The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites.

Autor: Zung N; Department of Molecular Genetics, Weizmann Institute of Science, Israel., Aravindan N; Interfaculty Institute of Biochemistry, University of Tuebingen, Germany., Boshnakovska A; Department of Cellular Biochemistry, University Medical Center Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, Germany.; Max Planck Institute for Multidisciplinary Sciences, D-37077, Germany., Valenti R; Department of Molecular Genetics, Weizmann Institute of Science, Israel., Preminger N; Department of Molecular Genetics, Weizmann Institute of Science, Israel., Jonas F; Department of Molecular Genetics, Weizmann Institute of Science, Israel., Yaakov G; Department of Molecular Genetics, Weizmann Institute of Science, Israel., Willoughby MM; School of Chemistry and Biochemistry, Georgia Institute of Technology, USA.; Biochemistry and Molecular Biology Department, University of Nebraska Medical Center, USA., Homberg B; Department of Cellular Biochemistry, University Medical Center Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, Germany.; Max Planck Institute for Multidisciplinary Sciences, D-37077, Germany., Keller J; University Medical Center Göttingen, Institute for Neuropathology, 37077, Germany.; Collaborative Research Center 1190 'Compartmental Gates and Contact Sites in Cells', University of Göttingen, Germany., Kupervaser M; The De Botton Protein Profiling institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Israel., Dezorella N; Electron Microscopy Unit, Chemical Research Support, Weizmann Institute of Science, Israel., Dadosh T; Electron Microscopy Unit, Chemical Research Support, Weizmann Institute of Science, Israel., Wolf SG; Electron Microscopy Unit, Chemical Research Support, Weizmann Institute of Science, Israel., Itkin M; Life Sciences Core Facilities, Weizmann Institute of Science, Israel., Malitsky S; Life Sciences Core Facilities, Weizmann Institute of Science, Israel., Brandis A; Life Sciences Core Facilities, Weizmann Institute of Science, Israel., Barkai N; Department of Molecular Genetics, Weizmann Institute of Science, Israel., Fernández-Busnadiego R; University Medical Center Göttingen, Institute for Neuropathology, 37077, Germany.; Collaborative Research Center 1190 'Compartmental Gates and Contact Sites in Cells', University of Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37077, Germany.; Faculty of Physics, University of Göttingen, 37077, Germany., Reddi AR; School of Chemistry and Biochemistry, Georgia Institute of Technology, USA., Rehling P; Department of Cellular Biochemistry, University Medical Center Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, Germany.; Max Planck Institute for Multidisciplinary Sciences, D-37077, Germany., Rapaport D; Interfaculty Institute of Biochemistry, University of Tuebingen, Germany., Schuldiner M; Department of Molecular Genetics, Weizmann Institute of Science, Israel.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 12. Date of Electronic Publication: 2024 May 12.

Depletion assisted hemin affinity (DAsHA) proteomics reveals an expanded landscape of heme-binding proteins in the human proteome.

Autor: Kim H; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA., Moore CM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA., Mestre-Fos S; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA., Hanna DA; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA., Williams LD; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA., Reddi AR; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA., Torres MP; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Publikováno v: Metallomics : integrated biometal science [Metallomics] 2023 Mar 06; Vol. 15 (3).

Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis.

Autor: Donegan RK; School of Chemistry and Biochemistry, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.; Department of Chemistry, Barnard College, New York, New York, USA., Fu Y; School of Chemistry and Biochemistry, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA., Copeland J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Idga S; Department of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, New York, USA., Brown G; School of Chemistry and Biochemistry, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA., Hale OF; School of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA., Mitra A; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Yang H; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA., Dailey HA; Department of Microbiology, University of Georgiagrid.213876.9, Athens, Georgia, USA.; Department of Biochemistry and Molecular Biology, University of Georgiagrid.213876.9, Athens, Georgia, USA., Niederweis M; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Jain P; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.; Cell Therapy and Cell Engineering Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Reddi AR; School of Chemistry and Biochemistry, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.; School of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.; Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2022 Oct 26; Vol. 10 (5), pp. e0360422. Date of Electronic Publication: 2022 Sep 28.

Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells.

Autor: Hanna DA; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA., Moore CM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA., Liu L; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Yuan X; Department of Animal and Avian Sciences, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA., Dominic IM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA., Fleischhacker AS; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Hamza I; Department of Animal and Avian Sciences, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA., Ragsdale SW; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Reddi AR; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA; Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA. Electronic address: amit.reddi@chemistry.gatech.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Feb; Vol. 298 (2), pp. 101549. Date of Electronic Publication: 2021 Dec 29.

Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase.

Autor: Dietz JV; Department of Biochemistry, University of Nebraska, Lincoln, NE, 68588, USA., Willoughby MM; School of Chemistry and Biochemistry and School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA., Piel RB 3rd; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA., Ross TA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA., Bohovych I; Department of Biochemistry, University of Nebraska, Lincoln, NE, 68588, USA., Addis HG; Department of Chemistry and Biochemistry, College of Charleston, Charleston, SC, 29424, USA., Fox JL; Department of Chemistry and Biochemistry, College of Charleston, Charleston, SC, 29424, USA., Lanzilotta WN; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA., Dailey HA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA; Department of Microbiology, University of Georgia, Athens, GA, 30602, USA., Wohlschlegel JA; Department of Biological Chemistry, University of California, Los Angeles, CA, 90095, USA., Reddi AR; School of Chemistry and Biochemistry and School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA., Medlock AE; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA; Augusta University/University of Georgia Medical Partnership, Athens, GA, 30602, USA., Khalimonchuk O; Department of Biochemistry, University of Nebraska, Lincoln, NE, 68588, USA; Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE, 68588, USA; Fred & Pamela Buffett Cancer Center, Omaha, NE, 68198, USA. Electronic address: okhalimonchuk2@unl.edu.

Publikováno v: Redox biology [Redox Biol] 2021 Oct; Vol. 46, pp. 102125. Date of Electronic Publication: 2021 Sep 10.