Mechanism and in vivo activity of a small activating RNA targeting CEBPA, a novel therapeutic in clinical trials for liver disease

Autor: Voutila, J, Reebye, V, Roberts, T, Blakey, D, Habib, R, Mallappa, O, Anjaneyulu, M, Jayaprakash, A, Huber, H, Saetrom, P, Rossi, J, Habib, N

Publikováno v: 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::1b39d3245e4e32be44182a83e45c46ad
http://hdl.handle.net/10044/1/48854

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RNA Activation

Autor: Zhao, X, Voutila, J, Habib, N, Reebye, V

Publikováno v: Innovative Medicine ISBN: 9784431556503

The ability to manipulate gene expression is invaluable for understanding the molecular pathogenesis of disease as well as for developing novel therapeutics. RNA interference provides a robust platform for the knockdown of a specific gene at the post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05fdf29e7d68ef146921629646543b9
https://doi.org/10.1007/978-4-431-55651-0_20

A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo

Autor: Reebye, V., Sætrom, P., Mintz, P.J., Wen Huang, K., Lin, V., Swiderski, P., Peng, Ling, Liu, T., Xiaoxuan, L., Jensen, S., Zacharoulis, D., Kostomitsopoulos, N., Kasahara, N., Nicholls, J., Jiao, LR., Pai, M., Haoudi, A., Tomalia, D.A., Rossi, J.J., Habib, N.A.

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2014, 59 (1), pp.216-227. ⟨10.1002/hep.26669⟩
Hepatology, 2014, 59 (1), pp.216-227. ⟨10.1002/hep.26669⟩

Hepatocellular carcinoma (HCC) occurs predominantly in patients with liver cirrhosis. Here we show an innovative RNA-based targeted approach to enhance endogenous albumin production while reducing liver tumor burden. We designed short-activating RNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d43bca859e9672a64b2afb2a7659d922
https://hal.archives-ouvertes.fr/hal-00975037

Functional synergy of CCAAT/enhancer-binding protein alpha and beta promotes anti-proliferative effect in HCC

Autor: Zhao, X., Reebye, V., Habib, N.

Publikováno v: In HPB September 2018 20 Supplement 2:S378-S378