Behavioral and brain mechanisms mediating conditioned flight behavior in rats

Autor: Michael S. Totty, Naomi Warren, Isabella Huddleston, Karthik R. Ramanathan, Reed L. Ressler, Cecily R. Oleksiak, Stephen Maren

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Environmental contexts can inform animals of potential threats, though it is currently unknown how context biases the selection of defensive behavior. Here we investigated context-dependent flight responses with a Pavlovian serial-compound s

Externí odkaz: https://doaj.org/article/6144c436f3634dfebf54850fad3c3297

Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear

Autor: Stephen Maren, Reed L. Ressler, Thomas F. Giustino, Paul J. Fitzgerald

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Fear relapse represents a significant problem for individuals suffering from stress- and trauma-related disorders such as posttraumatic stress disorder. Here, we show that locus coeruleus norepinephrine activation produces fear relapse i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cebe5d98a575bc92a02f5f577b36e97
http://europepmc.org/articles/PMC6486780

Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum

Autor: Elizabeth Souter, Davide Dulcis, Thomas S. Hnasko, Vivien Zell, Ji Hoon Yoo, Adam McPherson, Navarre Gutierrez-Reed, Reed L. Ressler, Lauren Faget

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature communications, vol 9, iss 1
Faget, L; Zell, V; Souter, E; McPherson, A; Ressler, R; Gutierrez-Reed, N; et al.(2018). Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum. NATURE COMMUNICATIONS, 9, 849. doi: 10.1038/s41467-018-03125-y. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2nv9f9c5
Nature Communications

The ventral pallidum (VP) lies at the interface between sensory, motor, and cognitive processing—with a particular role in mounting behavioral responses to rewards. Though the VP is predominantly GABAergic, glutamate neurons were recently identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b58ea59991f4162a660c33989b66d89
https://doaj.org/article/0d8105c30e874e1aa7d317c939b86bc1

NMDA receptors in the CeA and BNST differentially regulate fear conditioning to predictable and unpredictable threats

Autor: Travis D. Goode, Carolyn Evemy, Reed L. Ressler, Stephen Maren

Publikováno v: Neurobiol Learn Mem

Considerable work demonstrates that Pavlovian fear conditioning depends on N-methyl-D-aspartate (NMDA) receptor-dependent plasticity within the amygdala. In addition, the bed nucleus of the stria terminalis (BNST) has also been implicated in fear con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c8d78eee6e119c289d4c467e2375fd
https://doi.org/10.1016/j.nlm.2020.107281

Nucleus Reuniens Is Required for Encoding and Retrieving Precise, Hippocampal-Dependent Contextual Fear Memories in Rats

Autor: Jingji Jin, Karthik R. Ramanathan, Reed L. Ressler, Stephen Maren

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(46)

The nucleus reuniens (RE) is a ventral midline thalamic nucleus that interconnects the medial prefrontal cortex (mPFC) and hippocampus (HPC). Considerable data indicate that HPC-mPFC circuits are involved in contextual and spatial memory; however, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3209069ecf52fb08fa1c95580386bec0
https://pubmed.ncbi.nlm.nih.gov/30282726