Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Reena V. Kartha"'
Autor:
Nishitha R. Pillai, Reena V. Kartha
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/7fe9ae00c6554c359928c1416233fb8f
Autor:
Snigdha Pusalavidyasagar, Laurie B. Hovde, Jessie Lee, Lei Zhang, Adnan Abbasi, Reena V. Kartha
Publikováno v:
International Journal of Translational Medicine, Vol 2, Iss 3, Pp 408-418 (2022)
Patients with obstructive sleep apnea (OSA) have an increased risk of cardiovascular disease (CVD). Nitric oxide (NO) and heme oxygenase-1 (HO-1) affect vascular tone and are vasoprotective. Furthermore, hydrogen sulfide (H2S), an HO-1 inducer, is kn
Externí odkaz:
https://doaj.org/article/27df35bfcfde4ddb85836d0dbf34079a
Autor:
Dorian M. Cheff, Alysson R. Muotri, Brent R. Stockwell, Edward E. Schmidt, Qitao Ran, Reena V. Kartha, Simon C. Johnson, Plavi Mittal, Elias S. J. Arnér, Kristen M. Wigby, Matthew D. Hall, Sanath Kumar Ramesh
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-15 (2021)
Abstract Background Extremely rare progressive diseases like Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD) can be neonatally lethal and therefore go undiagnosed or are difficult to treat. Recent sequencing efforts have linked this disease to
Externí odkaz:
https://doaj.org/article/b03c183bb33b4ee8b5828e0234f4c132
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1316 (2023)
N-acetylcysteine (NAC), a precursor of cysteine and, thereby, glutathione (GSH), acts as an antioxidant through a variety of mechanisms, including oxidant scavenging, GSH replenishment, antioxidant signaling, etc. Owing to the variety of proposed tar
Externí odkaz:
https://doaj.org/article/88f576b8c9b14a66a90c1468067aedb6
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9189 (2022)
The lack of reliable biomarkers is a significant challenge impeding progress in orphan drug development. For appropriate interpretation of intervention-based results or for evaluating candidate biomarkers, other things being equal, lower variability
Externí odkaz:
https://doaj.org/article/a64d582ef8a54fd0a7be51fd73756cd4
Autor:
Corjena Cheung, Rozina Bhimani, Jean F. Wyman, Jürgen Konczak, Lei Zhang, Usha Mishra, Marcia Terluk, Reena V. Kartha, Paul Tuite
Publikováno v:
Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-11 (2018)
Abstract Objective To examine the feasibility, acceptability, and preliminary effects of Hatha yoga on oxidative stress, motor function, and non-motor symptoms among individuals with Parkinson’s disease (PD). Methods The study has a pilot randomize
Externí odkaz:
https://doaj.org/article/37ea8bfdf5ea41198f20903812dfd0b9
Autor:
Reena V. Kartha, Marcia R. Terluk, Roland Brown, Abigail Travis, Usha R. Mishra, Kyle Rudser, Heather Lau, Jeanine R. Jarnes, James C. Cloyd, Neal J. Weinreb
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss , Pp 100667- (2020)
Gaucher disease is an autosomal recessive metabolic disorder caused by mutations in GBA1, which encodes for the lysosomal hydrolase enzyme, β-glucocerebrosidase. The resulting misfolded protein can trigger endoplasmic reticulum stress and an unfolde
Externí odkaz:
https://doaj.org/article/3addd5bb4ea74ca7805b93c76f5bada2
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1826 (2021)
The accumulation of saturated very long-chain fatty acids (VLCFA, ≥C22:0) due to peroxisomal impairment leads to oxidative stress and neurodegeneration in X-linked adrenoleukodystrophy (ALD). Among the neural supporting cells, myelin-producing olig
Externí odkaz:
https://doaj.org/article/fc2d47677d5946a2bac09105e78d4879
Autor:
Jie Zhou, Marcia R. Terluk, Lisa Basso, Usha R. Mishra, Paul J. Orchard, James C. Cloyd, Henning Schröder, Reena V. Kartha
Publikováno v:
Biomedicines, Vol 8, Iss 8, p 240 (2020)
Oligodendrocytic injury by oxidative stress can lead to demyelination, contributing to neurodegeneration. We investigated the mechanisms by which an antioxidant, N-acetylcysteine (NAC), reduces oxidative stress in murine oligodendrocytes. We used nor
Externí odkaz:
https://doaj.org/article/22d3edee0eea42aaa286523858ce9e08
Publikováno v:
Diagnostics, Vol 3, Iss 1, Pp 84-104 (2013)
MicroRNAs (miRNAs) are small non-coding RNA molecules, which in recent years have emerged to have enormous potential as biomarkers. Recently, there have been significant developments in understanding miRNA biogenesis, their regulatory mechanisms and
Externí odkaz:
https://doaj.org/article/830ce46a6cee4725992b8ba45542e562