Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies.

Autor: Casali BT; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA; Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN 46202, USA. Electronic address: btc8@case.edu., MacPherson KP; Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN 46202, USA. Electronic address: kpmartin@indiana.edu., Reed-Geaghan EG; College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address: ereedgeaghan@neomed.edu., Landreth GE; Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN 46202, USA. Electronic address: glandret@iu.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2020 Aug; Vol. 142, pp. 104956. Date of Electronic Publication: 2020 May 30.

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

Autor: Cheng-Hathaway PJ; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.; Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Reed-Geaghan EG; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA., Jay TR; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA., Casali BT; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.; Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Bemiller SM; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Puntambekar SS; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., von Saucken VE; Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Williams RY; Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Karlo JC; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA., Moutinho M; Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Xu G; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA., Ransohoff RM; Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA.; Third Rock Ventures, Boston, MA, 02116, USA., Lamb BT; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.; Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA., Landreth GE; Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. glandret@iu.edu.; Department of Anatomy and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA. glandret@iu.edu.; Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA. glandret@iu.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2018 Jun 01; Vol. 13 (1), pp. 29. Date of Electronic Publication: 2018 Jun 01.

Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.

Autor: Reed-Geaghan EG; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106., Wright MC; Center for Neurosciences, and., See LA; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106., Adelman PC; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and., Lee KH; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and., Koerber HR; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and., Maricich SM; Department of Pediatrics, Richard King Mellon Institute for Pediatric Research, University of Pittsburgh and Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224 stephen.maricich@chp.edu.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2016 Apr 13; Vol. 36 (15), pp. 4362-76.

Peripheral somatosensation: a touch of genetics.

Autor: Reed-Geaghan EG; Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, United States., Maricich SM

Publikováno v: Current opinion in genetics & development [Curr Opin Genet Dev] 2011 Jun; Vol. 21 (3), pp. 240-8. Date of Electronic Publication: 2011 Jan 27.

CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

Autor: Reed-Geaghan EG; Department of Neurosciences, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, USA., Savage JC, Hise AG, Landreth GE

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2009 Sep 23; Vol. 29 (38), pp. 11982-92.