Výsledky vyhledávání - "Redmond P. Smyth"

Akademický článek

Sequencing accuracy and systematic errors of nanopore direct RNA sequencing

Autor: Wang Liu-Wei, Wiep van der Toorn, Patrick Bohn, Martin Hölzer, Redmond P. Smyth, Max von Kleist

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)

Abstract Background Direct RNA sequencing (dRNA-seq) on the Oxford Nanopore Technologies (ONT) platforms can produce reads covering up to full-length gene transcripts, while containing decipherable information about RNA base modifications and poly-A

Externí odkaz: https://doaj.org/article/cd3c7d0cec67474b96de101bc58c8145

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Akademický článek

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Autor: Matthias M. Zimmer, Anuja Kibe, Ulfert Rand, Lukas Pekarek, Liqing Ye, Stefan Buck, Redmond P. Smyth, Luka Cicin-Sain, Neva Caliskan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Programmed ribosomal frameshifting (PRF) occurs in many viruses including SARS-CoV-2 to allow the translation of multiple proteins from a single transcript. Here, the authors identify the human short isoform of the zinc-finger antiviral protein (ZAP-

Externí odkaz: https://doaj.org/article/809ea65c717f4479a1a148943d4d206c

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Akademický článek

RNA Structures and Their Role in Selective Genome Packaging

Autor: Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth

Publikováno v: Viruses, Vol 13, Iss 9, p 1788 (2021)

To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in geno

Externí odkaz: https://doaj.org/article/f1f33ddbdbfd4ebb92b21552c10fa2a6

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Akademický článek

RNA Structure—A Neglected Puppet Master for the Evolution of Virus and Host Immunity

Autor: Redmond P. Smyth, Matteo Negroni, Andrew M. Lever, Johnson Mak, Julia C. Kenyon

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins. Recent advances

Externí odkaz: https://doaj.org/article/115814e119bc4acf81f27f9fbea66b42

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Akademický článek

Structural and Functional Motifs in Influenza Virus RNAs

Autor: Damien Ferhadian, Maud Contrant, Anne Printz-Schweigert, Redmond P. Smyth, Jean-Christophe Paillart, Roland Marquet

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Influenza A viruses (IAV) are responsible for recurrent influenza epidemics and occasional devastating pandemics in humans and animals. They belong to the Orthomyxoviridae family and their genome consists of eight (-) sense viral RNA (vRNA) segments

Externí odkaz: https://doaj.org/article/15ef7eb797f14524bc8641ede40c1132

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Akademický článek

The Life-Cycle of the HIV-1 Gag–RNA Complex

Autor: Elodie Mailler, Serena Bernacchi, Roland Marquet, Jean-Christophe Paillart, Valérie Vivet-Boudou, Redmond P. Smyth

Publikováno v: Viruses, Vol 8, Iss 9, p 248 (2016)

Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process

Externí odkaz: https://doaj.org/article/db9105464ceb47b0842e53b298e08ef9

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Akademický článek

HIV-1 Mutation and Recombination Rates Are Different in Macrophages and T-cells

Autor: Deborah Cromer, Timothy E. Schlub, Redmond P. Smyth, Andrew J. Grimm, Abha Chopra, Simon Mallal, Miles P. Davenport, Johnson Mak

Publikováno v: Viruses, Vol 8, Iss 4, p 118 (2016)

High rates of mutation and recombination help human immunodeficiency virus (HIV) to evade the immune system and develop resistance to antiretroviral therapy. Macrophages and T-cells are the natural target cells of HIV-1 infection. A consensus has not

Externí odkaz: https://doaj.org/article/d3c65b5342ff43cc951729aaffd74727

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