Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Reed E.S. Harrison"'
Autor:
Reed E.S. Harrison, Tse-Shun Huang, Yiyan Yu, Jin Zhang, Shaoying Lu, Sheng Zhong, Yan Huang, Xianhui Meng, Shu Chien, Krit Charupanit, Yiwen Shi, Jie Sun, Praopim Limsakul, Longwei Liu, Yingxiao Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
The limited sensitivity of Förster Resonance Energy Transfer (FRET) biosensors hinders their broader applications. Here, we develop an approach integrating high-throughput FRET sorting and next-generation sequencing (FRET-Seq) to identify sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7d3f9c760c0bfdaf177602c44c1912
https://doaj.org/article/bb6ff210871349e99294dd89352b8506
https://doaj.org/article/bb6ff210871349e99294dd89352b8506
Autor:
Reed E.S. Harrison, Krit Charupanit, Xianhui Meng, Yiwen Shi, Longwei Liu, Yingxiao Wang, Tse-Shun Huang, Yiyan Yu, Praopim Limsakul, Sheng Zhong, Shu Chien, Jin Zhang, Jie Sun, Yan Huang, Shaoying Lu
Genetically-encoded biosensors based on FRET have been widely used to dynamically monitor the activity of protein tyrosine kinases (PTKs) in living cell with high spatiotemporal resolution. However, the limitation in sensitivity, specificity, and dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99f3f7f8e87256cbc488aea1da13e81e
https://doi.org/10.21203/rs.3.pex-1580/v1
https://doi.org/10.21203/rs.3.pex-1580/v1
Autor:
Dimitrios Morikis, Reed E.S. Harrison
Publikováno v:
Biophysical Journal. 116:215-226
A single nucleotide polymorphism, tyrosine at position 402 to histidine (Y402H), within the gene encoding complement factor H (FH) predisposes individuals to acquiring age-related macular degeneration (AMD) after aging. This polymorphism occurs in sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a9846d6b1d117c9ba5915d1b0a60d4
https://doi.org/10.1016/j.bpj.2018.12.007
https://doi.org/10.1016/j.bpj.2018.12.007
Autor:
Clément N. David, Monica J. Carson, J. Philip Nance, Tyler A. Landrith, Emma H. Wilson, Kathryn E. McGovern, Shahani Noor, Andre Obenaus, Dimitrios Morikis, Danielle Worth, Reed E.S. Harrison
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Central nervous system (CNS) injury and infection can result in profound tissue remodeling in the brain, the mechanism and purpose of which is poorly understood. Infection with the protozoan parasite Toxoplasma gondii causes chronic infection and inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a957924866a78b906782fad6aad0629
http://europepmc.org/articles/PMC7907143
http://europepmc.org/articles/PMC7907143
Autor:
Rohaine V. Hsu, Nehemiah T. Zewde, Valentine I. Vullev, Reed E.S. Harrison, Yogesh B. Narkhede, Giulia Palermo, Dimitrios Morikis
Publikováno v:
ACS Med Chem Lett
ACS medicinal chemistry letters, vol 11, iss 5
ACS medicinal chemistry letters, vol 11, iss 5
[Image: see text] C3d is a hallmark protein of the complement system, whose presence is critical to measure the progression of several immune diseases. Here, we propose to directly target C3d through small peptides mimicking the binding of its natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ab9d73691b74e6172accb9e4e2e861
https://europepmc.org/articles/PMC7236534/
https://europepmc.org/articles/PMC7236534/
Autor:
Phanourios Tamamis, Ronald D. Gorham, Dimitrios Morikis, Alexis V. Coley, Rohith R. Mohan, Chris A. Kieslich, Reed E.S. Harrison, Mark Wilson, Vasilios A. Morikis, Asuka A. Orr
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 6, Pp 6427-6438 (2018)
ACS Omega, Vol 3, Iss 6, Pp 6427-6438 (2018)
The complement system is our first line of defense against foreign pathogens, but when it is not properly regulated, complement is implicated in the pathology of several autoimmune and inflammatory disorders. Compstatin is a peptidic complement inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a934b4aa3aa48fe883b87210b320ef1
http://europepmc.org/articles/PMC6130793
http://europepmc.org/articles/PMC6130793
Autor:
Martín Alcorlo, Oscar Llorca, Andrés López-Perrote, Marta Subias, Dimitrios Morikis, Reed E.S. Harrison, Santiago Rodríguez de Córdoba
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
C3b, the central component of the alternative pathway (AP) of the complement system, coexists as a mixture of conformations in solution. These conformational changes can affect interactions with other proteins and complement regulators. Here we combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0372367cabc52aba4de21f72244551d9
https://doi.org/10.1016/j.molimm.2016.12.015
https://doi.org/10.1016/j.molimm.2016.12.015
Autor:
Jenny Wu, Binbin Cheng, Liling Tang, Rongxue Wan, Yiqian Wu, Shaoying Lu, Yingxiao Wang, Reed E.S. Harrison, Cheng Zhu, Kaitao Li, Jiaming Wei, Qin Peng, Mingxing Ouyang, Lei Lei
Publikováno v:
Science Advances
A new biosensor was engineered to visualize Lck kinase preactivation and regulation in live T cells.
Lck plays crucial roles in TCR signaling. We developed a new and sensitive FRET biosensor (ZapLck) to visualize Lck kinase activity with high sp
Lck plays crucial roles in TCR signaling. We developed a new and sensitive FRET biosensor (ZapLck) to visualize Lck kinase activity with high sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8978e731834de8b4280992e055581ecf
https://doi.org/10.1126/sciadv.aau2001
https://doi.org/10.1126/sciadv.aau2001
Autor:
James W. Murphy, Jen-Shin Song, Kak-Shan Shia, Chien-Huang Wu, Kathryn E. Luker, Reed E.S. Harrison, Chuan-Jen Wang, Dimitrios Morikis, Elias Lolis, Natalie A. Drucker, Brock Humphries, Yung-Chi Cheng, Gary D. Luker, Lun K. Tsou, Eric M. Rosenberg, Deepa Rajasekaran
Publikováno v:
Cell Chem Biol
The G protein-coupled receptor (GPCR) CXCR4 is a co-receptor for HIV and is involved in cancers and autoimmune diseases. We characterized five purine or quinazoline core polyamine pharmacophores used for targeting CXCR4 dysregulation in diseases. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc893131622e0aff6a7a1f2eabcb575a
https://europepmc.org/articles/PMC6736600/
https://europepmc.org/articles/PMC6736600/
Publikováno v:
Curr Opin Solid State Mater Sci
Liquid-liquid phase separation is increasingly recognized as a phenomenon that affects cell behavior. For example, phase separation of transcription factors and coactivators has been shown to drive efficient transcription. For many years, phase separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920dcf162f0750058adc7587d26a3f4d
https://doi.org/10.1016/j.cossms.2020.100892
https://doi.org/10.1016/j.cossms.2020.100892