Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Reena Mourya"'
Autor:
Julie Osborn, Reena Mourya, Unmesha Thanekar, Weizhe Su, Lin Fei, Pranavkumar Shivakumar, Jorge A. Bezerra
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 995-1004 (2022)
Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large‐scale proteomics
Externí odkaz:
https://doaj.org/article/8902c9dcdb374a04873e11b2f0fcda7f
Autor:
Jai Junbae Jee, Li Yang, Pranavkumar Shivakumar, Pei-pei Xu, Reena Mourya, Unmesha Thanekar, Pu Yu, Yu Zhu, Yongkang Pan, Haibin Wang, Xufei Duan, Yongqin Ye, Bin Wang, Zhu Jin, Yuanmei Liu, Zhiqing Cao, Miki Watanabe-Chailland, Lindsey E. Romick-Rosendale, Michael Wagner, Lin Fei, Zhenhua Luo, Nicholas J. Ollberding, Shao-tao Tang, Jorge A. Bezerra
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The pathogenesis of biliary atresia remains poorly understood. Here, the authors report that maternal butyrate treatment alters the gut microbiome and glutamine/hypoxanthine metabolites similar to human subjects, and suppresses biliary atresia in new
Externí odkaz:
https://doaj.org/article/f8ba779a49e84d54b38c7a365e7df194
Autor:
Astha Malik, Unmesha Thanekar, Surya Amarachintha, Reena Mourya, Shreya Nalluri, Alexander Bondoc, Pranavkumar Shivakumar
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a leading cause of death in the US and worldwide. HCC remains a global health problem and is highly aggressive with unfavorable prognosis. Even with surgical interv
Externí odkaz:
https://doaj.org/article/b6afafcdbd614ed3a613938a56aef9f0
Autor:
Anna L Peters, Zhenhua Luo, Jun Li, Reena Mourya, Yunguan Wang, Phillip Dexheimer, Pranav Shivakumar, Bruce Aronow, Jorge A Bezerra
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215481 (2019)
IL-33 promotes type 2 immunity, epithelial repair, and tissue fibrosis by activating group 2 innate lymphoid cells (ILC2). ILC2 lack all known surface markers of mature T, B, NK, and myeloid cell lineages (Linneg), express the IL-33 receptor ST2, and
Externí odkaz:
https://doaj.org/article/37cf91c7fbbb4981ad7d34c19f94e80b
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182089 (2017)
Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signali
Externí odkaz:
https://doaj.org/article/e4441947fa45492a9aa69745227c00a8
Autor:
James E Squires, Pranavkumar Shivakumar, Reena Mourya, Kazuhiko Bessho, Stephanie Walters, Jorge A Bezerra
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127191 (2015)
Biliary atresia is a rapidly progressive obstructive cholangiopathy of infants. Mechanistic studies in the mouse model of Rhesus rotavirus (RRV)-induced biliary atresia have linked the importance of effector lymphocytes to the pathogenesis of extrahe
Externí odkaz:
https://doaj.org/article/c8170816948d45b3a6c031b102ac86cb
Autor:
Xiaofeng Li, Surya Amarachintha, Li Yang, Zhenhua Luo, Hiroaki Ayabe, Reena Mourya, Unmesha Thanekar, Pranavkumar Shivakumar, Jorge A. Bezerra
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Biliary atresia is a severe inflammatory and fibrosing cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a prenatal onset of liver dysfunction. Our aim was to investigate the mechanisms lin
Autor:
Greg Tiao, Reena Mourya, Todd M. Jenkins, Bryan Donnelly, Phylicia Dupree, Holly M. Poling, Inna N. Lobeck, Ruchi Bansal, Ana Ortiz-Perez, Sujit K. Mohanty, Jorge A. Bezerra, Monica M. McNeal, Haley Temple, Sarah Mowery
Publikováno v:
Hepatology, 74(2), 864-878. Wiley
Background and Aims: Biliary atresia (BA) is a devastating cholangiopathy of infancy. Upon diagnosis, surgical reconstruction by Kasai hepatoportoenterostomy (HPE) restores biliary drainage in a subset of patients, but most patients develop fibrosis
Autor:
Anna L. Peters, Seung Kim, Reena Mourya, Akihiro Asai, Amy Taylor, Michael Rogers, Kathleen Campbell, Lin Fei, Alexander Miethke, William F. Balistreri, Jorge A. Bezerra
Publikováno v:
The Journal of Pediatrics. :113439
Autor:
Julie Osborn, Reena Mourya, Unmesha Thanekar, Weizhe Su, Lin Fei, Pranavkumar Shivakumar, Jorge A. Bezerra
Publikováno v:
Hepatology communications. 6(5)
Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large-scale proteomics.