Výsledky vyhledávání - "Reema Thalji"

Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening

Publikováno v: Journal of medicinal chemistry. 65(21)

E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved in many cellular processes by acting as coactivators of a large number of transcription fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646b8bd1f0dea4957b345cc77c8b3999
https://pubmed.ncbi.nlm.nih.gov/36302181

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Publikováno v: Journal of Medicinal Chemistry. 50:4162-4176

A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2d5edd2a4e5f39a0ccaa4fa98a6e1e
https://doi.org/10.1021/jm070105d

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Akademický článek

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzob,e1,4diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors.

Publikováno v: Journal of Medicinal Chemistry; Aug2007, Vol. 50 Issue 17, p4162-4176, 15p

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