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F. Hallmayer, Elizabeth D. Mellins, Jacob S. Ballon, Ruth O’Hara, Douglas F. Levinson, Alexander E. Urban
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression. C4-anaphylatoxin (C4-ana) is a C4 prote
Externí odkaz:
https://doaj.org/article/4b3178d6ebbb4381a59e08025b31ba7d
Autor:
Yifan Wang, Taejeong Bae, Jeremy Thorpe, Maxwell A. Sherman, Attila G. Jones, Sean Cho, Kenneth Daily, Yanmei Dou, Javier Ganz, Alon Galor, Irene Lobon, Reenal Pattni, Chaggai Rosenbluh, Simone Tomasi, Livia Tomasini, Xiaoxu Yang, Bo Zhou, Schahram Akbarian, Laurel L. Ball, Sara Bizzotto, Sarah B. Emery, Ryan Doan, Liana Fasching, Yeongjun Jang, David Juan, Esther Lizano, Lovelace J. Luquette, John B. Moldovan, Rujuta Narurkar, Matthew T. Oetjens, Rachel E. Rodin, Shobana Sekar, Joo Heon Shin, Eduardo Soriano, Richard E. Straub, Weichen Zhou, Andrew Chess, Joseph G. Gleeson, Tomas Marquès-Bonet, Peter J. Park, Mette A. Peters, Jonathan Pevsner, Christopher A. Walsh, Daniel R. Weinberger, Brain Somatic Mosaicism Network, Flora M. Vaccarino, John V. Moran, Alexander E. Urban, Jeffrey M. Kidd, Ryan E. Mills, Alexej Abyzov
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting mosai
Externí odkaz:
https://doaj.org/article/ed8ec2a7cb594e94ba5848bb9fd9be5a
Autor:
Taejeong, Bae, Liana, Fasching, Yifan, Wang, Joo Heon, Shin, Milovan, Suvakov, Yeongjun, Jang, Scott, Norton, Caroline, Dias, Jessica, Mariani, Alexandre, Jourdon, Feinan, Wu, Arijit, Panda, Reenal, Pattni, Yasmine, Chahine, Rebecca, Yeh, Rosalinda C, Roberts, Anita, Huttner, Joel E, Kleinman, Thomas M, Hyde, Richard E, Straub, Christopher A, Walsh, Alexander E, Urban, James F, Leckman, Daniel R, Weinberger, Flora M, Vaccarino, Sirisha, Pochareddy
Publikováno v:
Science. 377:511-517
We analyzed 131 human brains (44 neurotypical, 19 with Tourette syndrome, 9 with schizophrenia, and 59 with autism) for somatic mutations after whole genome sequencing to a depth of more than 200×. Typically, brains had 20 to 60 detectable single-nu
Autor:
Xianglong Zhang, Alexander E. Urban, Wing Hung Wong, Shining Ma, Reenal Pattni, Carolin Purmann, Kasey N. Davis, Joachim Hallmayer, Anima Shrestha, Marcus Ho, Yiling Huang, Jonathan A. Bernstein, Siming Zhang
Publikováno v:
Biol Psychiatry
Background The 15q13.3 microdeletion is associated with several neuropsychiatric disorders, including autism and schizophrenia. Previous association and functional studies have investigated the potential role of several genes within the deletion in n
Autor:
Bo Zhou, GiWon Shin, Lisanne Vervoort, Stephanie Greer, Yiling Huang, Tanmoy Roychowdhury, Reenal Pattni, Alexej Abyzov, Joris Vermeesch, Hanlee Ji, Alexander Urban
Publikováno v:
European Neuropsychopharmacology. 63:e88-e89
Autor:
Shi-Bin Li, Valentina Martinez Damonte, Chong Chen, Gordon X. Wang, Justus M. Kebschull, Hiroshi Yamaguchi, Wen-Jie Bian, Carolin Purmann, Reenal Pattni, Alexander Eckehart Urban, Philippe Mourrain, Julie A. Kauer, Grégory Scherrer, Luis de Lecea
Publikováno v:
Science
INTRODUCTION: Sleep destabilization is strongly associated with aging and cognitive function decline. Despite sleep fragmentation being central to the most prevalent complaints of sleep problems in elderly populations, the mechanistic underpinnings o
Autor:
Reenal Pattni, Allan L. Reiss, Atanas D. Stankov, Thomas J. Ward, Wing Hung Wong, David S. Hong, Xianglong Zhang, Sharon Bade Shrestha, Alexander E. Urban, Shining Ma, Joachim Hallmayer, Zhana Duren, Marcus Ho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Turner syndrome (TS) is caused by having only one X chromosome (X0), and Klinefelter syndrome (KS) by having two X chromosomes and one Y chromosome (XXY). In this study we carried out a direct comparison analysis of the effect these chro
Autor:
Ruth O'Hara, Jacob N. Hall, Joanna Liliental, Chiara Sabatti, Elizabeth D. Mellins, Reenal Pattni, Douglas L. Noordsy, Collin J. Culbertson, Alexander E. Urban, Agnieszka Kalinowski, Omer Linkovski, Joachim Hallmayer, Jacob S. Ballon, Douglas F. Levinson, Lauren A. Anker
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry
Translational Psychiatry
Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression. C4-anaphylatoxin (C4-ana) is a C4 protein fragme
Autor:
Yifan Wang, Taejeong Bae, Thorpe, Jeremy, Sherman, Maxwell A., Jones, Attila G., Cho, Sean, Daily, Kenneth, Yanmei Dou, Ganz, Javier, Galor, Alon, Lobon, Irene, Reenal Pattni, Rosenbluh, Chaggai, Tomasi, Simone, Tomasini, Livia, Xiaoxu Yang, Zhou, Bo, Schahram Akbarian, Ball, Laurel L., Bizzotto, Sara, Emery, Sarah B., Doan, Ryan, Fasching, Liana, Yeongjun Jang, Juan, David, Lizano, Esther, Lovelace J. Luquette, Moldovan, John B., Rujuta Narurkar, Oetjens, Matthew T., Rodin, Rachel E., Shobana Sekar, Shin, Joo Heon, Soriano, Eduardo, Straub, Richard E., Weichen Zhou, Chess, Andrew, Gleeson, Joseph G., Marquès-Bonet, Tomas, Park, Peter J., Peters, Mette A., Pevsner, Jonathan, Walsh, Christopher A., Weinberger, Daniel R., Vaccarino, Flora M., Moran, John V., Urban, Alexander E., Kidd, Jeffrey M., Mills, Ryan E., Abyzov, Alexej
Additional file 1:. Figure S1-S13, Table S1,S3,S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413ecba219b16d69d0ff1dcb5a6fc5a3
Autor:
Dmitri A. Petrov, Flora M. Vaccarino, Bo Zhou, Hannes Vogel, Alexej Abyzov, Carol A. Tamminga, John V. Moran, Steven A. Sloan, Ben A. Barres, Alexander E. Urban, Kelly Gleason, Agnieszka Kalinowski, Xiaowei Zhu, Jessica Mariani, Douglas F. Levinson, Reenal Pattni, Anna-Sophie Fiston-Lavier, Chunfeng Tan, Laramie E. Duncan
Publikováno v:
Nature neuroscience
Retrotransposons can cause somatic genome variation in the human nervous system, which is hypothesized to have relevance to brain development and neuropsychiatric disease. However, the detection of individual somatic mobile element insertions present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbff37eef3256b2ec56f475ed474e6c
http://hdl.handle.net/10230/56582
http://hdl.handle.net/10230/56582