Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

Autor: Reeder, SM, Reuschel, EL, Bah, MA, Yun, K, Tursi, NJ, Kim, KY, Chu, J, Zaidi, FI, Yilmaz, I, Hart, RJ, Perrin, B, Xu, Z, Humeau, L, Weiner, DB, Aly, Ahmed Sayed Ibrahım

The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::416cba6bac853bd1cfadfe61c2af1b5e
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13486

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model.

Autor: Tursi NJ; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Reeder SM; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Flores-Garcia Y; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Bah MA; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Mathis-Torres S; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Salgado-Jimenez B; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Esquivel R; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Xu Z; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Chu JD; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Humeau L; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Zavala F; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA. dweiner@wistar.org.

Publikováno v: Scientific reports [Sci Rep] 2022 Aug 22; Vol. 12 (1), pp. 14313. Date of Electronic Publication: 2022 Aug 22.

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.

Autor: Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Walters JN; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Reuschel EL; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Schultheis K; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Parzych E; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Gary EN; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Maricic I; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Purwar M; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Eblimit Z; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Walker SN; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Guimet D; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Bhojnagarwala P; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Adeniji OS; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Doan A; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Xu Z; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Elwood D; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Reeder SM; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Pessaint L; Bioqual, Rockville, MD 20852, USA., Kim KY; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Cook A; Bioqual, Rockville, MD 20852, USA., Chokkalingam N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Finneyfrock B; Bioqual, Rockville, MD 20852, USA., Tello-Ruiz E; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Dodson A; Bioqual, Rockville, MD 20852, USA., Choi J; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Generotti A; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Harrison J; Bioqual, Rockville, MD 20852, USA., Tursi NJ; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Andrade VM; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Dia Y; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Zaidi FI; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Andersen H; Bioqual, Rockville, MD 20852, USA., Abdel-Mohsen M; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Lewis MG; Bioqual, Rockville, MD 20852, USA., Muthumani K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kim JJ; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Kulp DW; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Humeau LM; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Ramos SJ; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Broderick KE; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2021 Oct 19; Vol. 2 (10), pp. 100420. Date of Electronic Publication: 2021 Sep 28.

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.

Autor: Reeder SM; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Reuschel EL; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Bah MA; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Yun K; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tursi NJ; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Kim KY; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Chu J; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Zaidi FI; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Yilmaz I; Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey., Hart RJ; Department of Tropical Medicine, Tulane University, New Orleans, LA 70112, USA., Perrin B; Department of Tropical Medicine, Tulane University, New Orleans, LA 70112, USA., Xu Z; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Humeau L; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA 19462, USA., Weiner DB; The Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA., Aly ASI; Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey.; Department of Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2020 Jan 10; Vol. 8 (1). Date of Electronic Publication: 2020 Jan 10.

Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.

Autor: Rausch K; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Hackett BA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Weinbren NL; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Reeder SM; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Sadovsky Y; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 19104, USA; Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 19104, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 19104, USA., Hunter CA; Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Schultz DC; High-Throughput Screening Core, University of Pennsylvania, Philadelphia, PA 19104, USA., Coyne CB; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 19104, USA; Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 19104, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 19104, USA., Cherry S; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cherrys@mail.med.upenn.edu.

Publikováno v: Cell reports [Cell Rep] 2017 Jan 17; Vol. 18 (3), pp. 804-815.