Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Reem H Elbekai"'
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92832 (2014)
In preparation for testing the safety of using serotype 2 recombinant adeno-associated vector, encoding Aquaporin-1 to treat radiation-induced salivary gland damage in a phase 1 clinical trial, we conducted a 13 week GLP biodistribution and toxicolog
Externí odkaz:
https://doaj.org/article/570388e5bbaa40e0a7342973957c7332
Autor:
Melissa D. Denton, Tom J. Vidmar, Reem H. Elbekai, John Martineck, Caren Brown, Peter C. Mann, Madhav G. Paranjpe, Marie McKeon
Publikováno v:
International Journal of Toxicology. 40:311-321
Our experience indicates that extrapolation of doses from the maximum tolerated doses (MTD) derived from 4-week dose range finding (DRF) studies conducted in CByB6F1 may overpredict tolerability and undermine utility of the high-dose groups in 26-wee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a023730946e0a30310f8e23c370687a
https://doi.org/10.1177/10915818211003302
https://doi.org/10.1177/10915818211003302
Autor:
Caren Brown, Peter C. Mann, Marie McKeon, Madhav G. Paranjpe, Jessica L. Belich, Dayauna R. Richardson, Reem H. Elbekai, Tom J. Vidmar
Publikováno v:
International Journal of Toxicology. 36:21-28
Three levels of nasal cavity sections (anterior, middle, and most posterior) are routinely examined as protocol required tissues in our 26-week carcinogenicity studies involving Tg.rasH2 mice. Exudative inflammation of the nasal cavity was noted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::660285895e2468c4177aea58aa4d0865
https://doi.org/10.1177/1091581816673583
https://doi.org/10.1177/1091581816673583
Autor:
Marie McKeon, Tom J. Vidmar, Madhav G. Paranjpe, Reem H. Elbekai, Dayauna R. Richardson, Peter C. Mann, Jessica L. Belich
Publikováno v:
International Journal of Toxicology. 36:29-34
Tg.rasH2 mice are predisposed to hemangiosarcomas. Following the spleen, the uterus is the second most commonly affected organ in the female mice. Female mice are also predisposed to spontaneous vascular proliferative lesions on the serosal surface o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c99786d0bb1a66c27fa835920b827b7
https://doi.org/10.1177/1091581816659068
https://doi.org/10.1177/1091581816659068
Autor:
Reem H. Elbekai, Caren Brown, Marie McKeon, Madhav G. Paranjpe, Jessica L. Belich, Daniel J. Patrick, Peter C. Mann
Publikováno v:
Toxicologic pathology. 47(1)
This article presents the historical control data of spontaneous tumors in Tg.rasH2 published in 2013 (2004–2012) and compares and contrasts it to more recent data collected from 2013 to 2018, reporting differences in the average percentage inciden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e725ef59e1feb5c85917be4e8c20a8
https://pubmed.ncbi.nlm.nih.gov/30407148
https://pubmed.ncbi.nlm.nih.gov/30407148
Autor:
Reem H. Elbekai, Robert R. Young, Annette C. Rohr, Harshini Dinesdurage, Deborah M. Proctor, Mina Suh, Mark A. Harris, Chad M. Thompson
Publikováno v:
Environmental and Molecular Mutagenesis. 56:621-628
Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e8035358e3da4663960c6bebc11dfaa
https://doi.org/10.1002/em.21952
https://doi.org/10.1002/em.21952
Autor:
Robert R. Young, Annette C. Rohr, Reem H. Elbekai, Mina Suh, Deborah M. Proctor, Harshini Dinesdurage, Chad M. Thompson
Publikováno v:
Environmental and Molecular Mutagenesis. 56:629-636
The Big Blue® (BB) in vivo mutation assay uses transgenic rodents to measure treatment-induced mutations in virtually any tissue. The BB assay can be conducted in rats or mice and is ideal for investigating tissue-specific mutagenic mode of action o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85af2e4e2bc5b5eba49278b479647e5f
https://doi.org/10.1002/em.21951
https://doi.org/10.1002/em.21951
Autor:
Marie E. McKeon, Reem H. Elbekai, Gordon C. Hard, John C. Seely, Jessica L. Belich, Madhav G. Paranjpe, Peter C. Mann
Publikováno v:
Toxicologic Pathology. 44:633-635
We report renal tubular adenomas and a carcinoma in 26-week Tg.rasH2 mouse carcinogenicity studies, which have not been reported to date either at our facility or in other published data. However, during the year 2014, renal tubular tumors were prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bf74c4633e3791dfec20869ab6fb69
https://doi.org/10.1177/0192623315627216
https://doi.org/10.1177/0192623315627216
Autor:
Tom J. Vidmar, Reem H. Elbekai, Marie McKeon, Madhav G. Paranjpe, Jessica L. Belich, Caren Brown
Publikováno v:
International journal of toxicology. 36(4)
Our recent retrospective analysis of data, collected from 29 Tg.rasH2 mouse carcinogenicity studies, determined how successful the strategy of choosing the high dose for the 26-week studies was based on the estimated maximum tolerated dose (EMTD) der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45df7269a0ec2a23b7f9aa2b7a84605d
https://pubmed.ncbi.nlm.nih.gov/28553733
https://pubmed.ncbi.nlm.nih.gov/28553733
Publikováno v:
Toxicologic Pathology. 43:611-620
High doses in Tg.rasH2 carcinogenicity studies are usually set at the maximum tolerated dose (MTD), although this dose selection strategy has not been critically evaluated. We analyzed the body weight gains (BWGs), mortality, and tumor response in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008a037fc0e07edd62a066276819ba6e
https://doi.org/10.1177/0192623314557526
https://doi.org/10.1177/0192623314557526