Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Reena, Zutshi"'
Autor:
Kareem A. Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael E. Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed A. Helal, Emily R. Derbyshire, Reena Zutshi, David H. Drewry
Publikováno v:
Journal of Medicinal Chemistry. 65:13172-13197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9157dae09bb16f8beecc10edc94755ec
https://doi.org/10.1021/acs.jmedchem.2c00996
https://doi.org/10.1021/acs.jmedchem.2c00996
Autor:
Deanna Tiek, Carrow I. Wells, Martin Schröder, Xiao Song, Carla Alamillo-Ferrer, Anshika Goenka, Rebeca Iglesia, Minghui Lu, Bo Hu, Frank Kwarcinski, Parvathi Sintha, Chandi de Silva, Mohammad Anwar Hossain, Alfredo Picado, William Zuercher, Reena Zutshi, Stefan Knapp, Rebecca B. Riggins, Shi-Yuan Cheng, David H. Drewry
Small molecule modulators are important tools to study both basic biology and the complex signaling of protein kinases. The cdc2-like kinases (CLK) are a family of four kinases that have garnered recent interest for their involvement in a diverse set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cef8fa600be194d2a92cfceacd2a70c
https://doi.org/10.1101/2022.12.15.520623
https://doi.org/10.1101/2022.12.15.520623
Autor:
Kareem Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy Havener, Michael Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed Helal, Emily Derbyshire, Reena Zutshi, David Drewry
The plasmodial kinases PfGSK3 and PfPK6 have been identified as essential for the asexual life stage of Plasmodium falciparum, and thus are considered viable novel drug targets to combat rising resistance to traditional antimalarial drugs. We recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77a07b433f8e6d1e238e150bf4065768
https://doi.org/10.26434/chemrxiv-2022-fpv0g
https://doi.org/10.26434/chemrxiv-2022-fpv0g
Autor:
Christopher R. M. Asquith, Louisa Temme, Michael P. East, Tuomo Laitinen, Julie Pickett, Frank E. Kwarcinski, Parvathi Sinha, Carrow I. Wells, Gary L. Johnson, Reena Zutshi, David H. Drewry
Publikováno v:
ChemMedChem
Deep annotation of a library of 4-anilinoquinolines led to the identification of 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 16 as a potent inhibitor (IC(50) = 14 nM) of Protein Kinase Novel 3 (PKN3) with micromolar activity in cells. Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726b88b789476418a97cda78a2b22181
https://pubmed.ncbi.nlm.nih.gov/35403825
https://pubmed.ncbi.nlm.nih.gov/35403825
Autor:
Apirat Chaikuad, Alfredo Picado, Shubin Liu, Stefan Knapp, Frank E Kwarcinski, Reena Zutshi, Parvathi Sinha, David H. Drewry, Safal Shrestha, Carrow I. Wells, Chandi S de Silva, Julie E. Pickett, William J. Zuercher, Natarajan Kannan, Timothy M. Willson
Publikováno v:
Journal of medicinal chemistry 63(23), 14626-14646 (2020). doi:10.1021/acs.jmedchem.0c01174
J Med Chem
J Med Chem
Journal of medicinal chemistry 63(23), 14626 - 14646 (2020). doi:10.1021/acs.jmedchem.0c01174
STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the r
STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c848f02a1d2a5cb888f5579bfc7d4
https://bib-pubdb1.desy.de/record/454003
https://bib-pubdb1.desy.de/record/454003
Autor:
Paul A. Dayton, Shukui Zhao, Susannah H. Bloch, Pat Schumann, Kim Penrose, Terry O. Matsunaga, Reena Zutshi, Alexander Doinikov, Katherine W. Ferrara
Publikováno v:
Molecular Imaging, Vol 5 (2006)
Lipid-coated perfluorocarbon nanodroplets are submicrometer-diameter liquid-filled droplets with proposed applications in molecularly targeted therapeutics and ultrasound (US) imaging. Ultrasonic molecular imaging is unique in that the optimal applic
Externí odkaz:
https://doaj.org/article/0d0e0ad6762647a3bbc411654198062b
Autor:
Paul A. Dayton, David Pearson, Jarrod Clark, Scott Simon, Patricia A. Schumann, Reena Zutshi, Terry O. Matsunaga, Katherine W. Ferrara
Publikováno v:
Molecular Imaging, Vol 3 (2004)
The goal of targeted ultrasound contrast agents is to significantly and selectively enhance the detection of a targeted vascular site. In this manuscript, three distinct contrast agents targeted to the α v β 3 integrin are examined. The α v β 3 i
Externí odkaz:
https://doaj.org/article/14489abcc6bb4f468203d5e22c5f537a
Autor:
Tuanny L Almeida, Timothy M. Willson, Álvaro Lorente-Macías, William J. Zuercher, Reena Zutshi, David H. Drewry, Jonathan M. Elkins, Carrow I. Wells, Cunyu Zhang, Julie E. Pickett, Juanita C. Limas, Opher Gileadi, Alexander Riemen, Alison D. Axtman, Jeanette Gowen Cook, Roberta R. Ruela-de-Sousa, Nirav Kapadia, Rafael M. Couñago
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective for AAK1/BMP2K over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa822ab7d835da8fb429a09d3cd1f937
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Rafael M. Couñago, A Riemen, William J. Zuercher, David H. Drewry, Álvaro Lorente-Macías, Juanita C. Limas, Jonathan M. Elkins, Roberta R. Ruela-de-Sousa, Alison D. Axtman, Nirav Kapadia, Reena Zutshi, Cook Jg, Carrow I. Wells, Opher Gileadi, T Almeida, Julie E. Pickett, C. Zhang, Timothy M. Willson
Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization of this 3-acylaminoindazole scaffold furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c4acd9800821eb7de6feaa56b828d6
https://doi.org/10.26434/chemrxiv.9756785.v1
https://doi.org/10.26434/chemrxiv.9756785.v1
Autor:
Thomas R. Porter, Rachel Labell, Reena Zutshi, William C. Culp, Evan C. Unger, Terry O. Matsunaga
Publikováno v:
Advanced Drug Delivery Reviews. 56:1291-1314
Lipid-coated microbubbles represent a new class of agents with both diagnostic and therapeutic applications. Microbubbles have low density. Stabilization of microbubbles by lipid coatings creates low-density particles with unusual properties for diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba12208488772b71222ca68ef8c4587
https://doi.org/10.1016/j.addr.2003.12.006
https://doi.org/10.1016/j.addr.2003.12.006