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Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice.

Autor: Pfitzer J; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA., Pinky PD; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA., Perman S; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA., Redmon E; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA., Cmelak L; Department of Psychological Sciences, Auburn University, Auburn, Alabama, USA., Suppiramaniam V; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA.; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.; Department of Molecular and Cellular Biology, College of Science and Mathematics, Kennesaw State University, Kennesaw, Georgia, USA., Coric V; Biohaven Pharmaceuticals Inc., New Haven, Connecticut, USA., Qureshi IA; Biohaven Pharmaceuticals Inc., New Haven, Connecticut, USA., Gramlich MW; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.; Department of Physics, Auburn University, Auburn, Alabama, USA., Reed MN; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA.; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.

Publikováno v: Journal of neurochemistry [J Neurochem] 2025 Jan; Vol. 169 (1), pp. e16215. Date of Electronic Publication: 2024 Aug 30.