Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Reem Jada"'
Autor:
Reem Jada, Liron Zag, Veronika Borisov, Nina S. Levy, Shai Netser, Renad Jabarin, Shlomo Wagner, Kinneret Schragenheim-Rozales, Reut Shalgi, Andrew P. Levy
Publikováno v:
International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1495-1501 (2021)
Objectives Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human IQSEC2 missense mutation (A350V) for which we have created a corresponding A350V I
Externí odkaz:
https://doaj.org/article/84ce4ee8e3184e6091fc234735250169
Autor:
Eli J. Rogers, Reem Jada, Kinneret Schragenheim-Rozales, Megha Sah, Marisol Cortes, Matthew Florence, Nina S. Levy, Rachel Moss, Randall S. Walikonis, Raz Palty, Reut Shalgi, Daniela Lichtman, Alexandra Kavushansky, Nashaat Z. Gerges, Itamar Kahn, George K. E. Umanah, Andrew P. Levy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention. We
Externí odkaz:
https://doaj.org/article/14ef286995ec4aa7b07fafd45f233f65
Autor:
Kinneret Schragenheim-Rozales, Nina S. Levy, Shai Netser, Reut Shalgi, Renad Jabarin, Reem Jada, Veronika Borisov, Liron Zag, Shlomo Wagner, Andrew P. Levy
Publikováno v:
International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1495-1501 (2021)
Objectives Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human IQSEC2 missense mutation (A350V) for which we have created a corresponding A350V I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1228969568a93bd92189ec01e9bb1f5
https://doi.org/10.1080/02656736.2021.1988730
https://doi.org/10.1080/02656736.2021.1988730
Autor:
Owen Kane, Almedia McCoy, Reem Jada, Veronika Borisov, Liron Zag, Amir Zag, Kinneret Schragenheim-Rozales, Reut Shalgi, Nina S. Levy, Andrew P. Levy, Eric D. Marsh
Publikováno v:
Epilepsy research. 182
IQSEC2 is an X-linked gene localized to the post synaptic density encoding a GTP exchange factor that regulates NMDA mediated changes in synaptic function. Mutations in the IQSEC2 gene are associated with drug resistant epilepsy, intellectual disabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388fdf6c3a9d56b556986a6386cdb10c
https://pubmed.ncbi.nlm.nih.gov/35344748
https://pubmed.ncbi.nlm.nih.gov/35344748
Autor:
Liron Mizrahi, Ayat Asleh, Boris Brant, Andrew P. Levy, Reem Jada, George K.E. Umanah, Tchelet Stern, Nina S. Levy, Shani Stern, Idan Rosh, Huda Adwan Shekhidem, Yam Stern, Polina Ofer
Publikováno v:
Molecular psychiatry. 26(12)
Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual disability (ID). We used induced pluripotent stem cell (iPSC) technology to obtain hippocampal neurons to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256016cd8f82b5db949b43615541c727
https://pubmed.ncbi.nlm.nih.gov/34535765
https://pubmed.ncbi.nlm.nih.gov/34535765
Publikováno v:
Neurobiology of Learning and Memory. 154:5-11
Metaplasticity is the dynamic regulation of the ability to induce activity-dependent synaptic plasticity and is governed by the prior history of the synapses. Previous reports by others and us have shown that behavioral stress induces a form of emoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedd30efb65244c2b571e940845b3e90
https://doi.org/10.1016/j.nlm.2018.02.011
https://doi.org/10.1016/j.nlm.2018.02.011
Autor:
Nashaat Z. Gerges, Reem Jada, Reut Shalgi, Megha Sah, Eli Rogers, Daniela Lichtman, Rachel E. Moss, Matthew A. Florence, George K.E. Umanah, Marisol Cortes, Nina S. Levy, Itamar Kahn, Alexandra Kavushansky, Randall S. Walikonis, Raz Palty, Kinneret Schragenheim-Rozales, Andrew P. Levy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d65d0d22f1ef8080c99a6e373c0e2
https://doi.org/10.3389/fnmol.2019.00043
https://doi.org/10.3389/fnmol.2019.00043
Publikováno v:
Neurobiology of learning and memory. 154
Metaplasticity is the dynamic regulation of the ability to induce activity-dependent synaptic plasticity and is governed by the prior history of the synapses. Previous reports by others and us have shown that behavioral stress induces a form of emoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fb91c9c9d7d20ecabb71727c388dddf
https://pubmed.ncbi.nlm.nih.gov/29438741
https://pubmed.ncbi.nlm.nih.gov/29438741
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3038 (2019)
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3038 (2019)
Mutations in IQSEC2 cause intellectual disability (ID), which is often accompanied by seizures and autism. A number of studies have shown that IQSEC2 is an abundant protein in excitatory synapses and plays an important role in neuronal development as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1a83596b8852757af4b1313119854e
https://doi.org/10.3390/ijms20123038
https://doi.org/10.3390/ijms20123038